Tuberculosis Flashcards

1
Q

Which bacteria is the commonest cause of TB?

A

Mycobacterium tuberculosis

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2
Q

What is the primary test for TB?

A

PCR

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3
Q

TB involves non-caseating necrosis. True/False?

A

False

It is caseating

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4
Q

What is interferon gamma testing re TB?

A

Measures how much IFG is released from T cells in response to stimuli (MTB)

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5
Q

Which 4 drugs are used for TB?

A

Rifampicin
Isoniazide
Pyrazinamide
Ethambutol

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6
Q

Start of with 4 months on RI, then 2 months on PE. True/False?

A

False

2 months on RIPE, then 4 months on RI

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7
Q

If patient has TB affecting CNS, what is the treatment course?

A

2 months on RIPE, then 10 months on RI

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8
Q

List some adverse reactions of Rifampicin

A

Hepatitis
Orange-red urine
Flu syndrome

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9
Q

List some adverse reactions of Isoniazide

A

Hepatitis

Peripheral neuropathy

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10
Q

List some adverse reactions of Pyrazinamide

A

Hepatitis
Anorexia, vomiting
Hyperuricaemia

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11
Q

List some adverse reactions of Ethambutol

A

Colour blindness, developing into blindness

Arthralgia

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12
Q

What proportion of the world population is affected by TB?

A

1/3

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13
Q

Which components make up the necrosis in TB?

A

Epitheloid cells and Langhan’s giant cells, causing formation of Ghon focus

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14
Q

When might the Mantoux/tuberculin skin test for TB be false negative?

A

If patient has had a BCG vaccination

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