Helicobacter Pylori Flashcards
What are the bacterial characteristics of H.Pylori
Gram Negative
Spiral shaped
at what stage in there life so most people aquire H.Pylori
Childhood
What % of population does H.Pylori infect
50%
What type of epithelium does H.Pylori colonise in
Gastric type Mucosa
Where in the gastric type mucosa does H.Pylori reside
The surface mucous layer
Does H.Pylori penetrate the epithelial layer
NO
How does H.Pylori survive the acidic environment of the stomach
H.Pylori produces UREASE which reduces the pH of its surrounding environment.
How does Urease produced by H.Pylori reduce the pH of its surrounding environment
Urease convers Urea into ammonia and Co2
Ammonia neutralises the acid
What diseases can H.Pylori cause and how common are they (%) ?
Chronic gastritis (>80%) Chronic atrophic gastritis and intestinal metaplasia (15-20%) Gastric or duodenal ulcer (15-20%) Gastric cancer (<1%)
How do you diagnose a H.Pylori infection non-invasively
Serology for IgG
Urea breath test
Stool antigen test
What is a urea breath test
A small amount of urea is ingested in a tablet and if urease is present in the stomach then Co2 will be released. It can be picked up on breathing
How do you diagnose a H.Pylori invasively
Endoscopy
For biopsy/rapid slide urea test
What is a rapid slide urea test
Sample taken from endoscopy biopsy is put on a slide with Urea.
Red - positive
Yellow - negative
What is treatment called for H.Pylori infection
Eradication therapy
How long does eradication therapy last
7 days
