Lecture 13 Flashcards

1
Q

What is a transudate?

A

non-inflammatory increase in interstitial fluid (ISF)

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2
Q

What is a modified transudate?

A

a transudate that is high in protein but low in cells

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3
Q

What is oedema?

A

non-inflammatory increase in ISF

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4
Q

What is an exudate?

A

inflammatory increase in ISF

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5
Q

What is an effusion?

A

exudate into a body cavity

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6
Q

What is the process that is involved in leukocyte extravasation?

A
  1. Selectins
  2. Integrins
  3. Adhesion molecules
  4. Transmigration
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7
Q

What are the cell involved in a bacterial cellular response?

A
  1. Neutrophils
  2. Macrophages
  3. Lymphocytes
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8
Q

What are the cells that are involved in a viral cellular response?

A
  1. T lymphocytes
  2. B lymphocytes
  3. NK cells
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9
Q

What are the cells that are involved in an allergic response?

A
  1. Mast cells
  2. Eosinophils
  3. Lymphocytes
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10
Q

What are the cells that are involved in a parasite response?

A
  1. Eosinophils
  2. Macrophages
  3. Lymphocytes
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11
Q

What are the main types of cells that secrete histamine?

A

Mast cells

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12
Q

What are the main types of cells that secrete prostaglandins and leukotrienes?

A

All leukocytes

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13
Q

What are the two systems that are directly activated by Factor XII (Hageman Factor)?

A

Kinin system (bradykinin) and the coagulation/fibrinolysis system

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14
Q

What are the main components involved in complement activation?

A

C3a, C5a, C3b, C5b

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15
Q

What are the main arachidonic acid metabolites and what secretes them?

A

Arachidonic acid metabolites = Thromboxane (TxA), Prostaglandins (PG), Leukotrienes (LT), Lipoxins, Resolvins

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16
Q

What are the do the vasoactive amines come from?

A

These are preformed in cytoplasmic granules (Histamine and Serotonin). Come from mast cells and granulocytes.

17
Q

What are the main cytokines and chemo-kines and where do they come from?

A

Come from lymphocytes and macrophages. They are newly synthesized and include IL-1b, IL-6 and TNFa