Food Allergy and Anaphylaxis

Question 1

marker for anaphylaxis

Answer 1

serum tryptase

Question 2

anaphylaxis DDX

Answer 2

Question 3

How can food allergy be prevented

Answer 3

early introduction in high risk children.

Question 4

Why can some times food allergies be mitigated by eating processed version of the food?

Answer 4

sometimes high heat can mess up the conformational epitope, and IgE antibodies in the blood produced by plasma/bcells cannot recognize it.

Question 5

pros and cons of a food igE test

Answer 5

high sensitivty = low chance of a false negative. Negative test helpful to exclude allergy.

LOW specificity = high chance of a false positive. better to rule out than to confirm. test results are therfore helpful to guide allergy diagnosis but are not definitive.

Question 6

Adult onset multiple food allergies due to oral allgery syndrome. How does this happen? What type of allergens does this usually affect?

Answer 6

Question 7

acute management for anaphylaxis. What is a substitute for epinephrine if the person is on beta blockers

Answer 7

1. epinephrine.
2. oxygen and. inhaled bronchodilator
3. fluid resuscitation for refractory hypotension.
4. H1 and H2 antihistmaines (but this takes longer and is useless if the kid is going into bronchospasm and hypotension). it’s good for the hives tho.
5. corticosteroid

* if person is taking beta blockers and isn’t super responsive to epinephrin, consider glucagon.