Abnormal behaviour Flashcards

(247 cards)

1
Q

Provide an overview on how mental illness was diagnosed and treated until now

A

• Mental illness was defined as madness or insanity
o Defined by gross distortion of external reality (hallucinations, delusions), or disorganisation of speech, affect, behaviour (confusion, memory loss, etc.)
o Similar to today’s diagnoses of psychosis, schizophrenia and dementia
• 18-19th centuries:
o Small number of patients treated in mental asylums (mental hospitals) by mad doctors or alienists
 Anyone interested/able to treat disorders: no qualifications required
o Anxiety, sadness, angst, etc. not ‘mental illness’
o Priests, friends, family assisted with problems of living
• Today, 400+ categories of mental disorder
• Definitions defined by social influences and norms

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2
Q

What are the two handbooks currently being used today, who were they published by and where are they mainly used?

A

o Diagnostic and statistical manual of mental disorders (DSM-5)
 Used in Australia and the US and published by APA
o International Classification of Diseases (ICD-10; ICD-11 in preview in 2022)
 Published by world health organisation but used in Australia

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3
Q

How many Australians are identified to have a mild, moderate or severe mental disorder?

A

4 million

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4
Q

What are the DSM and ICD and which professionals do they help?

A

o Two publications contain descriptions of various mental disorders and reflect the consensus of mental health professions regarding the definition and classification of mental disorders at the time of their publication
o DSM and ICD describe symptoms clusters  syndromes
 E.g. Schizophrenia, major depression…
• Treated by psychiatrist, psychologists, clinical psychologists, social workers, counsellors

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5
Q

What is the DSM’s definition of a mental illness?

A

o A mental disorder is a syndrome characterized by clinically significant disturbance in an individual’s cognition, emotion regulation, or behaviour that reflects a dysfunction in the psychological, biological or developmental processes underlying mental functioning. Mental disorders are usually associated with significant stress or disability in social, occupational or other important activities

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6
Q

Is it easy to define mental disorder? Why/why not?

A

• But no definition of mental disorders is enough- hard to define as influenced by societal norms

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7
Q

What are the advantages of mental disorder diagnoses?

A
  • Improve communication between health professionals (clinicians and researchers)
  • May improve communication and understanding of mental illness in the community
  • May reduce social stigma
  • Helpful to the client-> normalising and validating
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8
Q

What are the disadvantages of mental disorder diagnoses?

A

o Mental disorders are being treated like physical afflictions, but mental illnesses are simply theoretical constructs and are not independent of changing social values
o Used as explanations rather than descriptive terms
o May sometimes be harmful to people- feel as if they have been stigmatised

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9
Q

Are ICD and DSM the same? Describe differences if there are any

A

No-• ICD and the DSM are comparable but not identical
o Problem as diagnosed differently according to where you live
 English speaking countries- DSM
 Europe- ICD
o Mixed Anxiety-Depression (ICD), Generalised Anxiety Disorder (DSM), Binge Eating Disorder (DSM)

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10
Q

What are examples of changes through the DSM editions?

A

 Homosexuality removed from the DSM in 1973
 Generalised anxiety disorder first introduced in DSM-III-R (1987)
 Binge eating disorder first included in DSM-5 (2013)
 Asperger’s disorder symptoms reclassified and included in the section of Autism Spectrum Disorders in DSM-5 (2013)
 Gaming disorder added to the section on Addictive disorders in ICD-11 (2018)

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11
Q

Describe the main principles of DSM-I and DSM-II

A

DSM-I (1952) and DSM-II (1986)
• Strongly influenced by psychoanalytic theory
• Very concerned with causation
• Had two main sections:
o Biological causation diseases
o Psychological reactions to individual’s environment or internal processes
• Thought patient’s defense mechanisms were causes

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12
Q

What were the limitations of DSM-I and DSM-II?

A

o psychoanalysis is not proven and can’t be measured
o limited reliability
o Not a lot of detail on required length of disorder or required severity: line between normal and abnormal blurred

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13
Q

Which DSM’s were approached via the Kraepelin approach and what did they do?

A
  • DSM-III (1980)
  • DSM-III-R (1987)
  • DSM-IV (1994)
  • DSM-IV-TR (2000)
  • Focus on observable symptoms
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14
Q

Talk about the DSM-V and its improvements

A

• DSM-V (2013)
o Reflects the medical/biological model
o No theoretical assumptions about causation
o Description of symptoms:
 Patient report, direct observation, measurement
 No assumptions about unconscious processes
 Clear, explicit criteria and decision rules
• Improved reliability, but validity questionable
 Focus on symptoms
o Clear guidelines for differential diagnosis
o Interrater reliability increased

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15
Q

What are problems of the DSM-V?

A

o Problems include comorbidity, diagnostic instability and lack of treatment specificity
 Comorbidity questions the validity of separate, independent diagnostic categories

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16
Q

What is the difference between DSM-I and II, vs all the DSM’s that came after?

A

DSM-III, DSM-III-R, DSM-IV, DSM-IV-TR and DSM-5

Specific diagnostic criteria for each category
No explicit assumptions about causation
Polythetic format: a set of optional diagnostic criteria is provided: only a subset is needed for diagnosis

DSM-I and DSM-II
Unspeciffic, general descriptions of categories
Assuming causation from a psychoanalytic viewpoint
Monothetic format: general description of criteria without specifying which ones are necessary and which ones are optional

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17
Q

Who were the Rorschach inkblot tests developed by and what were they used for? Was there a lot of evidence suggesting they worked?

A

 Rorschach in 1921 published psychodiagnostik
• Reflects psychoanalysis, psychodynamic principles
• Originally developed to diagnose schizophrenia
o Small amount of evidence that it works for schizophrenia
• Later further developed to become a personality test used in clinical settings
• Both reliability and validity highly disputed
• Rarely used in Australia
• Helped therapist to get to unconscious process, but not much evidence for it

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18
Q

What occurs in an unstructured clinical interview and why?

A

o For clinical assessment
o Forming a therapist-client therapeutic alliance
 Client needs to trust you and feel you are open minded
o Diagnostic questioning:
 To guide further assessment
 To formulate diagnosis (DSM-5)
 For treatment planning/delivery
o Presenting problem current symptoms
 Try to figure out problem according to their symptoms
o Current living circumstances, relevant history
 Dependent on the clinician’s theoretical orientation
• Behavioural vs psychoanalyst approach
o Case formulation

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19
Q

What is involved in case formulation?

A

 What are the factors that predispose this individual to the development of this or these presenting problems?
 What are the factors that act as precipitants in the presenting problems(s)?
 What are the factors that serve to maintain the presenting problem(s)?
 What are the factors that serve to predict the outcome?
 Form hypothesis about what maintains problems, and what will promote and hinder change

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20
Q

What should happen at the end of a psychologist’s first session?

A

 Explain and summarise this session

 Provide direction to future plans of implementation

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21
Q

What is involved in a semi-structured assessment?

A

o Structured clinical interview for DSM-5
o Interview administered by trained clinicians
o Tailored: client’s response determines the next question
o Presence of symptoms+ severity  diagnosis
o Highly reliable, valid assessment of DSM-based diagnosis
o Only as valid as the DSM is

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22
Q

What is involved in structured clinical interviews? What are they used for?

A

o Treatment evaluation studies, Research studies, Epidemiology
o Composited International Diagnostic Interview -CIDI (WHO)
 Can be administered by not clinically trained interviews
• E.g. National Survey of Mental Health and Wellbeing Australian Bureau of Statistics (ABS)

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23
Q

What are self-report diagnostic questionnaires used for?

A

o Often used to screen for possible diagnosable disorders
o Include DSM diagnostic criteria but less structured and more narrow than structured interviews
 E.g. AUDIT (Alcohol Use Disorder Identification Test) and EDDS (Eating Disorders Diagnostic Scale)
o Based on scores
o Often used for:
 Dimensional assessment of symptoms, emotions, behaviours relevant to mental health
• Varying degrees of severity to a mental disorder
• Bounday between normality and abnormality is indistinct: moves from the “you have it or you don’t” approach for one where there are varying degrees of having it or not.

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24
Q

Do all self-report questionaires reflect DSM-based diagnostic criteria? What are examples of this?

A

 Some reflect DSM-based diagnostic criteria, others do not
• E.g. Narcissistic Personality Inventory (NPI)
o Developed on the basis of DSM-IIII diagnostic criteria for NPD
• Depression Anxiety Stress Scales (DASS)
o Developed independently of DSM criteria
o Focuses on emotion

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25
What are disadvantages of self-report questionnaires?
o Disadvantages are that they are transparent and easy to cheat on, and impractical for someone who can’t express their symptoms
26
What are other types of reports and observations?
o Spence Children’s anxiety scale  Child report  Parent report o Direct observation of behaviour  ABC method: antecedents, behaviour, consequences  Checklists, coding schemes o Psychological measurements  Brain scans, heart rate, skin conductance, etc.  None of these are diagnostic: used in research for causes and consequences
27
What is the DSM-5 criteria for a depressive episode?
• At least 5+ symptoms during a 2 week period (NEED symptom 1 or symptom 2) 1. Depressed mood most the day, nearly every day 2. Markedly diminished pleasure/interest in activities 3. Significant weight loss or weight gain 4. Insomnia or hypersomnia nearly every day 5. Psychomotor agitation or retardation 6. Fatigue or loss of energy nearly every day 7. Feelings of worthlessness and excessive guilt nearly every day 8. Diminished ability to concentrate nearly every day 9. Recurrent thoughts of death, suicide, suicide attempts • Clinically significant distress or impairment • Not attributed to substance use or other medical condition • Affective symptoms: depressed mood, anhedonia • Cognitive symptoms: indecisiveness, lack of concentration • Somatic symptoms: Fatigue, sleep or appetite change
28
What is defined as a major depressive disorder?
* Under DSM-5, is classed under depressive disorders * Single or recurrent depressive episode, NOT accounted for by other disorders (e.g. schizophrenia) * Recurrent episodes are common
29
What is the criteria A for a manic episode? (DSM-5)
o Criteria A:  At least one week of: • Abnormally and persistently elevated, expansive or irritable mood and • Increased goal directed activity/energy, present nearly daily
30
What is criteria B for a manic episode?
 At least 3 or more present to a significant degree and noticeable change from usual behaviour • Inflated self-esteem or grandiosity • Decreased need for sleep • Rapid or pressured speech • Flight of ideas or racing thoughts • Distractibility • Increase in goal-directed activity or psychomotor agitation • Excessive involvement in activities that have a high potential for negative consequences
31
What are usual manic episode patterns?
o Manic episodes typically evolve over several weeks from heightened wellbeing to euphoria o Episodes move quickly from an elated mood to an irritable mood or can fluctuate between elation and irritability o Irritable type manic episode (more common despite popular beliefs about mania) with the elevated/expansive type manic episode
32
What is criteria C of a manic episode?
 Sufficiently severe to cause marked impairment in occupational functioning or in usual social activities  OR to necessitate hospitalisation to prevent harm to self or others  OR there are psychotic features (e.g. delusions or hallucinations)
33
What is criteria D of a manic episode?
 The symptoms are not due to the direct physiological effects of a substance (e.g. drug or medication) or a general medical condition (e.g. hypothyroidism)
34
What is a noteworthy change in DSM-5 regarding manic episodes?
the fact that increased activity or energy was now required (along with mood changes) to meet the criteria for a manic or hypomanic episode
35
What is the DSM-5 criteria for a hypermanic episode?
• Bipolar II: Hypomanic episode (DSM-5) o At least 4 days of:  Abnormally and persistently elevated, expansive or irritable mood, and  Increased goal directed activity/energy, present nearly daily o 3 or more:  Inflated self-esteem or grandiosity  Decreased need for sleep • Can feel quite rested after small amounts of sleep  More talkative/pressured speech  Flight of ideas; racing thoughts  Distractibility  Increased goal directed activity or psychomotor agitation  Excessive involvement in pleasurable activities which have a potential for negative consequences o Change that is uncharacteristic of the individual o Disturbance and changes are observable by others o Not severe enough to cause marked impairment, or hospitalisation and no psychotic features- people can mostly go about normal activities o Not due to substances/medical condition
36
What is the difference between bipolar I and bipolar II?
Bipolar I: Major depressive episode- can be present but not necessary for diagnosis Manic episode- YES Hypomanic episode- Can be present but not necessary for diagnosis Bipolar II: Major depressive episode- YES Manic episode- No: not seen in this disorder Hypomanic episode: YES
37
Describe DSM-5's description of cyclothymic disorder
o Chronic, less severe form of bipolar disorder o Numerous cycles of hypomania symptoms and depression symptoms that are not severe enough to meet criteria for a manic or major depressive episode o Symptoms for at least 2 years but no more than 2 months without symptoms o Symptoms cause distress or impairment in functioning
38
What are diagnostic issues that bipolar disorders face and why are these issues?
• Bipolar disorders are often: o Undetected/undiagnosed o Over-diagnosed (that is borderline personality disorder) or underdiagnosed  Overdiagnosis could mean inappropriate and excessive use of mood-stabilising medications, as well as insufficient attention paid to the psychological aspects of unipolar depression or the personality disorder o Misdiagnosed as schizophrenia (particularly in men) or unipolar depression(particularly in women)  Bipolar people seem to go to therapist when feeling depressive, not manic  Problem is that they may not respond to anti-depressants given: need mood stability medicine instead  Existence of shared features between these disorders can make their diagnosis challenging o Lack of diagnosis in those with anxiety disorders and substance use disorder • Diagnostic problems have implications for pharmalogical and psychological interventions
39
What is the 12 month prevalence rate in Australia for bipolar I and II?
Near 1%
40
What is the lifetime prevalence of bipolar I and II?
1.3%
41
Are there gender differences for BPI and BPII diagnosis?
• No gender differences for BPI, BPII more common in women
42
What is the onset of bipolar disorder? Specify:
• Onset: peak at 15-25 years (for both genders) o No clear definition as to what the onset is o Tends to be a poorer outcome if the onset occurs in childhood or adolescence o 25% of individuals experience onset by age 17, and median age is 25 o Rare for onset to occur after 30
43
What is the delay to seeking treatment for bipolar disorder?
10-20 years
44
How many individuals with bipolar disorder experience multiple episodes of mood disturbance during their lifetime? How does this occur?
90% | -Generally occurs over weeks or months rather than a matter of days
45
When untreated, how many episodes will BDI patients experience in their lifetime?
o Untreated: 8-10 lifetime episodes of mania and depression
46
How are relapse rates with treatment in bipolar patients and what is the effect of lithium on treatment?
o With treatment: 40% relapsing within 1 year; 73% within 5- years  Treatment minimises impact and episode number  Lithium fully protects on 25-50 % patients against further episodes and there are often problems with gaining compliance from patients in taking their medication
47
How much time do BDI patients stay depressed/ manic or hypomanic?
o Bipolar I: 32% of the time depressed; 9% manic/hypomanic
48
How much time do BDII patients stay depressed/hypomanic?
o Bipolar II: 50% of time depressed; 1% hypomanic
49
How does rapid cycling work in Bipolar disorder patients?
o Rapid cycling: 5-15% of sufferers have 4+ episodes (mania, hypomania or depression) within a year  Includes those who recover between episodes and those who switch continually from one polarity to the other
50
What can bipolar disorder be comorbid with?
• High rates of co-morbidity: o 50% anxiety disorders (panic, GAD, social phobia)  Anxiety symptoms precede, occur during or follow (hypo)manic symptoms at different rates depending on the type of comorbid disorder  Clear pattern of social phobia preceding (hypo)mania  Anxiety disorders are often treated with antidepressants, which suggests that antidepressants may at times be triggering manic or hypomanic symptoms o 39% substance misuse (coping or self-medication or to enhance the high)
51
How many bipolar disorder sufferers attempt/complete suicide? Is there a discrepancy between BDI and BDII?
• At least 25% will attempt suicide; 10-20% will complete suicide o Higher rates among individuals with bipolar II disorder compared to those with bipolar I disorder, most likely due to the more frequent episodes of depression in the former compared to the latter
52
What are the genetic risks of bipolar disorder?
 Lifetime risk for family members of BP patients: 10% (versus 1% in the general population) 1. Bipolar runs in families- 10x higher risk for someone with a bipolar parent to have bipolar disorder  Twin studies: BP heritability rate of around 80-85%
53
What is the biological explanation for bipolar disorder?
 BP is a neurobiological disorder, largely due to a malfunction of three “reward system” neurotransmitters: serotonin, dopamine and noradrenaline 1. But how much causes and how much is a result of?  BP may lie dormant and be either activated spontaneously or be triggered by (e.g. environmental and life) stressors
54
Is there an association between bipolar disorder and stressful life events?
 An association between stressful life events and both manic and depressive episodes 1. Manic episodes likely preceded by: o Disruption to routines and sleep-wake cycles o Excessive focus on goal attainment 2. Depressive episodes likely preceded by: o Low social support o Low self-esteem  Individuals with bipolar disorder who experience high levels of stress are four and a half times more likely to have a mood relapse than individuals with low levels of life stress
55
What are the psychological factors that can increase vulnerability to bipolar disorder?
o A negative cognitive style enhances vulnerability to manic and depressive episodes when paired with stressful life events o Mania may be a defence to counter the negative thoughts and feelings relating to an underlying negative self-esteem o Excessive pursuits of goals may disrupt routines and hence trigger manic or hypomanic episodes in the excessive pursuit of goals o Temperament (ensuring personality traits and characteristics) factors:  Perfectionism  Sociotropy 1. The need to be socially approved  More prevalent in individuals with bipolar disorder than those with depressive disorder
56
What is the goal dysregulation model?
 Goal dysregulation model- theory that manic episodes may be triggered by dysregulated goal pursuit, which entails the person being excessively involved in the pursuit of goals
57
Describe the diathesis-stress model
``` o Diathesis-Stress model  Originally developed for schizophrenia  Holds that psychological disorders result from interactions between underlying vulnerabilities and stressful life events 1. Life stressors: o Causing poor social routines and/or sleep deprivation 2. Biological vulnerability o That is circadian rhythm instability which can affect bipolar people 3. Prodromal stage o Early symptoms of mood disturbance 4. Poor coping strategies 5. Episode o Manic o Hypomanic o Depressive 6. Stigma and Relationship problems o Stigma by others or oneself 7. Cycles once again ```
58
What does bipolar disorder treatment depend on?
• Depends on: o Illness stage (acute, maintenance) o Predominant polarity (depressive, hypo/manic)
59
What is the best treatment for bipolar disorder?
• Most treatment evidence based on Bipolar I: extrapolated to BPII and others • Best treatment= Pharmacological + (adjunct) Psychological interventions o Found lithium was a good treatment for mania (Cade)  50% of clients respond o Carbamazepine also a good treatment for people who don’t respond to lithium o Lithium and carbamazepine good combination
60
Talk about bipolar disorder and creativity
o Associated with creative groups  17% of a sample of British poets received treatment for manic episodes  Enhanced creativity likely linked to manic/hypomanic states and accompanying suprasensory changes o Famous people with bipolar disorder:  Artists: Gauguin; Van Gough; Pollack  Writers: Lord Byron; Virginia Woolf; Hemingway  Composers: Handel; Schumann • Many people with bipolar disorder identify as creative
61
What does psychosis refer to?
• Refers to loss of contact with external reality characterised by: o Impaired perceptions and thought processes • First type of mental illness ‘identified’ in olden days
62
What is an overview definition of schizophrenia
• Fragmentation of thoughts • Splitting of thoughts from emotions o Disconnect between facial expressions/emotions and thought/speech • Withdrawal from reality
63
What is criteria A for schizophrenia?
A. Characteristic symptoms: a. Lasts at least 6 months, with at least one month of two (or more) of following and at least one must be (i) ,(ii), or (iii) below: i. Delusions ii. Hallucinations iii. Disorganised speech (formal thought disorder) iv. Grossly disorganized or catatonic behaviour v. Negative symptoms
64
What is criteria B for schizophrenia?
B. Clinically significant impact to social/occupational functioning (functioning is below that prior to onset of the disorder)
65
What is criteria C for schizophrenia?
C. Continuous signs of disturbance are present for at least 6 months a. May include a gradual deterioration in functioning b. Must include at least one-month of psychotic symptoms
66
What is criteria D for schizophrenia?
D. Not better accounted for by other diagnosis
67
Compare positive vs negative symptoms
Positive symptoms -Presence of problematic behaviours Negative symptoms -Absence of healthy behaviours
68
What are positive symptoms of schizophrenia
- Hallucinations - Delusions - Formal thought disorder - Behavioural/motor disturbances - Lack of insight on what's happening to them (not really a positive symptom but pretty important nonetheless)
69
What are the negative symptoms of schizophrenia?
Affective Flattening (a dampening down in the expression of emotion)- - --Social withdrawal - --Anhedonia (Not experiencing pleasure in their life) - --Emotional blunting - --Confusion Avolition (the loss of drive or motivation)- - --Amotivation - --Apathy - --Self-neglect Alogia (a lack of unprompted speech)- - --Poverty of speech - --Poverty of content
70
Do positive or negative symptoms suggest poorer response to treatment?
Negative symptoms
71
What can be seen in schizophrenia from cross-cultural studies?
• Cross-cultural studies: similar forms across societies but cultural differences in content and interpretation o Hearing voices is the same but content different o African/Indian studies- voices are positive and cause less distress o America and Western countries- voices are more hostile or aggressive
72
What is the lifetime prevalence of schizophrenia?
1-2%
73
What is the male: female ratio of schizophrenia diagnosis?
3:2
74
What is the typical age of onset for schizophrenia?
• Typical onset in late adolescence and early adulthood (tends to be later for women) o 17-30 years old for males o 20-40 years old for females
75
What is onset of schizophrenia usually preceded/ coinciding with?
* Onset typically preceded by a gradual deterioration in functioning followed by appearance of more acute symptoms * Onset coincides with an often stressful time of life, further complicated by impact of schizophrenia
76
Is early onset and early treatment of schizophrenia associated with better outcomes
* Early onset associated with poorer outcomes | * Early treatment associated with better outcomes (yet delay in treatment common)
77
Is schizophrenia the same in presentation and course for everyone?
• Highly variable in presentation and course | o One or more episodes, with periods of normal (or near normal) functioning between episodes
78
Can you fully recover from schizophrenia?
• Chronic condition without full recovery | o Most remain chronically unwell with a deteriorating course
79
Describe the future work and social life of those diagnosed with schizophrenia
o 50% unable to work, <25% employed | o Social isolation, homelessness, low income and poor health
80
How many schizophrenia patients attempt/complete suicide?
o 30% of patients attempt suicide; 5-10% complete suicide
81
What are the downsides of assigning medication to schizophrenics?
o Can function with medication but medication has side effects, or patients don’t feel like they need the medication anymore, or they think it will poison them, so don’t take medication and it worsens
82
Describe the 4 stages of schizophrenia
• Premorbid phase- o Cognitive motor or social deficits • Prodromal phase- o Brief/attenuated positive symptoms and/or functional decline o Median time is 2 years before psychotic symptoms o Typically late adolescence and early adulthood • Psychotic/acute phase- o Florid positive symptoms o Usually one year delay between this and looking for treatment • Recovery phase: o Negative symptoms, cognitive/ social deficits, functional decline if treatment fails o Risk of further episodes of psychosis remains high during the first 2-5 years after treatment is commenced  In approximately 80-90% of these cases, relapse will occur during this period o Relapse can often occur by ditching medication, abusing substances or coming back to overly protective/criticizing families
83
What are the schizophrenia prognostic factors that will indicate good response to treatment
``` Good premorbid functioning Acute onset Later age of onset (females) Precipitating event (e.g. drug induced psychosis) Low substance use Brief active phase Absence of structural brain abnormalities No family history of schizophrenia ```
84
What are the schizophrenia prognostic factors that will indicate poor response to treatment
``` Poor premorbid functioning Slow insidious onset Prominent negative symptoms Long duration of untreated psychosis Slower or less complete recovery Lower socioeconomic class Migrant status Poor social support network ```
85
What are comorbid disorders to schizophrenia?
o Depression o Anxiety and trauma-related problems o Substance misuse
86
Is there a genetic risk to schizophrenia? If so, what is the evidence for it?
 Degree of risk related to a degree of heritability  The risk of developing schizophrenia increases as the degree of genetic relatedness with an affected individual increases • Determine susceptibility  disorder triggered by other factors o 7% siblings o 9% for children of 1 affected parent o 46% for children with 2 affected parents  Twin studies concordance rates: • 12% for DZ twins • 44% for MZ twins  Adoption studies: • 19% for children of biological parents with schizophrenia • 10% for children of biological parents with no schizophrenia
87
What is the dopamine hypothesis for schizophrenia
Overproduction or oversensitivity of dopamine receptors (especially D-2 receptors)
88
What is the evidence for the dopamine hypothesis?
• Treatment for Parkinson’s disorder: o L-DOPA (increases dopamine concentration) can induce psychotic symptoms • Amphetamine (against dopamine) psychosis: o Abnormally large responses to low amphetamine doses suggests over-sensitivity rather than excessive dopamine level o Amphetamines, which cause the release of dopamine, can produce symptoms of schizophrenia • Response to anti-dopaminergic medication (e.g. chlorpromazine and haloperidol which block dopamine receptors, or new clozapine drug which blocks 5-HT receptors) o Effective in 60% with more impact on positive symptoms
89
What biological aspects are associated with positive schizophrenia symptoms (Type 1 schizophrenia)?
Dopamine activity, specifically increased dopamine levels (but there are problems with this theory- increased dopamine levels not found in patient's brains) and with increased sensitivity to dopamine (more probable) - ---Still issues with this theory - Responds well to treament and medication - Fluctuating course with periods of remission
90
What biological aspects are associated with negative schizophrenia symptoms (type 2 schizophrenia)?
Brain degeneration - Responds poorly to drugs - Chronic course with little improvement
91
What is the neuroanatomical make-up of a schizophrenic person?
 Most consistent finding: • Enlarged ventricles in schizophrenia (post-mortem; CT scans: MRI studies) o Relative size more than twice that of normal controls • Most likely cause is loss of brain tissue; scans indicate chronic schizophrenia is associated with brain abnormalities  Loss of brain tissue tissue in pre-frontal cortex • Linked to negative symptoms: damage to executive functioning/cognitive abilities  Non-genetic structural brain abnormalities appear to: • Predate onset of psychosis • Worsen with progressive illness • Deficit in brain matter incre ases with number of episodes • Schizophrenia as a degenerative brain disorder • Structural changes in the hippocampus appear to predate the onset of psychosis (smaller hippocampus in those without high risk) • Psychosis related to disturbances in the Hypothalamic-pituitary-adrenal axis o Environmental factors affect the HPA axis o Genes associated with the risk of schizophrenia contribute to dysfunctional HPA axis activity o Important biological system in the physiological response to stress
92
What are the environmental/psychosocial factors that can encourage schizophrenic development at birth?
```  Antenatal complications  Viral infections  Nutrition  Urban birth  Seasonal variation --Winter/early spring birth more likely to have schizophrenia because of decreased levels of vitamin D  Increased paternal age ```
93
What are the environmental/psychosocial factors that can encourage schizophrenic development at early adolescence
```  Child abuse/trauma  Social stresses  Urban upbringing  Migration  Discrimination ```
94
What are the environmental/psychosocial factors that can encourage schizophrenic development at late adolescence
 Dysfunctional cognitions  Amphetamine  Cannabis
95
What are the environmental/psychosocial factors that can encourage schizophrenic development further in life?
 Idiopathic stress  Social/educational/work stresses  Interpretation of culturally unacceptable intrusive thoughts (e.g. someone is controlling my thoughts vs I must be tired) • Result of faulty knowledge about the self and others resultant from bad life experiences • Encouragement of behaviours that encourage other intrusive thoughts
96
What can happen after onset of psychosis?
 Relapse |  Substance abuse
97
Describe the effectiveness and type of medication used on on schizophrenic patients
o Primary intervention o 60% of clients with positive symptoms respond o 10-20% do not show symptom improvement in response to medication o Relapse rates high with 40% relapsing within one year o Medication non-compliance common, given common side effects o Antipsychotic medication o Mood stabilisers and antidepressants o Benzodiazepines to assist in sleep and reduce anxiety
98
Describe the psychological interventions used on schizophrenic patients
o Need to be tailored to the stage of illness o Important to work from the patient perspective o Designed to target specific deficits or therapy goals:  Social skills training for interpersonal deficits  Group based interventions  Medication compliance  Stress management  Managing and reducing residual delusions/hallucinations • Systematic review and meta-analysis: o 53 RCTs evaluation 7 psychological interventions  N=4,068 participants, moderately ill at baseline, receiving antipsychotics + psych therapy  CBT reduced positive symptoms more than • Inactive control • Treatment as usual • Supportive therapy  CBT reduces reslapse  CBT good for reducing the transition to psychosis for individuals at high risk of developing a first episode of psychosis
99
What do we need to do to treat schizophrenics more effectively?
• Need to have more facilities for mental health and make CBT and other forms of treatment more available, as well as reduce stigma about psychosis
100
Is schizophrenia polygenetic or accounted for by a single gene?
Polygenetic
101
What is a drug/substance?
• A drug/substance is any substance that exerts an effect on body or mind (prescription, legal and illicit)
102
What can the effects of drugs/substances be?
``` • Effect may be: o Neurophysiological  Respiratory, tachycardia, dilatation o Behavioural  Sedated, aggressive o Emotional  Excitement, confidence o Cognitive  Impaired judgement and memory ```
103
What are different drug classifications and some examples of these?
o Depressant (downers)  Alcohol, barbiturates, inhalants, benzodiazepines, sedatives o Stimulants (uppers)  Cocaine, amphetamines, caffeine, nicotine, MDA (ecstasy) o Hallucinogen (altered perceptions)  Mescaline, LSD, psilocybin o Opioid/narcotics (analgesia)  Morphine, heroine, codeine, methadone o Cannabinoids  Marijuana, hash, ganja o Tobacco, steroids, volatile solvents, prescription drugs
104
What are different ways to administer drugs, and their relative speed?
• Intravenous o Rapid and controlled pathway o Fastest activity • Inhalation o Substance goes through lungs, blood and then brain • Oral o Substance goes through stomach, where enzymes break it down: takes longer
105
What are the social perspectives on each drug? Is each drug inherently dangerous?
• Drugs can be viewed as neutral substances, but are restricted/banned due to their impacts (such as their harmful and addictive effects, which were discovered over time) • Value judgement (depending on use and effects) determine if they become illicit vs not illicit o Alcohol is socially acceptable in moderation  Although harmful, its history would make it hard to ban o Cigarettes are legal despite having no beneficial effects o Prescription drugs are accepted but can be abused o Illicit drugs- have varied social/legal condemnation
106
Is recreational use of marijuana legal in Australia?
No
107
What is physiological dependence?
associated with physical symptoms of tolerance and withdrawal on cessation (need)
108
What is psychological dependence?
cravings/desire leading to repetitive (compulsive) use (want)
109
Describe substance disorders in DSM-IV vs DSM-V
``` o DSM-IV  Substance dependence  Substance abuse o DSM5  Substance-related and addictive disorder • Substance use disorders • Substance induced disorders  Non-substance-related behavioural addictions • Gambling ```
110
For substance related (and addictive disorders), what drugs does DSM5 cover diagnostic criteria for?
``` separate classes of drugs: o Alcohol o Caffeine (substance use disorder does not apply to caffeine) o Cannabis o Hallucinogens o Inhalants o Opioids o Sedatives, hypnotics or anxiolytics o Stimulants o Tobacco ```
111
What is the criteria to be diagnosed with substance related disorders?
o Tobacco • Criteria A for DSM-5 substance related disorders: Individual must have at least 2 of the following symptoms within a 12-month period, which have resulted in clinically significant distress or impairment, to be diagnosed with a substance use disorder o Larger amounts of the substance are consumed than the individual intended o There is a persistent desire, or unsuccessful attempts, to reduce substance use o A large amount of time is spent obtaining, using or recovering from the effects of the substance o The individual experiences a failure to fulfil major role expectations due to recurrent substance use o Ther eis continued substance use even though it results in social or interpersonal difficulties o Substance use interferes with the individual’s ability to engage in social or occupational activities, so that these activities are reduced or cease entirely o Substance use occurs in situations where it is physically hazardous o There is continued use of the substance even though the individual is aware of the problems caused by the substance o Tolerance is present, as evident by either:  A need for increased amounts of the substance in order to achieve the same effect  A markedly diminished effect for the same amount of the substance o Withdrawal is present, as evident by either  A range of characteristic physical and psychological symptoms that emerge after a cessation or reduction in substance use  Taking the substance (or a closely related substance) in order to alleviate these symptoms
112
What are comorbidities of substance use and what could be the cause of these?
o 60% of substance users have a co-morbid psychiatric disorder  Compared to general population: • Patients with mood/anxiety disorders twice as likely to suffer substance disorder • Patients with substance disorders twice as likely to suffer a mood/anxiety  This could be due to: • Overlapping genetic vulnerabilities • Overlapping environmental triggers • Involvement of similar brain regions • Interactive effect: drug/other disorders can increase vulnerability to the other
113
Describe the trend for drugs among 12+ years olds for past 30-day illicit drug use
• Among 12+ years old for past 30-day illicit drug use trends, cocaine and marijuana use are going up, but nonmedical use of psychotherapeutics, hallucinogens, binge alcohol use and illicit drugs is staying stable
114
When are people most likely to use substances?
• For substance use, peak substance use is between 20-30 years old, then it goes back down again (downward hyperbola trend)
115
What is the disease model of addiction
o Disease model of addiction- describes addiction as a medical disorder characterised by some form of brain impairment
116
What is the choice theory of addiction
o Choice theory- the apparent loss of control seen in those with a substance use disorder as a consequence of individuals changing their minds
117
How many standard drinks are a low risk amount for males?
4 or less
118
How many standard drinks are a low risk amount for females
2 or less
119
How many standard drinks are hazardous for males?
5-6
120
How many standard drinks are hazardous for females?
3-4
121
How many standard drinks are harmful for males?
7+
122
How many standard drinks are harmful for females?
5+
123
Is drink tolerance the same across all cultures?
No
124
Is there a genetic component to substance use disorders? What is the evidence for this?
• Strong genetic component to substance disorders (found from twin research) • Monozygotic twins show higher concordance rates for: o Alcohol, cannabis, tobacco o Stimulants o Hallucinogens, opioids o Sedatives • Likely that the genetic basis for substance dependence is largely non-specific, rather than unique to specific substances
125
What is the percentage of people who have addictions that give up on their own volition?
• 70% of people who meet addiction give up on their own volition
126
What is the procedure for psychological treatment of substance abuse?
``` • Procedure o Assessment o Evidence-based treatment o Substance use monitoring o Clinical and case management o Recovery support programs o Continuing care ```
127
What are the groups involved in psychological treatment for substance abuse?
``` o Vocational services o Mental health services o Family services o Legal services o HIV/AIDS services o Educational services o Medical services ```
128
What are the principles of effective management of substance abuse?
o No single treatment is appropriate o Treatment needs to be readily available and accessible o Effective treatment involves and attends to multiple psychological, medical and social interventions and needs  CBT  Naloxone  Antabuse  Methadone  Peer support  Aversive conditioning o Dual diagnosed clients should have both disorders treated in an integrated fashion o Treatment does not need to be voluntary to effect change o Recovery from drug addiction can be a long term process and frequently requires multiple episodes of treatment
129
What are the targets of substance use psychological interventions?
o Maladaptive behaviour patterns o Skills deficits+ resilience training o Motivational and cognitive barriers to change  Identify high risk situations and events (e.g. people, places, affect) and deduce likelihood that these events are encountered (providing alternative activities)  Target cognitive distortions enhancing likelihood of drug use (e.g. rationalising use or giving up on giving up
130
What 3 interrelated sub systems are activated with anxiety?
- Physical system - Cognitive system - Behavioural system
131
Describe how the physical system acts when anxiety is triggered
 Fight/flight response  Mobilises resources to deal with the threat- releases adrenaline which initiates bodily changes • Less saliva-dry mouth • Breathing rate speeds up. Nostrils and air passages in lungs open wider to get in air more quickly • Digestion slows down • Liver releases sugar to provide quick energy • Sphincter muscles contract to close openings of bowel and bladder • Immune responses decrease- useful in short-term to allow massive response to immediate threat- harmful over long • Muscles tense- ready for action • Blood is diverted to the muscles • Sweating increases to help cool the body • Heart beat speed up. Blood pressure rises • Blood clotting ability increases, preparing for possible injury
132
Describe how the cognitive system activates with increased anxiety
 Perception of threat  Attentional shift and hypervigilance on perceived threat  Difficulty concentrating on other information/situations
133
Describe how the behavioural system activates with increased anxiety
 Escape or avoidance  Aggression or freezing • Least safe option
134
What is the difference between true and false alarm?
o True alarms- when fear occurs in response to direct danger o False alarms- fight or flight response occurs in situations that do not represent an immediate physical threat- false alarms are the hallmark of anxiety disorders
135
What affects someone's tendency to perceive threat in ambiguous situations?
 Individuals differ in terms of the ease with which the alarm reaction is triggered: triple vulnerability includes • Biological factors o Inherit predisposition towards anxiety and depressive disorders- the general neurotic syndrome • Generalised psychological factors o Beliefs that the world is a dangerous place o Events are beyond one’s control • Specific psychological factors o Specific to particular objects or situations and include factors that influence the expectation of a negative outcome when confronted with a specific object or event – generalises to other objects/events with similar features
136
What affects someone's extent to which anxiety response is activated?
* Tendency to experience negative affect from positive affect and arousability of the autonomic nervous system * Negative affectivity- subjective distress * Positive affectivity- happy and enthusiastic
137
What are the 2 individual differences in trait anxiety?
- Tendency to perceive threat in ambiguous situations | - Extent to which anxiety response is activated
138
Is anxiety on a continuum? Why so? When does anxiety starts being abnormal and what maintains this anxiety?
o Anxiety is on a continuum o Not qualitatively different from normal anxiety o Same (physical, cognitive and behavioural) systems activated, but marked by excessive or inappropriate occurrence, characterised by overestimation of perceived cost/likelihood of a threat  Defines where you are on anxiety scale o Arise when the frequency and intensity of anxiety interferes with the person’s functioning/causes distress o Avoidance maintains and exacerbates anxiety
139
What are anxiety disorders characterised according to in the DSM?
o In DSM, anxiety disorders characterised according to focus of anxiety and what they try to avoid
140
Differentiate between DSM-IV anxiety disorders and DSM-V anxiety disorders
DSM-IV Anxiety disorders Seperation Anxiety Disorder ``` Specific Phobia Social Phobia Generalised Anxiety disorder Panic Disorder Panic disorder with agoraphobia Acute stress disorder Posttraumatic stress disorder Obsessive compulsive Disorder ``` ``` DSM-V anxiety disorders Seperation Anxiety Disorder Selective Mutism Specific phobia Social anxiety disorder Generalised anxiety disorder Panic Disorder Agoraphobia ```
141
What are the trauma and stressor related disorders in DSM-5
* Posttraumatic stress disorder * Acute stress disorder * Adjustment disorders * Reactive attachment disorder * Disinhibited social engagement disorder
142
What are the obsessive compulsive and related disorders in DSM-5?
* Obsessive-compulsive disorder * Hoarding disorder * Trichotillomania (hair pulling disorder) * Excoriation (skin-picking disorder) disorder * Body dysmorphic disorder
143
What is criteria A for social anxiety disorder?
: Marked fear or anxiety about one or more social situations in which the person is exposed to possible scrutiny by others e.g. social interactions, being observed, performing in front of others
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What is criteria for social anxiety disorder?
The individual fears that he or she will act in a way or show anxiety symptoms that will be negatively evaluated (that is, will be humiliating or embarrassing; will lead to rejection or offend others)
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What is criteria C for social anxiety disorder?
The social situations almost always provoke fear or anxiety
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What is criteria D for social anxiety disorder?
The social situations are avoided or endured with intense fear/anxiety
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What is criteria E for social anxiety disorder?
The fear or anxiety is out of proportion to the actual threat posed by the social situation and to the sociocultural context
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In DSM5 diagnosis of social anxiety disorder, the fear, anxiety or avoidance must be:
o Is persistent, typically lasting for 6 months or more  Flexible with specifying time- can diagnose those with social anxiety disorder with times for less than 6 months o Cause clinically significant distress or impairment in social, occupational or other important areas of functioning  If does not affect their lives, does not get diagnosis o Is not attributable to the physiological effects of a substance or another medical condition o Is not better explained by symptoms or another mental disorder, such as panic disorder, body dysmorphic disorder or autism spectrum disorder  Distinguish what person is fearing and avoiding  Body dysmorphic- avoidance because impression that one of their body parts is horribly wrong o If another medical condition (obesity, disfigurement from burns or injury) is present the fear, anxiety or avoidance is clearly unrelated or is excessive  Clinical judgement is involved
149
What is a specific sub category of social anxiety disorder?
o Performance only  Socially anxious only when they perform in public but completely fine in social situation  Fear restricted to speaking/performing in public  Impacts actors or musicians
150
What are the prevalence rates in adults within the past 12 months of social anxiety disorder in Australia?
Near 8%
151
Is there a difference in countries in the prevalence rates in adults within the past 12 months of social anxiety disorders? Why/why not?
o Lower rate in European and Asian countries  In some countries (Japan, Korea…), people are not as much afraid of negative evaluation by others, but fear they are offensive to others  In cultures that are highly collectivistic, there seem to be more social anxiety in the general population- people seem to judge each other more but less prevalence in terms of anxiety disorders-symptoms are not clinical: high social anxiety but not social anxiety disorder
152
What is the incidence of social anxiety disorder according to gender?
o In the general population: 1.5 higher in women o In clinical samples: gender rates are equal  Men seek treatment more often than women if they are socially anxious  Depends on culturally accepted gender roles  Less acceptable for men to be socially anxious than women in cultural
153
What is the typical age of onset of social anxiety disorder and why might they develop it at this age?
o Childhood or adolescence  75% will develop the disorder between the age of 8 years old and 15 years old  Might have high levels of shyness until it increases to become social anxiety disorder  Others: the disorder might trigger from traumatic experiences such as being bullied, rejected… o Not very common to develop disorder in adulthood  Would be due to crisis or traumatic situation
154
Without treatment, what is the chance of recovery for social anxiety disorder?
o Chronic without treatment o About 10% of people will recover within a year without any treatment o About 30% will be better by themselves within 2 years o About 60% will remain chronically anxious for most of their lives
155
How many people seek treatment for anxiety disorder and why is this so low?
o Only 50% seek treatment (20 years after the onset of symptoms- delayed treatment)  Difficult to seek treatment as embarrassment about symptoms
156
What are comorbid disorders associated with social anxiety disorder?
o Women tend to have more:  Other anxiety disorders  Depression o Men tend to have more:  Substance use (alcohol to cope with it better)  Avoidant personality disorder o But both genders can experience all of them
157
Is social anxiety disorder subject to genetic vulnerability?
• Genetic vulnerability- 2 to 3 fold increased risk of social anxiety disorder among the relatives of people with the disorder
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Is social anxiety disorder subject to psychosocial factors?
• Pyshosocial factors- excessive parental criticism may reduce child’s confidence, or child could learn from his/her parents and be overly concerned with the opinions of others
159
Describe Clark and Wells cognitive model of social anxiety disorder
• Expectation of entering social situation will trigger assumptions or long-standing beliefs that the person holds. Four different types of beliefs o Excessively high standards on themselves o Conditional beliefs about consequences of social performance -very negative expectations of what’s going to happen o Unconditional beliefs about self  Conditional beliefs will enhance the fact that you will make a mistake if you have the unconditional beliefs about self o Lead to perceived danger • All this will cause anxiety o Symptoms will start triggering • Interpret ambiguous social cues as signs of negative evaluation with expectation that it will go badly • Attention shifts to the self o Interpret internal cues as signs of how they are being seen by others o Hypervigilant to signs of anxiety o More you pay attention to yourself, the more anxious you get • Safety behaviours o Keep yourself safe to avoid negative behaviours o Hide signs of anxiety o Don’t make eye contact o Speak very quietly- don’t draw attention to yourself o Do not show signs of weakness  People can come across as cold and aloof  So people will not be friendly back- fears will be confirmed o Safety behaviours backfire o Interferes with ability to participate with conversation or look at social cues • Increase self-focused attention • Increase anxiety symptoms • Interfere with social performance • Confirm social fears
160
What happens in pre-event processing in social anxiety disorder?
``` o Anticipatory processing o Imagine/review what might happen  Anxiety  Avoid social event or enter in self-focussed processing mode o People will remember when I stuff up ```
161
What happens in post-event processing in social anxiety disorder?
o Remember negative aspects of the social situation  Sense of shame  Evaluating themselves with negative judgment  What they should have done differently  Everyone is talking about them/laughing about them o Remember similar past failures  Negative beliefs strengthened  Person is hopeless and can’t do this  Irrational about how much they might have offended the person/make them look stupid o Increase/maintain anxiety
162
What treatments are common for social anxiety disorder?
``` • Cognitive behavioural therapy (CBT) o First line evidence-based treatment o Aim: to reduce negatively biased threat appraisal  Reduce likelihood of negative event  Reduce cost of negative event  Increase exposure to event • Psycho-education • Cognitive techniques • Behavioural techniques • Reducing safety behaviours • Attention training • Video feedback • Exposure tasks with cognitive rationale • Often carried out in group settings • About 2/3 achieve substantial improvement ```
163
What is the biological approach to psychology?
• Biological approach- focus on genetic, hormonal, and neurochemical explanations of behaviour
164
What is the psychoanalysis approach to psychology?
innate drives of sex and aggression (nature). Social upbringing during childhood (nurture)
165
What is the cognitive approach to psychology?
Innate mental structures such as schemas, perception and memory and constantly changed by the environment
166
What is the humanism approach to psychology?
Maslow emphasized basic physical needs. Society influences a person’s self concept
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What is the behaviourism approach to psychology?
all behaviour is learned from the environment through conditioning
168
What is the cognitive-behavioural model and what are some treatments that stem from it?
o Dominant model in clinical psychology research and clinical practice  What we think influences how we feel and what we do o Maladjustment: latent core negative beliefs (Aaron Back)  Guide our understanding of the world  Interpretations of experiences are consistent with our core beliefs  Cognitive distortions/biases (e.g. overgeneralisations, selective attention, catastrophising, black and white thinking etc.)  Automatic negative thoughts o Treatment:  Cognitive restructuring • Challenging content of thinking  Exposure  Behavioural experiments
169
What is the new third wave of CBT and what does it involve/ how is it different from the old treatments?
 Modern (third wave) CBT and evidence based therapy A wider range of approaches from humanistic, existential, analytic and spiritual traditions • But should not practise just one thing because of different patients and different presentations of disorders  CBT’s focus on the content of symptoms changed to a process- based therapy  change from WHAT people think about to HOW people think  Symptom/syndromal/psychopathology focus weakens  Focus on a process
170
What are examples of new third wave CBT?
- Mindfulness based cognitive therapy - Acceptance commitment therapy - Dialectic behavioural therapy
171
Describe mindfulness based cognitive therapy
o Mental events o Don’t have to grab thoughts and make them feel like they are reality o Observe and distance yourself from thoughts/emotions o Don’t judge or identify them o Effective for reducing frequency of depressive relapses o Good for emotional regulation which is good for borderline personality disorder
172
Describe acceptance commitment therapy
o Assumes person is uncomfortable with negative and painful feelings o Try to tolerate feeling- feeling is temporary and necessary – it is just a feeling/thought o Do something despite the uncomfortable feeling o Psychological flexibility- being present, open, doing what matters to you o Contact with the present moment o Chosen values- Chosen values of a person and what can guide their behaviours  Commitment to values o Committed action- Effective mental and physical actions guided by values o Self as context- Observing self, pure awareness of thoughts, behaviours, moods o Thought defusion- observing thoughts as they come and go without attaching meaning or judgment, detaching from thoughts o Acceptance/willingness- open to whatever comes
173
Is it important to tailor psychotherapy components to the patient?
• Important to tailor psychotherapy components to the person o Different types of clients require different treatments/relationships o Applying an identical psychosocial treatment for all patients is inappropriate and perhaps even unethical  Want to personalise and treat holistically
174
What do clinical training programs now have to include?
• Clinical training programs now have to include training in evidence-based therapies to be accredited
175
Why is there a need for evidence-based treatment evaluation? Is this need old or new?
o The drive to identify evidence-based treatments is a relatively new idea  previously, client report was sufficient  Psychiatrists thought it was enough to see if therapy was effective if person had positive feedback, but would not look at dropout rate or worsening o Need for evidence-based treatment is due to a need for accountability: social/economic (third party payers) want to know that what they’re paying for is worth it and ethical accountability o Patient care can be enhanced by acquisition and use of up-to-date empirical knowledge o It is difficult for clinicians to keep up with newly emerging information pertinent to their practice o If do not keep up with newly emerging information, their knowledge and clinical performance will deteriorate over the years after their training o Clinicians need summaries of evidence provided by expert reviews and instructions on how to access this information during their routine practice
176
What study did the idea of a need for evidence based treatment come from?
• Study: Hans Eysenck o People receiving psychotherapy are not better (could be worse off) than no treatment o People recovered by themselves in about 2 years and found that therapy didn’t really help for everyone o Predominant theory during this time was psychoanalysis
177
What is the placebo effect in clinical treatment? What are factors of it and how could we determine whether there is one or not?
o Recent studies suggest that treatment is better than no treatment o But little or no specific effect when comparing two different treatments o Nonspecific factors could be responsible for this treatment effect, such as:  Client motivation and hope  Therapist empathy, general counselling skills  Therapist-client alliance • Have someone on their side o Need for placebo control groups which would reflect those general factors and there is a lack of power in study designs (hard to conduct clinical studies with patients that are not feeling well)  Hard to get large sample sizes in these studies
178
What is the criteria for well established treatments and who set this criteria?
 At least two good between-group design experiments (Randomised controlled trials-RTCs) must demonstrate that the treatment is superior to: • Placebo pill • Psychotherapy placebo o Needs to account for general effects- type of therapy that has the same duration, counselling aspect, validation and normalization of what person is feeling o What’s missing is the activate component of therapy that is being tested • Other treatment  OR equivalent to an already established treatment (with adequate sample sizes) o Set by APA task force on promotion and dissemination of psychological procedures
179
What are features of good experimental design?
o Random allocation of participants to treatment groups o Blind or double-blind design o Experiments must be conducted with treatment manuals or clear description of treatment enables precise replication o Characteristics of samples must be specified  Diagnoses, exclusion criteria etc (DSM)  Exclusion of comorbidity or not specification o Characteristics of therapists must be specified o Effects must be demonstrate by at least two different investigators or teams- to rule out experimenter bias
180
What is the criteria for promising treatment?
o At least 2 experiments show that the treatment is superior to the waiting list control group (rather than placebo control) o OR meets well-established criteria but experiments not carried out by 2 different teams
181
What is the criteria for emerging (experimental) treatments?
• Experimental treatments (emerging treatments) are those not yet tested in RTCs with adequate methodology o E.g. not randomised, pre-post only, not manualised
182
What are criticisms of evidence based research?
• EST findings will be: o Misused by managed care companies to disenfranchise practitioners of psychotherapies that are not so designated o Will make these same practitioners more vulnerable to malpractice suits o Will restrict practice to a limited number of treatments, thus precluding flexibility and clinical innovation • Reliance on DSM to describe samples • Reliance on treatment manuals • Reliance on randomised control trials
183
Why is the reliance on DSM to describe samples a criticism of evidence based research?
o Diagnosis is dehumanising o DSM medical model is not appropriate but need to evaluate generalisability somehow o Clarity of the criteria and methods for reaching decisions vague
184
Why is the reliance on treatment manuals a criticism of evidence based research
o Reduces treatment quality: treatment should be designed for individual cases but there is no data supporting this contention (no evidence that they don’t work)  Tailoring more relevant for complex disorders o Limits generalisability: clinicians don’t normally use treatment manuals but may they should
185
Why is the reliance on randomised control trials a criticism of evidence based research?
o Advantage for CBTs  CBT is structured  Measurable  Observable o Findings are unlikely to generalise to ordinary treatment settings  strongest argument against evidence-based research findings  Efficacy vs effectiveness (internal vs external validity)  Treatment not necessarily equally effective if used in: • Private practise, community mental health settings or unselected client base o Ecological validity is an issue o Some evidence for external validity, but effects sizes are often lower  Are working in real life, but not to same extent as clinical trials o More research is needed
186
Do mental professionals work in a team or individually?
* Differ in approaches to understanding and treating mental illness, each having different but complementary skills  holistic treatment/support * May work independently or as part of a multi-disciplinary team
187
What are the characteristics of an effective psychologist?
• Empathy and genuine concern: active listening and reflection o Builds an open and trusting rapport with client/patient • Appropriate boundaries: maintaining appropriate personal distance • Trustworthiness: confidentiality emphasised (exceptions explained) • Patience: guiding the client in the process of self-discovery • Solid ethical core: openness, honestly, transparency • Cross-cultural sensitivity: self-awareness and commitment to diversity • Scientist-practitioner: commitment and passion for a life-long learning o Provides individualised/tailored psychotherapy
188
What is a concurrent schedule?
Animals are given the opportunity to engage in two or more responses that are reinforced according to separate schedules that are running at the same time
189
What is the equation for rate of behaviour?
* Rate of behaviour- B * Rate of reinforcement- R * Slope constant-K * B=kR
190
What is the relative rate of responding of B1 compared to B2?
• We have two behaviours performed at different rates o B1, B2 • Relative rate of responding of B1 is: B1/ (B1+ B2)
191
What is the relative rate of responding of R1 compared to R2?
* The behaviours are reinforced given at different rates- R1, R2 * The relative rate of reinforcing of R1 is: R1/(R1+R2)
192
What are the equations of the matching law and what is the matching law useful for?
• B1/B2= R1/R2 • B1/(B1+B2) = R1/(R1+R2) o Matching law  Describes the choice in concurrent schedules of reinforcement o The distribution of behaviour can be predicted by the history of the distribution of reinforcement o Change relative rates of behaviour by changing relative rate of reward
193
What is the schedule matching law?
* T1 and T2- schedules | * T1/T2=R1/R2
194
What is the value matching law?
* V1 and V2- values | * B1/B2= V1/V2
195
What are possible explanations for the matching laws?
• Animals might choose to respond on one alternative or the other on a moment-to-moment basis so as to maximise the momentary rate of reinforcement • Animals choose in a way that somehow maximises the overall rate of reinforcement In the whole session • Animals might keep shifting between the alternatives so as to always improve the local rate of reinforcement o Melioration- stop shifting between alternatives when the two local rates of reinforcement are equal
196
What are the criticisms of matching laws?
* Sometimes, animals overmatch so that B1/B2 is consistently a little greater than R1/R2 * Other times, animals undermatch and B1/B2 is a little less than R1/R2
197
Describe Madsen et.al's study on how differential reinforcement of other behaviours reduces an unwanted behaviour
• Madsen et.al o Reinforce alternate behaviour o More kids out of their chairs when the teacher yelled sit down o Artistic work in a book instead of going out of chairs- praised them for working  Kids praised for alternative behaviour to being out of chair and running around  Doesn’t introduce aggression in the situation • Change relative rate of behaviour by reinforcing other behaviours instead
198
If your situation in some part influences your behaviour, what can you do to change that behaviour?
• If your situation in some part influences your behaviour, then modifying your environment will modify your future behaviour: o Behaviours that alter future behaviours  Stimulus control (e.g. studying)  Distraction (ignoring easy options)  Precommittment  Self-reinforcement (reward self for achieving targets)
199
What is self-control?
o Delaying immediate gratification for a bigger longer-term reward
200
What is impulsivity?
o Forgoing a larger long-term reward for immediate gratification
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What is the subjective value of a small but immediate reward vs a large but delayed one? What is an exception to this?
• A more immediate but smaller reward can have a larger subjective reward value at the time of choice, than a delayed but larger reward o But increase the time until choice, and the subjective value of the smaller reward decays as well to a level that’s below the more valuable delayed reward • But when the average choice-to-reward delay is relatively short, choose the smaller, more immediate reward. When the choice-to-reward delay is relatively long, choose the larger, more delayd reward
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Why do we choose the more immediate smaller reward compared to the larger but delayed reward?
• Risk of losing reward o For each period of time (Delay,D) there is a risk (r ) that the reward (A) may be lost. This risk is compounded for each period of time o This predicts an exponential curve for the present value of a delayed reward to be B=Ae(-rD) o However, behavioural data does not fit this but better fits a hyperbolic function -devaluation curve  Subjective decay in value o Intertemporal choice- immediate gratifications vs holding out for something in the future • Expected transaction costs o More effort to come back for reward later when there is one right in front of you • Concave utility effects on reward o Rewards have subjective value depending on how much the person has of that reward if have a lot of that reward, increased amount will be needed to be meaningful. If have little of that reward in the first place, even a small amount of reward will be motivating
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How can you increase self-control?
* Make the immediate rewards less obvious * Distraction from the immediate rewards * Delay the immediate reward too * Make the longer term rewards or risks more salient * Exercise
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Talk about lyengar and Lepper's study about choice
• Iyengar and Lepper o If given a choice between 6 jams or a choice between 24 jams:  6 choices: 40% stopped at booth, 30% bought  24 choices: 60% stopped at booth, 3% bought o If given a choice between 6 essay topics or 24 essay topics for extra credit:  6 choices: 74% completed the essay  24 choices: 60% completed  Limited choices essays were better technically and intellectually o No-choice, limited choice, wide choice of chocolates:  Frustration: Wide choice > limited choice  Satisfaction of chocolate: limited choice >wide choice > no choice  Purchasing: Limited choice (48%) > wide choice (12%) = no choice (10%)
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Why do too many options reduce choosing?
o Escalation of expectations o Regret and anticipated regret with choice o Opportunity cost o Self-blame
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What is the marshmellow test and what supplementary studies were done on it?
 Watts Et.Al. • Replicated marshmallow test (where have one marshmallow in front of you and if wait for a bit get 2 marshmallows) • Accounted for socioeconomic status • Found that self-control vs impulse of a person was largely controlled by their environment
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Describe Bickel et al's study
* Changeable across individuals * Current smokers underestimate subjective values of future rewards  more immediate reward choosing * Smokers who quit have the same level of immediate vs delayed reward choosing than people who’ve never smoked, which is more delayed reward choosing than current smokers
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What is neuropsychology?
• Matching structure and functions of the brain to psychological processes: o Experimental neuropsychology aims to match behaviour, mood and cognition to brain functioning o Clinical neuropsychology aims to understand, assess, treat psychological disorders with reference to abnormal brain functioning
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What is neurology?
o Largely concerned with neural physiology
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What is psychology?
o Seeks to understand psychological processes at different levels of explanation
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What is psychiatry?
o Effects of drugs on mood and thinking
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What is phrenology and who was it proposed by?
o Gall o Brain consists of many mental organs, each dedicated to particular mental function o Hypothesis:  If used a lot, that part of the brain becomes bigger  Should read bumps on head to see which sections of the brain are more developed  Skull shifts to accommodate for this  However, the part of the brain does not get bigger, and there was no evidence for this so it was scrapped
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What are the suggested domains of function in phrenology?
```  Form  Size  Weight  Colour  Arithmetic calculation  Locality (topographic learning and memory)  Eventuality (memory for facts)  Time  Music  Language ```
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What are the three main sources of evidence that function can be localised to structures?
• Three main sources of evidence that function can be localised to structures include: o The effect of accidental (via disease or injury) or experimental lesions on psychological functions o Psychological effects of stimulation o Recording neural activity while doing tasks
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What can lesions in the brain do? What is the difference between Broca's and Wernicke's aphasia and their location?
o Lesions in brain can cause rapid and psychological change o Localisation of language by lesions (Broca and Wernicke)  Broca and Wernicke’s aphasia • Broca’s patient was Mr Tan • Wernicke- patient can’t understand what is being said to him o Fluent in producing speech but speech has no meaning o Where temporal lobe joins the parietal lobe • Broca’s aphasia- can’t say what they want to say o Damage in left prefrontal cortex
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What is the advantage of experimentally induced lesions?
o Experimentally induced lesions- animals  Chemically induce lesions in brains and examine the effect on function  Requires multiple tests to delineate function of the region  Can repeat among individuals  Can use specific types of techniques for lesions  More accurate as choose where lesion is – more experimental control
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What did Kobinian Brodmann do?
o Kobinian Brodmann  Used the Nissl method of staining to look for the fine structure of the brain  Allowed him to see that the brain is organised into morphologically and structurally distinct regions where the cell shapes and sizes differ from each other  Mapped these regions and divided the cortex into structurally distinct regions
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What are brain atlases and how are they made?
o Mapping anatomically distinct regions of the brain- modern atlases  Brains stained with dye  Fine grained map of all regions  Can look at types of neurons and chemoarchitecture
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What are directly implanted electrodes, what do they do and what are their advantages/disadvantages
* Great spatial and temporal acuity * Requires surgery * Placed on cortex of person’s brain, then connected to computer which finds signals * Recording activity whilst people are doing/thinking about things
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What is electroencephalogram, what does it do and what is their advantage/disadvantage?
* Great temporal acuity, poor spatial accuracy * Read surface activity of brain- can see localisation of activity * Can only measure activity below skull * Millisecond accuracy
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What does MRI (magnetic resonance imaging) do?
 uses magnetic fields and radio waves to produce high quality images of brain structures  Does not use ionizing radiation (X rays) or radioactive tracers  Excellent resolution of 2-3 mm
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What does fMRI (functional magnetic resonance imaging) do and what are their disadvantages?
 Measures the real-time response of oxygen in the blood stream (different response when bound to haemoglobin) in response to stimuli/tasks, then superimposes that information onto an MRI  Typically requires a rest period (for control), then a task • When there is an increase in activity during task, that part of the brain is used in the task  Can see where brain is doing work by migration of oxygen  Takes 20-30 seconds for whole brain scan  Poor spatial and very poor temporal resolution  Voxels by voxels analysis for graph • Increasing error rate in making poor rejection of null hypothesis because of low power
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What is Positron Emission Tomography and what are its advantages/ disadvantages?
 Measures emissions from radioactively labelled chemicals injected into the bloodstream • Can see where tracers go in the body  Different compounds can show different things  Tasks must be very short because of decay  Good idea about processes going on in brain- types of neurochemical processes depending on radiolabels we use  Very poor spatial and temporal resolution
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What is magnetoencephalography and what are its advantages/disadvantages?
 Measurement of the magnetic fields produced by electrical activity in the brain  Excellent temporal resolution • Millisecond accuracy  Poor spatial resolution  Unlike EEG (electrical) skull does not impede measurement
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What was revealed from a dead salmon's fMRI?
Atlantic salmon --Said to react to pictures of humans but it was dead --Found some activity due to chance Shows: -Poor choice of control tasks, leading to poor conclusions -Too little statistical power means that chance results are accepted too readily -Correlational data
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What is the problem with lesions?
Problem determining which particular function(s) have been changed: - -Accidental lesions: - ----Little data on pre-accident functioning of the individual - ----Most detailed neuroanatomy in humans can only be done post-mortem: brain can change a lot in the meantime - -Experimental lesions - ----Usually done in animals, so functional testing is more limited - ----Problem of determining if structures are homologous with humans
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What is the problem of neuroimaging?
- ----Spatial resolution is not as clear as post-mortem analysis - ----Correlational data
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How can we localise function to specific regions of the brain?
- Lesions - Cytoarchitectonics and advances in neuroanatomy - Measuring neural activity - Neuroimaging
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What is the Montreal Procedure and who was it done by?
• Montreal procedure- Penfield: would ablate part of the brain responsible for epileptic features o Stimulated brain to make sure he didn’t take out anything important and asked the person what they were feeling
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What are the problems with subscribing function to single locations?
- Plasticity in the cortex and developmental effects - Redundancy and pleiotropy - Mass effects and network connectivity of structures - Context-dependent effects
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Why is plasticity in the cortex and developmental effects a problem to subscribing function to single locations and what are examples of this?
 Brain changes as you age  Changes in one part of the brain can have downstream/compensatory effects in other parts of brain, especially at key developmental stages  If one area of the brain is damaged, the functions can be remapped onto new parts of the brain • Blind people use the visual cortex to discriminate Braille, but there’s a critical period for an increase in visual cortex activity. o Tends to occur in people who were blind from birth or young • TMS of the visual cortex produces phosphenes in sighted people and paraesthesia in the fingers of blind Braille readers o Ptito-  Draw what phosphenes looked like- different mapping in brain  Did same things with people in Braille- variation in remapping
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What is redundancy?
multiple parts of the brain can do similar functions e.g. memory
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What is pleiotropy?
one part of the brain can have multiple functions
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Why are network connectivity of structures a problem in assigning a function to a specific part of the brain?
 Functions may require a network of regions correlating activity with each other in a specific way  Degrading single nodes of the network does not necessarily reduce the function of the whole network
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What is mass action and who proposed it?
• Karl Lashley o Mass action:  If cortical tissue is destroyed following the learning of a complex task, deterioration of performance on the task is determined more by the amount of tissue destroyed than by its location  Experiences are distributed across the brain, so damage to specific part of the brain won’t affect it-damage has to be mass effect
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What is equipotentiality ?
 One part of the cortex can take over the function of another part
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What is diffusion tensor imaging?
 Diffusion tensor imaging- imaging white matter connectivity • Damage may be to the connections between regions • Measure flow of water through brain • Mathematically model synaptic regions
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What is network analysis?
 Network analysis- the default mode network • Functional correlations in activity between connected regions may be affected • Default thought network in brain can predict different pathologies
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What are context-dependent effects?
 The context can influence how a region of the brain functions during a given activity  The background emotional state can influence how regions of the brain respond to stimuli
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What do clinical neuropsychologists do and who do they belong to?
• A college within the Australian Psychological Society o Most practitioners work within health service teams in hospitals or private practice o Provide advice on assessment, diagnosis, treatment and rehabilitation o Research into the neural basis of psychological functions
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What are the 6 major reasons for assessment?
 Diagnosis, patient care and its planning, treatment planning, treatment evaluation, research and forensic neuropsychology
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How do you carry out individual assessment?
* How has the person changed from previous function? | * Is the person declining across longitudinal assessments?
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How do you carry out a normative assessment?
• How is the person’s function compared to their peers in standardised tests?
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What is the assessment process?
 History taking in a clinical interview  Selection of the appropriate tests  Report writing for clinicians, the client, their family or carers
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What standard tests are available?
 Standard tests to assess cognitive and emotional disorders are commercially available to assess a range of cognitive domains: • Working memory, executive function, verbal or spatial memory, attention etc.
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What should a good test be?
• Valid for the function assessed • Reliable across people and within a single person • Normative data against large populations • Standardised instructions so they can be conducted in a variety of contexts o The test items do not vary o The test instructions are read from a manual in the same way o The testing environment is arranged in a specific way  E.g stroop test (colour and word are different) • Valid across a variety of cultural settings and developmental stages
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What is the CANTAB test battery?
 Designed to use tasks that don’t rely on language  Reduced cultural effects  Portability and automaticity  Data collections to aid standardisation, and validity and reliability testing