Lecture 7: structural basis of hemoglobin Flashcards
1
Q
the Bohr effect is ___ which lowers the pH; this results in ____
A
the Bohr effect is the acidification of peripheral tissue [buildup of CO2 in the muscle] which lowers the pH; this stabilizes the deoxy Hb which results in O2 being released more readily
2
Q
BPG stabilizes the (oxy/ deoxy) form of Hb
A
BPG stabilizes the deoxy form of Hb
3
Q
interactions with BPG are (strengthened/ weakened) in fetal Hb
A
interactions with BPG are weakened in fetal Hb
4
Q
BPG binds tighter to (fetal/ adult) Hb
A
BPG binds tighter to adult Hb
5
Q
sickle cell anemia
A
= mutation in gene coding for Hb-beta that results in a GLU6 - Val amino acid substitution
6
Q
(de/ oxy) HbS has complimentary hydrophobic patch in sickle cell anemia
A
deoxy HbS has complimentary hydrophobic patch
