Abnormalities of haemostasis Flashcards Preview

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Flashcards in Abnormalities of haemostasis Deck (17)
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1

For how long does epistaxis have to not be stopped to be a positive history for coagulopathy?

10 mins

2

What are the 2 categories of cause of coagulopathy?

Lack of a specific factor
Dysfunctional factor

3

What is thrombocytopenia a defect of?

PRIMARY haemostasis

4

Recall causes of bone marrow failure

Leukaemia
B12 deficiency

5

Recall 2 causes of accelerated clearance of platelets

Immune
DIC

6

Recall 5 possible causes of thrombocytopenia

Increased clearance
Bone marrow failure
Failure of production by megakaryocytes
Shortened t1/2
Splenic sequestration

7

What is Glanzmann's thrombasthania a disease of?

Glycoprotein absence

8

What is Bernard Soulier syndrome a disease of?

Glycoprotein absence

9

Recall 2 drugs that can impair platelet function

Aspirin
Clopidogrel

10

How many types of vWF disease are there? Recall the inheritance patterns of each

3
1 + 2 = autosomal dominant
3 = autosomal recessive

11

Name a congenital vessel wall disorder

Hereditary haemorrhagic telangiectasia Ehlers-Danlos syndrome

12

What is haemophilia a disorder of?

Secondary haemostasis

13

Why does DIC lead to defective secondary haemostasis?

High TF concentration --> increased consumption of factors

14

Describe the differences between platelet and coagulation disorders

Platelet: superficial and immediate bleeding
Coagulation: deep and delayed bleeding

15

Recall 4 things that may be given to replace factors in coagulopathy

1. Plasma (all factors)
2. Cryoprecipitate (fibrinogen, F8+9 and vWF)
3. Pooled platelet concentration
4. Concentrate of a specific factor

16

Why can DDAVP be useful in coagulopathy?

Causes rise in vWF and factor VIII

17

What is tranexamic acid used for in coagulopathy?

Inhibition of fibrinolysis