Flashcards in 9. Structure, Function and Disorder of Skin Deck (35)
How does the skin act as a barrier?
The outer epidermis prevents per cutaneous absorption of exogenous substances. It can be overcome during percutaneous absorption of drugs or in some diseases.
What does poor barrier function of the skin lead to?
Loss of fluid, protein, other nutrients and heat. Also excessive absorption of exogenous agents like drugs.
What causes loss of the sensation function of the skin?
Leprosy and diabetic sensory neuropathy.
How does the skin act as a thermoregulator?
Vascular thermoregulation (dilation of skin blood vessels leads to heat loss and constriction leads to heat gain) and thermoregulatory eccrine sweating (evaporation of eccrine sweat causes cooling).