HLA

Question 1

Soluble levels of HLA increase in

Answer 1

Infection

Question 2

Soluble levels of HLA decrease in

Answer 2

Malignancy

Question 3

Soluble HLA in blood components

Answer 3

Proportional to number of residual donor lymphocytes and duration of storage

Question 4

Public antigens

Answer 4

Common amino acid sequences in many HLA specificities

Ex HLA-Bw4 and -Bw6 (present in almost all HLA-B molecules)

Question 5

Class I function

Answer 5

Presents endogenous protein- inserted in endoplasmic reticulum

Interact with CD8+ T cells

Question 6

Class II function

Answer 6

Presents exogenous proteins that are taken up by endocytosis

Interact with CD4+ cells

Question 7

Class I expression

Answer 7

Present on most nucleated cells

Except neurons, corneal epithelial cells, trophiblasts, and germinal cells

Question 8

Class II expression

Answer 8

B lymphocytes
Dendritic cells
Intestinal epithelium 
Early hematopoietic cells
Activated T lymphocytes

Question 9

HLA disease association

DR4

Answer 9

Rheumatoid arthritis

Question 10

HLA disease association

DR15/ DQ6

Answer 10

MS

Question 11

HLA disease association

B27

Answer 11

Ankylosing spondylitis

Question 12

HLA disease association

DR17

Answer 12

Graves’ disease

Question 13

HLA disease association

DQ2

Answer 13

Celiac disease

Question 14

HLA disease association

DQ6

Answer 14

Narcolepsy

Question 15

HLA disease association

B35

Answer 15

Subacute thyroiditis

Question 16

HLA disease association

DQ8

Answer 16

Type 1 diabetes

Question 17

HLA disease association

DR8

Answer 17

Juvenile rheumatoid arthritis