A/E

Question 1

A/E of nitrate

Answer 1

Excessive vasodilation
Headache
Postural hypotension
Tachycardia
Palpitations,weakness, Flushing
Overdose- methHb

TOLERANCE -
Due to NO generation
Depletion of sulfydryl radical in cell
Or generation of free radicals
Nitrate show cross tolerance

;. Intermittent tx - free interval of 8-10 hr

Question 2

A/E of CCB

Answer 2

Verapamil-
Constipation
Sinus bradycardia
Oedema
AV block

Nifedipine -
Hypotension
Palpitations
Reflex tachycardia
Fatigue,dizziness,sedation

Diltiazem-
Headache
Hypotension
Bradycardia
Oedema

Question 3

A/E of beta#

Answer 3

Since it decreases HR and FOC – ↓ CO – ↑ Lt. Ventricular EDV

bradycardia
Heart block
Bronchospasm c pt. c asthma

These are corrected by combining c nitrates

Question 4

A/E of k+ channel opener

Answer 4

Ulcer in mouth
Headache
Hypotension
Palpitations
Flushing,n,v