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TOB II > Session 10 > Flashcards

Session 10 Flashcards

1
Q

What can Haemopoietic progenitor differentiate into in Haemopoiesis?

A 
Myeloid blast (blood cells)
Lymphoid blast (immune cells)
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2
Q

What controls how Haemopoitetic progenitors differentiate?

A

Specific Cytokines

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3
Q

What are the 5 types of WBC?

A 
Neutrophil
Eosinophil
Basophil
Monocyte
Lymphocyte
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4
Q

What is the function of Neutrophils?

A

Phagocytosis

Increased production by G-CSF

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5
Q

What is the function of Eosinophils?

A

Phagocytosis

Release cytotoxic particles to damage larger particles

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6
Q

What is the function of Basophils?

A

Mediate acute inflammation responses by releasing heparin and histamine

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7
Q

What is the function of Monocytes?

A

Migrate to become macrophages in many organs of the body

Phagocytosis and interact with T cells

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8
Q

What is the function of Lymphocytes?

A

B: humoral immunity. Stimulated by antigens, transform into plasma cells, which secrete immunoglobins.
-T: express CD4 on surface (helper cells); can be killer cells, permit the transformation of B cells into plasma cells

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9
Q

What is the nucleus of Neutrophils?

A

Multi lobed

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10
Q

What is the nucleus of Eosinophils?

A

Bi lobed

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11
Q

What is the nucleus of Basophils?

A

Bi or Tri lobed

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12
Q

What is the nucleus of Monocytes?

A

Kidney shaped

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13
Q

What is the nucleus of Lymphocytes?

A

Deep staining

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14
Q

What is the structure of Erythrocytes?

A

Biconcave disc
4 globin chains (2alpha & 2beta)
Each molecule carries a haem

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15
Q

What is the function of Erythrocytes?

A

Carries O2 to tissues and CO2 to the lungs

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16
Q

What is the structure of Reticular cells?

A

Synthesise reticular fibres and surround them with cytoplasm

17
Q

What is the function of Reticular cells?

A

Direct the T and B lymphocytes to specific regions with the lymphatic tissues

18
Q

What is the structure of Platelet cells?

A

Small round blue particles
Produced by megakaryocytes in bone marrow
Cytoplasm contains alpha and dense granules
alpha contains fibrinogen and Von Willebrand’s factor. Dense contains ADP and Ca2+

19
Q

What is the function of Platelets?

A

Clotting cascade

Adhere to damaged cells walls and aggregate together.

20
Q

How does RBC structure allow them to achieve their functions?

A

Biconcave, flexible disk (diameter 8 microm) facilitates passage that has a minimum diameter of 3.5microm.
4 globin chains, each has haem that can bind 1 molecule of O2
120 day lifespan

21
Q

Up to the liver, what is Haem catabolis?

A

Haemoglobin –> Haem –> Billirubin

22
Q

From the liver, where can billirubin go to exit the body?

A

Kidneys (Urobilinogen excreted)

Gall bladder, Intestines (Stercoblin excreted)

TOB II (15 decks)

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