9.1 Anemia (Microcytic) Flashcards by Miguel Acosta

Q

Defined as a decrease in the oxygen-carrying capacity of the blood.

A

Anemia

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Q

The term anemia is derived from the Greek word anaimia, meaning “without blood”

T or F

A

T

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Q

Serum Iron: Decrease
TIBC: Increase
Transferrin saturation: Decrease
Serum ferritin: Decrease
FEP/ZPP: Increase
sTfR: Increase

a. Iron Deficiency Anemia
b. Anemia of Chronic Inflammation
c. Thalassemia
d. Sideroblastic anemia

A

a

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Q

Serum Iron: N
TIBC: N
Transferrin saturation: N
Serum ferritin: N
FEP/ZPP: N
sTfR: N

a. Iron Deficiency Anemia
b. Anemia of Chronic Inflammation
c. Thalassemia
d. Sideroblastic anemia

A

c

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Q

Serum Iron: Decrease
TIBC: Decrease
Transferrin saturation: Decrease
Serum ferritin: Increase
FEP/ZPP: Increase
sTfR: N

a. Iron Deficiency Anemia
b. Anemia of Chronic Inflammation
c. Thalassemia
d. Sideroblastic anemia

A

b

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Q

Serum Iron: Increase
TIBC: Decrease
Transferrin saturation: Increase
Serum ferritin: Increase
FEP/ZPP: Increase
sTfR: N

a. Iron Deficiency Anemia
b. Anemia of Chronic Inflammation
c. Thalassemia
d. Sideroblastic anemia

A

d

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Q

Inadequate intake; increased need, impaired absorption, chronic blood loss

a. IDA
b. Anemia of Chronic inflammation
c. Thalassemia
d. Sideroblastic anemia

A

a

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Q

In IDA

Acute blood loss = Normocytic anemia
Chronic = Microcytic

T or F

A

t

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Q

In IDA (Iron Depletion

Storage iron depletion

a. Stage 1
b. Stage 2
c. Stage 3

A

a

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Q

In IDA (Iron Depletion

Functional iron depletion

a. Stage 1
b. Stage 2
c. Stage 3

A

c

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Q

In IDA (Iron Depletion

Transport iron depletion

a. Stage 1
b. Stage 2
c. Stage 3

A

b

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Q

In IDA (Iron Depletion

When Stored iron is depleted, it is reflected by serum ferritin, resulting to a decreased serum ferritin level

a. Stage 1
b. Stage 2
c. Stage 3

A

a

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Q

In IDA (Iron Depletion

Reflected by a Decreased serum iron

a. Stage 1
b. Stage 2
c. Stage 3

A

b

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Q

In IDA (Iron Depletion

Reflected by low levels / decreased hemoglobin iron

a. Stage 1
b. Stage 2
c. Stage 3

A

c

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Q

Symptoms: Glossitis, pica, koilonychias

a. IDA
b. Anemia of Chronic inflammation
c. Thalassemia
d. Sideroblastic anemia

A

a

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Q

Rheumatoid arthiritis, chronic infections, and malignancies

a. IDA
b. Anemia of Chronic inflammation
c. Thalassemia
d. Sideroblastic anemia

A

b

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Q

Production of Acute-Phase Reactants - which inhibit iron utilization

a. IDA
b. Anemia of Chronic inflammation
c. Thalassemia
d. Sideroblastic anemia

A

b

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Q

Inhibits ferroportin whih promotes intestinal iron absorption and iron release

Increase during inflammation

a. Hepcidin
b. Lactoferrin

A

a

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Q

Competes with transferrin in binding iron

a. Hepcidin
b. Lactoferrin

Study These Flashcards

A

b

Q

NOTE: in anemia of chronic inflammation:

increase of ferritin meaning more stored iron however, the presence of inhibitor prevents using this stored iron (Hepcidin) which is increased in chronic inflammation

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A

Q

Reduced or absent synthesis of one or more globin chains of hemoglobin (Quantitative defect)

a. IDA
b. Anemia of Chronic inflammation
c. Thalassemia
d. Sideroblastic anemia

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A

c

Q

Hemoglobin synthesized:
- Hemoglobin Bart’s
- Hemoglobin H

a. Alpha thalassemia
b. Beta thalassemia

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A

a

Q

In Alpha Thalassemia, Hemoglobin synthesized:
- Hemoglobin Bart’s - Usually seen in newborns
- Hemoglobin H - Usually seen in adults

T or F

Study These Flashcards

A

T

Q

In Alpha Thalassemia, Hemoglobin synthesized:

Hemoglobin Bart’s - 4 ________ globin
Hemoglobin H - 4 ________ Globin chains

Study These Flashcards

A

Gamma

Beta

Defective genes: 1 (-aa/a) a. a-thalassemia silent carrier b. a-thalassemia minor c. Hemoglobin H disease d. Hemoglobin Bart

a

Defective genes: 4 (--/--) a. a-thalassemia silent carrier b. a-thalassemia minor c. Hemoglobin H disease d. Hemoglobin Bart

d

Defective genes: 3(--/-a) a. a-thalassemia silent carrier b. a-thalassemia minor c. Hemoglobin H disease d. Hemoglobin Bart

c

Defective genes: 2(--/aa) a. a-thalassemia silent carrier b. a-thalassemia minor c. Hemoglobin H disease d. Hemoglobin Bart

a

No hematologic abnormality a. a-thalassemia silent carrier b. a-thalassemia minor c. Hemoglobin H disease d. Hemoglobin Bart

a

Fetal or neonatal death with severe anemia a. a-thalassemia silent carrier b. a-thalassemia minor c. Hemoglobin H disease d. Hemoglobin Bart

d

Chronic hemolytic anemia a. a-thalassemia silent carrier b. a-thalassemia minor c. Hemoglobin H disease d. Hemoglobin Bart

c

Asymptomatic, mild anemia a. a-thalassemia silent carrier b. a-thalassemia minor c. Hemoglobin H disease d. Hemoglobin Bart

b

Hydrops Fetalis a. a-thalassemia silent carrier b. a-thalassemia minor c. Hemoglobin H disease d. Hemoglobin Bart

d

Symptoms appear at 6-24 months of age a. Alpha thalassemia b. Beta thalassemia

b

Symptoms appear at 6-24 months of age a. Alpha thalassemia b. Beta thalassemia

b

Hemoglobin synthezed: Hemoglobin F Hemoglobin A2 a. Alpha thalassemia b. Beta thalassemia

b

Asymptomatic; Normal hematologic parameters a. b-thalassemia silent carrier b. b-thalassemia minor c. Thalassemia intermedia d. Thalassemia major

a

Asymptomatic; Mild anemia a. b-thalassemia silent carrier b. b-thalassemia minor c. Thalassemia intermedia d. Thalassemia major

b

Transfusion dependent; Severe anemia a. b-thalassemia silent carrier b. b-thalassemia minor c. Thalassemia intermedia d. Thalassemia major

d

Non-transfusion dependent; mild to moderate anemia a. b-thalassemia silent carrier b. b-thalassemia minor c. Thalassemia intermedia d. Thalassemia major

c

Cooley’s anemia a. b-thalassemia silent carrier b. b-thalassemia minor c. Thalassemia intermedia d. Thalassemia major

d

Causes: Interference in heme synthesis; Defective iron incorporation to developing RBCs a. IDA b. Anemia of Chronic inflammation c. Thalassemia d. Sideroblastic anemia

d

In Sideroblastic anemia, presence of ringed sideroblast in the ___________

Bone marrow

What causes acquired sideroblastic anemia

Lead poisoning

What causes Inherited sideroblastic anemia?

Porphyria