PEDS Tumer Flashcards
1
Q
Mock common age of neuroblastoma
A
1-4 years
2
Q
Most common site of neuroblastoma
A
Adrenal medulla
3
Q
Histology of neuroblastoma
A
Dark blue round cell
Rosette formation
4
Q
Spread by
A
Local extension and encasement
5
Q
Metastasis to
A
LN ,bones
Bone marrow
Liver and skin
6
Q
The shimada system classification based on
A
Mitosis karyorrhexis index
Age
Degree of differentiation
Stroma rich stroma poor
7
Q
Favourable prognosis SS calcification
A
Infant
Well differentiate
Low MKI
8
Q
Cytogenetic and prognostic
A
Poor: MYCN gene amplifications ,DNA ploidy ,multi drug resistance protein
Good : TRCA ,CD44,,H- ras
Ch17q gain ,ch1p deletion
9
Q
Lab in neuroblastoma
A
Investigations ↑↑ Vanillylmandelic acid (VMA) and homovanillic acid (HVA) in urine urinary metabolites of catecholamines ↑ ferritin ↑ lactate dehydrogenase (LDH) ↑ Neuron specific enolase (NSE)
10
Q
AXR of neuroblastoma
A
Tumor calcification
11
Q
US
A
Solid vs cystic
