Pharmacology COPY Flashcards

1
Q

Name a H2 receptor antagonist used to treat peptic ulcer disease

A

Ranitidine

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2
Q

Name a proton pump inhibitor

A

Omeprazole

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3
Q

Which drug may reduce the effects of long-term NSAID treatment?

A

Misoprostolol (PGE1 analogue)

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4
Q

What side effects can a NSAID have on the GI tract?

A

Gastric bleeding

Mucosal ulceration

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5
Q

Why do NSAIDs cause gastric ulceration and bleeding?

A

Inhibit COX enzyme and thus block PGE formation - PGE reduces gastric acid secretions

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6
Q

What are the 3 main aims of drug treatment for peptic ulcers?

A

Decrease gastric secretions
Increase mucosal resistance
Eradicate H. pylori

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7
Q

What do proton pump inhibitors block?

A

The proton pump on the apical membrane (NOT the ones in tubulovesicles)

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8
Q

Name two mucosal strengtheners

A

Sucralfate

Bismuth chealate

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9
Q

Name 2 anti-emetic agents that are antagonists of the 5-HT3 receptor

A

Ondansetron

Palonosetron

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10
Q

Ondansetron (5-HT3 antagonist) is effective in reducing vomiting in chemotherapy patients, but has no effect on motion sickness. True/False?

A

True

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11
Q

Name a muscarinic ACh antagonist that can be used to treat motion sickness

A

Hyosine

Scopolamine

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12
Q

Name a H1 antagonist that can be used to treat motion sickness + nausea/vomiting caused by irritants

A

Cyclizine

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13
Q

Name a dopamine antagonist used for drug-induced and GI disease -induced vomiting

A

Metoclopramide

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14
Q

Name an NK1 antagonist used in conjunction with 5-HT3 antagonist in highly emetogenic chemotherapy

A

Aprepitant

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