Acid-peptic disorders Flashcards Preview

Pharm II Exam 4 > Acid-peptic disorders > Flashcards

Flashcards in Acid-peptic disorders Deck (27):
1

What are examples of sodium bicarb antacids

baking soda
alka seltzer

2

Unique ADE of sodium bicarb antacids

may exacerbate fluid retention in HF, HTN, and Renal insufficiency pts

3

Example of Calcium carbonate antacids

tums

4

2 ADEs of sodium bicarb and calcium carbonate antacids

-CO2 gastric distention
-belching

5

If you want to advise your patient to take antacids but want to avoid the AED of belching, what kind of antacid do you prescribe?

Magnesium/aluminum hydroxide

6

How do H2 receptor antagonists work?

-competitive inhibition of H2 cells
-reduce acid secretion and volume
-ALSO reduce acid secretion stimulated by histamines
-do not affect H1 receptors

7

What 2 populations should H2 receptor antagonists be avoided in?

Pregnant/breastfeeding- crosses the placenta

elderly pts w/ renal dysfxn- can cause mental status changes

8

Examples of H2 receptor antagonists

-cimetidine
-ranitidine

9

Examples of PPIs

omeprazole
pantoprazole

10

how do PPIs work?

inactivation of acid pumps, no effect on quiescent pumps

11

What are some ADEs of PPIs

diarrhea
B12 deficiency
iron, calcium, magnesium deficiency
Nosocomial PNA
c. diff infection

12

how long does it take for PPIs to wear off

takes 18 hrs for new H+ molecules to be formed
can last up to 24 hrs

13

when instructing a pt on when to take PPIs, what is important about the time the medication is taken

bioavailability of decreased by ~50% w/ food, so take 30-60 mins before meal (usu breakfast)

14

How does Sucralfate work?

forms a viscous paste that coats ulcers for 6 hrs

stimulated mucosal prostaglandin/bicarb secretion

prevents stress related bleeding

15

Example of Prostaglandin analog

Misoprostol

16

what are the primary GI mucosal prostaglandins?

E & F

17

True or false:
Acid suppression is more dependent on irreversible inactivation of the proton pump than the pharmacokinetics of different agents

Trueeee

18

Decreased gastric acidity from PPI may alter absorption of what drug?

digoxin

19

Omeprazole may inhibit metabolism of what drug?

warfarin

20

What PPI has no significant drug interactions?

Pantoprazole

21

How do Prostaglandin analogs work?

inhibits acid secretion
and
protects the mucosa

22

what are the uses of Prostaglandin analogs?

reduce NSAID-induced ulcers less than 3% and the incidence of ulcer complications by 50%

23

What group of people should prostaglandin analogs not be used in and why?

Pregnant people!
stimulates contractions

24

how does bismuth work?

coats ulcers and erosions, creating a protective layer against acid and pepsin

also has direct antimicribial effects- preventing and treating traveler's diarrhea

25

ADEs of bismuth

black stools
darkening of tongue
renal insufficiency
bismuth toxicity
salicylate toxicity

26

AED of Sucralfate

constipation

27

What is the FDA approved treatment for H pylori

Clarithromycin triple:
-PPI
-Clarithromycin
-Amoxicillin or Metronidazole