uworld deck 8

Question 1

what prevents break down of newly synthesized fatty acids

Answer 1

malonly co a inhibits cat

Question 2

wound dehnisence
contractions
ulcerations

Answer 2

causes of wound dehisence =
rupture of previos wound , inadequate contraction, granulation and mechanical stres

ulceration of wound -inadq vasuclarization

when do contractures occur=increased mmp actiity results in excesive contaction

Question 3

type 4 reaction vs delayed reaction of anaphlaxis

Answer 3

4 days vs 4 hours

Question 4

vertebral antomy

Answer 4

anterior vertebra-bodies
posterior-middle spinous process,ttransverse/fascet
posterior vertebral arch-pedicle and lamina and pars reticularisa.
in thorax facets of transverse vetebrae articulate with the ribs

Question 5

prostatic plexus

Answer 5

In fascia of prostate > originates from inferior hypogastric plexus
• Contains lesser and greater cavernous nerves
• Carries post ganglionic parasympathetic fiber
• Damage during postatectomy can result in ED

Question 6

what part of ecoli responsible for sepsis

what part responsible for meningits

Answer 6

lipid a

capsule

Question 7

functin of thyroid peroxidase

Answer 7

Oxidation of Iodide to Iodine
• Iodination of thyroglobulin
• Coupling between 2 iodized tyrosine residues

Question 8

where is t4 produced and where is t3 produced

Answer 8

t4 in the thyroid gland converted to t3 peripherally in the tissues by deiodinase

Question 9

polymorphisms

Thiopurine methyltransferase

Answer 9

Generally deactivate drugs, but some drugs metabolites are the active form • Polymorphisms exist > poor, intermediate and rapid metabolizers
• Tamoxifen: prodrug that gets activated by CYP2D to become endoxifen (poor metabolizers = less effective drug)
n acetyltransferase

Inactivates 6• mercaptopurine
• Def increases toxicity p glycoprotein • Efflux pump causing multidrug resis

Question 10

mesentric necrosis

pertonitis

Answer 10

dusky red and congested. Subserosal ecchymoses, edema and/or well-defined areas of necrosis may be present.

dull-appearing peritoneal surface with areas of viscous white-yellow suppurative exudate.

srosa and mesentry in celiac-normal

Question 11

explain bronchopulmonary dysplasia

Answer 11

broncopulmonary dysplasia
tachypena,MV and retractions
lung injury—fibrosis
arrest in development—- low alveoli and capillaries

always diagnosed greater than 1 month

Question 12

mitral valvue murmur

Answer 12

diastolic murmur with presystolic accentuation due to atrial contraction. With mild stenosis, the murmur may only be audible during the accentuation phase in late diastole; atrial fibrillation may cause the murmur to disappear completely.

Question 13

can a paradoxical embolism occur in patients with net left to right shunt

Answer 13

mportantly, a paradoxical embolism can occur even in patients with net left-to-right shunting due to transient reversal of the shunt during periods of elevated right-sided pressure (eg, early ventricular systole, straining during coughing or defecation).

Question 14

what are the calcium levels in colon cancer and pth olevel

Answer 14

colon cancer could be associated with hypercalcemia however

bone metastasis

Question 15

what is adjustment disorder

Answer 15

ithin 3 months of the onset of the stressor with associated marked distress (

Question 16

what is camp factor

Answer 16

Production of CAMP factor, a phospholipase that enhances the activity of beta-hemolysins secreted by certain strains of Staphylococcus aureus. T

Question 17

common cause of early neonatal sepsis associated with classic galactosemia

Answer 17

ecoli

Question 18

what can lack of tubles cause

Answer 18

Lack of t tubules results in uncoordinated contration

Question 19

kawaskai vs handfood mouth

Answer 19

targetoid vs vesicular