8C. Pedigrees

Question 1

Pedigree analysis is used to

Answer 1

determine individual genotypes and predict the mode of transmission of single gene traits

Question 2

Pedigree Analysis Instructions

Answer 2

1. Determine if it’s dominant or recessive.
2. Determine if it’s autosomal or Sex-linked.
3. Assign genotypes to affected individuals first.
4. Assign remaining genotypes to unaffected individuals.
5. Double check

Question 3

If Autosomal, what alleles do we use to show inheritance.

Answer 3

AA, Aa or aa

Question 4

If Sex-linked, what alleles do we use to show inheritance.

Answer 4

XcY, XCY, XcXc, XCXc, XcXC or XCXC

Question 5

How to determine if it’s Y-Linked

Answer 5

only males show the trait

Question 6

Rules for Autosomal dominant

Answer 6

1. If both parents are affected, offspring may be affected
2. If neither parent is affected, offspring must be unaffected
3. If offspring is affected, must be an affected parent

Question 7

Dominant traits

Answer 7

Can’t skip generations

Question 8

Rules for Autosomal recessive

Answer 8

1. If both parents are affected, offspring must be affected
2. If neither parent is affected, offspring must be unaffected
3. If offspring is affected, may be an affected parent

Question 9

Rules for X-Linked recessive

Answer 9

1. If a female is affected, dad must be affected
2. If a female is affected, her sons must be affected
3. If a male is affected, mother may be affected

Question 10

Rules for X-Linked dominant

Answer 10

1. If a male is affected, mum and his daughters must be affected
2. If a female is affected, dad and sons must be affected

Question 11

Recessive traits

Answer 11

Can skip generations