ABG Flashcards
(46 cards)
pH is inversely proportional to ______.
H+
If pH is < 7.35 then it is _____.
acidic
If pH is >7.45 then it is _____.
alkalotic
Why does the blood pH matter?
pH and temperature affect biochemical reactions
An acidotic state can lead to what 3 negative effects?
- decreased efficacy of medications
- decrease in catecholamine response
- decrease in cardiac contractility
An alkalotic state can lead to what 3 negative effects?
- interferes with muscular contractions
- interferes with neurological functioning
- interferes with tissue oxygenation
What is the definition of a buffer?
Chemical that binds excessive H+ (or OH-) without significant pH shift
What is the most important plasma buffering system?
carbonic acid-bicarbonate system
A buffer pair consists of what 2 things?
a weak acid + conjugate base
What is the carbonic acid-bicarbonate equation?
H2O + CO2 H2CO3 H + HCO3
In the body what is the “hero” and “villain” of the acid-base balance?
- hero = bicarbonate
- villain = acid (H+)
What does the respiratory buffer response do?
CO2 is eliminated or retained via respiration
The more CO2 in the body the _______ the pH.
lower
The less CO2 in the body the _______ the pH.
higher
What organ is responsible for the renal buffer (metabolic) response?
kidneys
The renal metabolic response consists of what 2 things?
- kidneys excrete or retain bicarbonate
- kidneys excrete or retain H+
The more HCO3-, the _____ the pH.
higher
The less HCO3-, the _____ the pH.
lower
How does the lungs compensate for an increase in carbonic acid (pH lowering)?
Eliminates more CO2 by increasing respiration
How does the lungs compensate for a decrease in carbonic acid (pH increasing)?
Retains more CO2 by decreasing respiration
Which of the compensation methods (respiratory/metabolic) is quick and begins in minutes?
respiratory
How does the kidneys compensate for an increase in carbonic acid (pH lowering)?
Retains more HCO3
How does the kidneys compensate for a decrease in carbonic acid (pH increasing)?
Excretes more HCO3
What equation describes the derivation of pH as a measure of acidity?
Henderson-Hasselbach Equation