Introduction to Diagnostic Drugs Flashcards

1
Q

What are mydriatics?

A

Drugs used to dilate the pupil

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Why is there an increased use of mydriatics in optometric practices?

A
  • Expansion of co-management schemes (shared care schemes)
  • There is an increase in professional negligence cases so stronger evidence of diagnoses is needed.
  • Better appreciation of the benefits of dilation.
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

When would you dilate a pupil?

A
  • When px have Conditions such as e.g. diabetes, uveitis, pigmented fundus lesion, suspected glaucoma, peripheral retinal degeneration, hypertension (high blood pressure), cataract, age-related macular degeneration, history of retinal detachment, history of metastatic cancer.
  • If Px shows Symptoms of e.g. flashes and floaters, new distortion, unexplained loss of vision, recent blunt force trauma.
  • When there is a Relevant family ocular history
  • When Px has Small pupils, nystagmus, unsteady fixation -Where stereoscopic view of retina is necessary
  • To check Systemic medications with potential side effects
  • To get good fundus photograph
  • Generally, when you need to get a really good/better/stereoscopic view!
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Is dilation important to spot conditions?

A

Arguably yes -A study found Ability of ophthalmoscopy to grade correctly diabetic retinopathy is more than 50% higher in dilated pupils than undilated pupils.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Which Mydriatics are typically used by optometrists (3)?

A
  • Tropicamide 0.5%
  • Tropicamide 1.0%
  • Phenylephrine 2.5%

[Tropicamide is the most commonly used]

[All available in minims - basically single use plastic files - advantage is that they can all be kept sterile as a result]

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

When using any drug, the College of Optometrists guidelines state:

A
  • Optometrists should record the batch number and expiry date of drugs that are used in their professional practice
  • Also record drug name, concentration and time instilled (as different drugs have different recovery times).

This will facilitate verification that:

  • Drug is in date,
  • In the case of a drug recall – makes it easier to trace all patients who may have been affected
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What precautions do we need to take before Mydriasis (before dilating pupil)?

A
  • Explanation to patient:
  • Why dilating,
  • effects of dilation
  • Duration of dilation
  • Need to take note of Previous experience of dilation
  • Need to take note of Medical history
  • E.g. phenylephrine: caution in patients with cardiovascular disease, hypertension.
  • Need to be aware of if it might be affected by Current medication or interfere with current medication
  • Need to measurement of IOP and take an Assessment of risk of angle closure.
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is angle closure glaucoma?

A

A type of glaucoma in which the anterior chamber angle through which aqueous humour flows, becomes blocked.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What will happen to the patient in an acute attack of angle closure glaucoma (ACG)?

A

Px will be in pain

Px will experience red eye

Cornea looks hazy around edges.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Why are we so concerned with acute angle glaucoma when using mydriatics?

A

Theres evidence to suggest the two are linked.

Mydriatic drops may be linked to an acute attack of angle closure glaucoma.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

If a patient has a suspected retinal detachment, wet AMD etc and you cannot obtain sufficient view - what must you do?

A

You must either dilate, or refer on worst case scenario.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What are tests that can be done to assess the risk of angle closure?

A
  • Van Herick
  • (Flashlight test)
  • (Smith’s slit-length method)
  • Methods using pachymeters)
  • Gonioscopy

(Ones in brackets aren’t commonly used)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What advice do you give your patients regarding mydriasis?

A
  • They will experience a Loss of acuity (blurriness their accommodation will be off)
  • They might experience Glare problems (Biggest problem with drops):
  • patient may benefit from wearing sunglasses
  • patient may wish to bring sunglasses with them to the examination
  • Px may experience Driving difficulties
  • Make Px aware of symptoms of an acute ACG attack
  • Give information sheet

ALWAYS GIVE WRITTEN AND VERBAL INFORMATION

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What are the general guidlines for driving after dilation?

A

Patients should be given an information sheet, and recommended not to drive for the rest of the day.

College of Optometrists’ Information sheet says that “It is recommended that driving should be avoided whilst your vision is affected.”

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is tropicamide?

A

An anti-muscarinic drug which causes mydriasis by relaxing the sphincter muscle of the iris and cycloplegia by relaxing the ciliary muscle

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is cycloplegia?

A

The blocking of accommodation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What are the timings for tropicamide?

A
  • Onset of action = approx 10 to 30 minutes
  • Maximum effect = within approx 20 to 40 minutes
  • Recovery to normal = approx 4 to 9 hours
  • BUT INDIVIDUAL RESults are variable
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Why do optometrists prefer tropicamide over any other mydriatic?

A

 Very few allergic reactions

 Only isolated adverse systemic reactions reported e.g. CNS effects can occur with cyclopentolate

19
Q

When using tropicamide what does the optom have to be careful of?

A

 Risk of ACG in predisposed eye

 Be careful of possible interactions with other anti-muscarinics

20
Q

What is phenylephrine and when may it be used?

A
  • A sympathomimetic (mimics sympathetic nervous system) drug which causes mydriasis by stimulating the dilator muscle of the iris
  • Mydriasis is not complete -Light reflex is not abolished
  • May be used in combination with tropicamide in patients who are difficult to dilate.
21
Q

What are the timings for phenylephrine?

A
  • Onset of action = approx 10 to 30 minutes
  • Maximum effect = within approx 30 to 90 minutes
  • Recovery to normal = approx 5 to12 hours

BUT INDIVIDUAL RESPONSES TO DRUGS ARE VERY VARIABLE

22
Q

What are contraindications for the use of phenylephrine?

A

According to the manufacturers (Chauvin Pharmaceuticals) the use of phenylephrine minims is contraindicated in a range of conditions which include:

  • Vascular hypertension
  • Long-standing insulin-dependent diabetes
23
Q

When should phenylephrine be used with caution?

A

Any diabetic

Long-standing bronchial asthma

Cerebral arteriosclerosis

24
Q

What are cycloplegics?

A
  • Drug used to produce “cycloplegia” -paralysis or partial paralysis of ciliary muscle i.e. accommodation is disabled
25
Q

When are cycloplegics used?

A

Used if there are indications of fluctuating or excessive accommodation during refraction

Used mainly in children when their accommodation is unstable, making retinoscopy unreliable

Young latent hypermetropes.

26
Q

True or false- Tropicamide and cyclopentolate are both cyclopegic agents, but cyclopentolate is more effective at disabling accommodation in young people.

A

True –> Tropicamide and cyclopentolate are both cyclopegic agents, but cyclopentolate is more effective at disabling accommodation in young people.

27
Q

What is cyclopentolate and how does it work?

A

It is an anti-muscarinic drug (like tropicamide) which causes cycloplegia by relaxing the ciliary muscle (and mydriasis by relaxing the sphincter muscle of the iris)

It is used widely for cycloplegia, not as a mydriatic

28
Q

What are the timings for cyclopentolate?

A

Onset of action = approx 10 to 30 minutes

Maximum effect = within approx 20 to 60 minutes

Recovery to normal = within 24 hours

BUT INDIVIDUAL RESPONSES TO DRUGS ARE VERY VARIABLE

29
Q

What is latent hypermetropia?

A

Someone that is actually hyperopic but because they are constantly accommodating we don’t pick it up.

30
Q

What concentrations do we get cyclopentolate in and when do we use each one?

A

 Available in Minims 0.5% and 1.0%

 Tend to use 1% Minims in under 12s and 0.5% in children aged 12 and over

31
Q

True or false - Iris colour affects cyclopentolate course of action.

A

True

Effects of iris colour (applies to all mydriatics and cycloplegics)

  • Drug binds with melanin on the iris and is slowly released:
  • In dark irides this leads to slower onset of action and longer duration of action

This applies to all mydriatics

32
Q

When using cyclopentolate what do you want to consider?

A

Px age

Px iris colour

33
Q

True or false-  More likely to get CNS effects with tropicamide than with cyclopentolate

A

False—> More likely to get CNS effects with cyclopentolate than with tropicamide

34
Q

True or false - the darker the irides the larger the concentration of mydriatic you use?

A

True

35
Q

What are local anaesthetics used to do?

A

 Used to anaesthetise the cornea and conjunctiva

36
Q

What are the two types of ocular local anaesthetics- give examples of each?

A

The ester type of which the examples are:

 Tetracaine (amethocaine) hydrochloride 0.5%

 Oxybuprocaine hydrochloride (benoxinate) 0.4%

 Proxymetacaine hydrochloride 0.5%

The amide type of which the example is:

 Lidocaine 4%

[May be used in case of previous toxic reaction to ester anaesthetic]

37
Q

Why may you use ocular local anaesthetic?

A

Gold Man Tonometry

38
Q

How quickly do ocular local anaesthetics work?

A

 Complete anaesthesia within 1 minute (usually ~20 seconds)

39
Q

What is time for recovery of ocular local anaesthetic like?

A

Very variable but typically 25 mins.

40
Q

What must you let your px know when installing ocular local anaesthetics?

A

Will briefly sting on instillation

Warn px not to rub eyes during this time.

41
Q

What do you want to check for after having installed ocular local anaesthetics?

A

Ocular local anaesthetics may cause toxic reaction – check for staining before leaving.

42
Q

What are the Effects of prior instillation of a local anaesthetic?

A

 Corneal penetration of any other drug is increased

 Some optoms. instil a local anaesthetic before instilling tropicamide (or phenylephrine) to dilate the pupil

 This gives a quicker response and can lead to a bigger pupil

[Anaesthetics increase penetration of any other drug]

43
Q

What is Fluorescin used in?

A

Contact applanation tonometry

 Goldmann

Contact lens fitting

Assessing corneal damage

etc

44
Q

Why is Oxybuprocaine hydrochloride preferred over Proxymetacaine hydrochloride for use in anaesthetising the cornea?

A

Proxymetacaine hydrochloride needs to be stored in a fridge whereas oxybuprocaine does not - making it more convenient.