9.1 Blood Component PReparation

Question 1

Use of Transfusion therapy:

Inadequate Oxygen carrying capacity because of _________________

Insufficient coagulation proteins or platelets to provide adequate hemostasis

Answer 1

Anemia or Blood loss

Question 2

2 types of Blood Collection:

Collection of Blood in a sterile container

Answer 2

Close system

Question 3

2 types of Blood Collection:

Collection or exposure to air through an open port that would shorten the expiration because of potential bacterial contamination

Answer 3

Open system

Question 4

What is the expiration for open system RBC?

Answer 4

24 hours

Question 5

What is the expiration for open-system platelets

Answer 5

4 hours

Question 6

Platelet concentrate is stored at what temp?

Answer 6

Room temp

Question 7

The Goal of RBC Preservation is to provide viable and functional blood components for patients requiring blood transfusion

T or F

Answer 7

T

Question 8

FDA requires an average of ____ hour post transfusion for RBC preservation which allows RBC survival of more than ____%

Answer 8

24, 75

Question 9

For RBC Preservative Anticoagulant:

What is the Storage time for:

Acid-Citate-Dextrose (ACD)

Answer 9

21 days

Question 10

For RBC Preservative Anticoagulant:

What is the Storage time for:

Citrate-Phosphat-Dextrose (CPD)

Answer 10

21 Days

Question 11

For RBC Preservative Anticoagulant:

What is the Storage time for:

Citrate-Phosphate-Double-Dextrose (CP2D)

Answer 11

21

Question 12

For RBC Preservative Anticoagulant:

What is the Storage time for:

Citrate-Phosphate-Adenine (CPDA-1 and 2)

Answer 12

35

Question 13

RBC preservative that Allows RBC to store for 10 years

Answer 13

Frozen RBC

Question 14

Benefits of RBC Additive Solutions:

Extends the Shelf-life of RBC to __ days by adding nutrients

Answer 14

42

Question 15

Benefits of RBC Additive Solutions:

Produces an RBC concentrate of ___________ viscosity that is easier to infuse

Answer 15

Lower

Question 16

Benefits of RBC Additive Solutions:

Allows harvesting of more plasma and platelets from the unit

T or F

Answer 16

T

Question 17

What do you call the fluid inside the mother and daughter bags

Answer 17

Anticoagulant preservative

Question 18

Additive solution is usually found in the ______ satellite bag

Answer 18

Last

Question 19

Additive solution is added AFTER the removal of Plasma

T or F

Answer 19

T

Question 20

Additive solutions:

Adsol (AS-_)
Nutricel (AS-__)
Optisol (AS-_)
SOLX (AS-_)

Answer 20

1,3,5,7

Question 21

Additive solution allows to extend life of RBC or blood up to?

Answer 21

42 days

Question 22

The additive solution must be added within ___ hours of WBC

Answer 22

72

Question 23

When Adding Additive solution

_____mL for a 450mL blood
_____ mL for a 500mL blood

Answer 23

100
110

Question 24

Chemicals in anticoagulant solution

Chelates Calcium

a. Citrate
b. Monobasic sodium phosphate
c. Dextrose
d. Adenine
e. Mannitol

Answer 24

a

Question 25

Chemicals in anticoagulant solution Maintains pH during Storage a. Citrate b. Monobasic sodium phosphate c. Dextrose d. Adenine e. Mannitol

Answer 25

b

Question 26

Chemicals in anticoagulant solution Production of ATP a. Citrate b. Monobasic sodium phosphate c. Dextrose d. Adenine e. Mannitol

Answer 26

d

Question 27

Chemicals in anticoagulant solution Substrate for ATP a. Citrate b. Monobasic sodium phosphate c. Dextrose d. Adenine e. Mannitol

Answer 27

c

Question 28

Chemicals in anticoagulant solution Protect against storage-related hemolysis a. Citrate b. Monobasic sodium phosphate c. Dextrose d. Adenine e. Mannitol

Answer 28

e

Question 29

Process by which ATP and 2,3 DPG levels are restored or enhance by metabolic alterations

Answer 29

Rejuvenation solution

Question 30

Process of reviving RBC

Answer 30

Rejuvenation solution

Question 31

What are the Rejuvenation Solutio?

Answer 31

PIGPA Pyruvate Inosine Glucose Phosphate Adenine

Question 32

The only FDA approved rejuvenation solution

Answer 32

Rejuvesol

Question 33

RBC storage Lesions: Percent of viable cells Glucose ATP pH 2,3 -DPG Decrease or Increase

Answer 33

Decrease

Question 34

RBC storage Lesions: Plasma potassium Plasma hemoglobin Lactic acid Decrease or Increase

Answer 34

Increase

Question 35

in RBC storage lesions Oxgen Dissociation curve is Shift to the right or left?

Answer 35

Shift to the Left

Question 36

Pathogen Reduction technology includes UV irradiation and Photo sensitizers Psoralen Treatment Decrease the the risk of transmissble blood disease T or F

Answer 36

T

Question 37

Removal of WBCs from blood or blood components prior to transfusion

Answer 37

Leukoreduction

Question 38

Leukoreduction are given to patient with Anti-WBC T or F

Answer 38

T

Question 39

Febrile nonhemolytic transfusion reaction Transfusion Related acute lung injury Both of this requires leukoreduce T or F

Answer 39

T

Question 40

Residual WBC per each whole blood, RBC or apheresis Platelet <5.0 x 10^6 <8.3 x 10^5 >85%

Answer 40

<5.0 x 10^6

Question 41

_____ of the original component must be recovered after leukoreduction <5.0 x 10^6 <8.3 x 10^5 >85%

Answer 41

85%

Question 42

Residual WBC per each Platelets derived from whole blood <5.0 x 10^6 <8.3 x 10^5 >85%

Answer 42

<8.3 x 10^5

Question 43

Leukoreuduction categories: Shortly after collection a. Prestorage b. Post-storage

Answer 43

a

Question 44

Leukoreuduction categories: Shortly after collection a. Prestorage b. Post-storage

Answer 44

a

Question 45

Leukoreuduction categories: At the patient's bedside a. Prestorage b. Post-storage

Answer 45

b

Question 46

Filters is made up of multiple layers of Polyester or cellulose acetate nonwoven fibers that trap leukocytes and platelets T or F

Answer 46

T

Question 47

Pore size: 17um Removes fibrin clot First generation Filters second generation Filters Third generation filters

Answer 47

First

Question 48

Pore size: 20-40um Removes micro aggregates First generation Filters second generation Filters Third generation filters

Answer 48

Second

Question 49

Removes 99.9% WBC First generation Filters second generation Filters Third generation filters

Answer 49

Third

Question 50

Pther methods to acheive RBC leukoreduction:

Answer 50

Centrifugation Washing Freezing Thawing Deglycerolizing