Skeletal muscle 3; Physiology Flashcards

1
Q

What is isometric contraction?

A

No external shortening.

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2
Q

What is isotonic contraction?

A
  • Contraction with movement
  • Mismatch between tension generated by muscles and load.
  • Isotonic can be; Eccentric or concentric
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3
Q

What is isotonic concentric contraction?

A

Muscle length decreases against an opposing load.

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4
Q

What is isotonic eccentric contraction?

A

Muscle length increases as it resists a load

i.e climbing down mountains

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5
Q

What is associated with eccentric contraction?

A

DOMS are associated with eccentric contraction

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6
Q

What is the force length relationship?

A

Total force = passive and active

increased length increases the passive force and decreases active.

X axis = Length
Y axis = Force

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7
Q

What is the active force length relationship?

A

Theres an optimal resting length for the active force length relationship. Increased resting length or decreased lowers the maximal tension.

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8
Q

Whats the force velocity relationship?

A
  • As the load opposing the contraction is increased the velocity of shortening should decrease.
  • Constant load = constant velocity (isotonic)
  • Power depends on muscle velocity.
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9
Q

When is the contraction most efficient?

A
  • Contraction is most efficient at 1/3 max rate of shortening.
  • In humans efficiency ~20-25%
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10
Q

How rapid is ATP production in muscle cells?

A
  • No other cells can produce ATP as fast

- 20-100 fold difference between rest and activity.

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11
Q

What are the sources of ATP?

A
  • CP (10s)
  • Glycolysis (1min)
  • Aerobic (oxidative p/ph) (3min onwards) - fat or glycogen
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12
Q

What are some sources of muscular weakness?

A
  • Muscular fatigue
  • Muscular dystrophy
  • Sacropenia
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13
Q

What is muscle fatigue?

A

Defined as failure to maintain the required or expected power output leading to reduced muscle performance.

Aetiologies not yet clearly established.

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14
Q

Does lactic acid hinder performance?

A

Nope, its a very good thing.

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15
Q

What are potential sources of muscle fatigue?

A
  • Central fatigue

- Peripheral fatigue.

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16
Q

What is central fatigue?

A
  • Decreased activation from CNS

- Decreased number of motor units recruited.

17
Q

What is peripheral fatigue?

A

Affecting the cellular mechanisms that control force;

  • Smaller Ca transient
  • Reduced myofilament Ca sensitivity
  • Slower crossbridge cycling.

i.e metabolites , decreased energy

18
Q

What is duchennes muscular dystrophy?

A

Muscular weakness in all types caused by increased membrane permeability causing calcium ion leak.

19
Q

What is sarcopenia?

A

Age related muscle mass loss

20
Q

What are some sarcopenia related changes?

A

Increased % type 1 fibres.
Decrease fibre capillary ratio
Dennervation of fast twitch fibres
motor unit remodelling

Exercise and diet can slow progression