L1 - Intro Flashcards
When does neural patterning and neurogenesis occur in humans
4-12 weeks
How do cells become more specialised?
changes in gene expression
What is gene expression governed by?
extrinsic factors - morphogens
intrinsic factors - transcription factors
What causes the AP axis regionalisation of the neural tube?
Retinoic acid gradient
What does the retinoic acid gradient induce?
different patterns of Hox transcription factors
What does in situ hybridisation detect?
mRNA
What is Shh?
morphogen
What axis does Shh pattern?
DV
What does the transcription factor code dictate?
later differentiation
What establishes progenitor domains in the spinal cord?
opposing gradients of Shh and BMPs/Wnts
Which way do neural crest cells migrate?
laterally
What does the position of progenitors dictate
position and type of differentiated neuron
How can neuronal character be understood?
Cartesian grid pattern
