Abacavir Sulfate (Ziagen) Flashcards
Common adverse reactions associated with abacavir (ABC) include:
a. dream disorders
b. depression
c. anxiety
d. all of the above
e. b) and c) only
d. all of the above
Laboratory tests that should be done before starting ABC include all of the following except
a. lipid profile
b. renal function tests
c. viral resistance tests
d. liver function tests
e. HLA-B*5701 test
b. renal function tests
Which of the following can reduce ABC effectiveness if used concurrently?
a. Tipranavir
b. Alosetron
c. Alcohol
d. Methadone
e. None of the above
a. Tipranavir
During ABC therapy, when should HIV viral load be monitored?
a. Every 2 months in patients on stable therapy
b. 2–8 weeks after ABC initiation
c. After dose changes
d. a) and b)
e. a) and c)
f. b) and c)
f. b) 2-8 weeks after ABC initiation and c) After dose changes
Which of the following should be used cautiously with ABC?
a. Alosetron
b. Alcohol
c. Dapsone
d. a) and b)
e. a) and c)
f. b) and c)
a. Alosetron
Women and obese patients taking ABC might be at ↑ risk for lactic acidosis and severe hepatomegaly with steatosis.
a. True
b. False
a. True
What is the recommended ABC dosage for a 20 kg child with mild hepatic impairment?
a. 100 mg P.O. once daily
b. 160 mg P.O. once daily
c. 160 mg P.O. twice daily
d. 200 mg P.O. twice daily
e. None of the above
e. None of the above - no recommendations for pediatric patients with mild hepatic impairment
During ABC therapy, how frequently should CD4 cell count be performed?
a. Every 1–2 months
b. Every 2–3 months
c. Every 3–6 months
d. Once a year
c. Every 3-6 months
What is the recommended ABC dosing regimen in adults?
a. 200 mg P.O. three times daily
b. 300 mg P.O. twice daily
c. 600 mg P.O. once daily
d. a) or b)
e. a) or c)
f. b) or c)
f. b) 300 mg P.O. twice daily or c) 600 mg P.O. once daily
What is the interaction (if any) between ABC and alcohol?
a. Possible ↑ ABC clearance
b. Possible ↓ ABC clearance
c. Possible ↑ alcohol clearance
d. Possible ↓ alcohol clearance
e. None of the above
b. Possible ↓ ABC clearance
Angela tested negative for the HLA-B*5701 allele before she began ABC therapy. Today, she calls you and tells you that she has been vomiting and has a sore throat and a fever. How do you proceed?
a. Advise her to stop taking ABC
b. Advise her to go to the ED
c. Advise her to see her doctor within the next 24 hours
d. a) and b)
e. a) and c)
d. a) Advise her to stop taking ABC and b) Advise her to go to the ED
ABC can impair the effectiveness of which of the following?
a. Stavudine
b. Methadone
c. Ribavirin
d. All of the above
e. None of the above
d. All of the above = Stavudine, Methadone, Ribavirin
ABC is contraindicated in patients positive for HLA-B*5701.
a. True
b. False
a. True
ABC should be used cautiously in patients with
a. moderate hepatic impairment
b. residual opportunistic infections
c. immune reconstitution syndrome
d. all of the above
e. a) and c) only
b. residual opportunistic infections
ABC is classified as pregnancy category
a. B
b. C
c. D
d. X
b. C
