Aberrant Immune Response

Question 1

What is type I hypersensitivity?

Answer 1

The culprits for this hypersensitivity are IgE and Mast Cells.

Question 2

What is type II hypersensitivity?

Answer 2

Antibody-mediated immune reaction in which antibodies (IgG or IgM) are directed against cellular or extracellular matrix antigens, resulting in cellular destruction, functional loss, or tissue damage.

Question 3

What is type III hypersensitivity?

Answer 3

A type of immune response in which antigen-antibody complexes accumulate in the tissues and cause inflammation and tissue damage

Question 4

What is type IV hypersensitivity?

Answer 4

occur in response to contact with certain allergens resulting in what is called contact dermatitis or in response to some diagnostic procedures as in the tuberculin skin test.

Question 5

What is Goodpasture’s syndome?

Answer 5

A disease that affects lungs and kidneys.
- It causes Inflammation and bleeding in the lungs, and hematuria (blood in urine).
- Autoimmune antibodies attack Collagen IV in lungs.

Question 6

What is Marfan syndrome?

Answer 6

Affects connective tissues of skin, bone, blood vessels and many other organs and tissues.
- Caused by mutations in the fibrillin gene.
- Causes heart defects & vision problems.

Question 7

What is Alport Syndome?

Answer 7

• The basement membrane in the glomerulus of the kidney forms a part of the selectively permeable glomerular filtration barrier
• Mutations in collagen IV genes
• Dysfunctional Collagen IV → dysfunctional BM → blood and protein in the urine

Question 8

What is Ehlers-Danlos Syndrome?

Answer 8

• Affects connective tissues of skin, bone, blood vessels etc.
• Mutations in Collagen genes → hypermobility due to very stretchy skin.