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Pharmacology Basics > Pharma MCQ 8 > Flashcards

Pharma MCQ 8 Flashcards

1
Q

BG Coefficient: Xenon

A

0.2

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2
Q

BG Coefficient: Desflurane

A

0.42

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3
Q

BG Coefficient: N2O

A

0.47

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4
Q

BG Coefficient: Isoflurane

A

1.4

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5
Q

BG Coefficient: Halothane

A

2.5

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6
Q

Which of these have a BG Coefficient > 1?

Xenon, Desflurane, Nitrous Oxide, Isoflurane, Halothane

A

Isoflurane and Halothane

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7
Q

How does thiopental exert its effect on respiration?

A

Thiopental causes respiratory depression by a direct effect on the respiratory centre in the medulla rather than on peripheral chemoreceptors.

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8
Q

Thiopental protein binding?

A

80%

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9
Q

Thiopental metabolism and clearance?

A

Its action is terminated by redistribution

and hepatic metabolism is SLOW.

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10
Q

Resistance to non-depolarising relaxants may be produced by:

  1. hypothermia
  2. phenytoin
  3. lithium
  4. hypocalcaemia
  5. carbamazepine
A

Phenytoin and Carbamazepine

Resistance to aminosteroid neuromuscular blockers can occur with chronic medication with anticonvulsants phenytoin and carbamazepine.

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11
Q

Which is more potent, lidocaine or ropivocaine?

A

Ropivocaine is 4 times more potent.

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12
Q

Plasma binding cocaine?

A

98%

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13
Q

Plasma binding amethocaine?

A

75%

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14
Q

Prilocaine, ester or amide?

A

Amide

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15
Q

Effect of metabolic products of prilocaine?

A

O-Toluidine

  • allergic reaction
  • reduces Hb
  • methaemoglobinaemia in high doses
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16
Q

Can prilocaine be used for obstetric epidural anaesthetist?

A

NO, AVOID.

Prilocaine should be avoided for obstetric anaesthesia because fetal haemoglobin is more susceptible to methaemoglobin formation

17
Q

TCA, mechanism of action?

A

Tricyclic antidepressants have several actions including inhibiting presynaptic re-uptake:

  • norepinephrine
  • epinephrine
  • 5-hydroxytryptamine (serotonin)

but do not affect metabolism per se.

18
Q

How do benzodiazepines effect brain physiology?

A

Benzodiazepines are relatively lipid soluble and penetrate the blood brain barrier readily.

> > > DOSE RELATED: decrease cerebral blood flow and cerebral oxygen consumption.

19
Q

True or false: Benzo have depressant effects dull after long-term use?

A

True,

long-term use -> tolerance.

20
Q

ICP in a ventilated patient is increased by which of the following:

  1. Desflurane
  2. Nitrous oxide
  3. Fentanyl
  4. Vecuronium
  5. Ketamine
A

Desflurane - vasodilation above MAC 1

Ketamine - increases CBF and ICP

Pharmacology Basics (25 decks)

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