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Midterm Reviewer > Acidimetry And Alkalimetry > Flashcards

Acidimetry And Alkalimetry Flashcards

1
Q

One of the primary methods used in the determination of content of many pharmacutical substances and excipients

A

Acid - base titrations

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2
Q

Titrations of this nature follow the concept that acid and bases when combined well form it’s correspondings salt and water where at completion will have a shift in PH to which equivalency and endpoints depend on

A

Acid and base titrations

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3
Q

This essentially involves the direct or residual titrimetric analysis of alkaline substances (base) employeing an aliquot of acid and is provided usually in the analytical control of a large number of substances included in the various official compendia

A

Acidimetery

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4
Q

Urea,

A

Acidimetry: Organic Substances

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5
Q

Sodium bicarbonate

A

Acidimetry: Inorganic substances

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6
Q

Sodium Salicylate

A

Acidimetry: organic substances

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7
Q

Milk of magnesia

A

Acidimetry: Inorganic substances

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8
Q

Diphenhydramine

A

Acidimetry: organic substances

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9
Q

Amonium chloride

A

Acidimetry: Inorganic substances

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10
Q

Emetine hydrochloride

A

Acidimetry: organic substances

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11
Q

Calcium Hydroxide

A

Acidimetry: Inorganic substances

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12
Q

Meprobamate

A

Acidimetry: organic substances

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13
Q

Lithium carbonate

A

Acidimetry: Inorganic substances

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14
Q

Paramethadione

A

Acidimetry: organic substances

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15
Q

Zinc oxide

A

Acidimetry: Inorganic substances

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16
Q

Pyrazinamide

A

Acidimetry: organic substances

17
Q

Conducted by introduction of a standard acid solution gradually into a solution of the base being assayed until chemically equivalent amounts of each have reacted by some change in properties of the mixture

A

Direct titration method

18
Q

This is used whenever the end point of a direct titration deviates appreciably from the stoichiometric point for the following reasons

A

Residual or back tritation

19
Q

Basic sample is insoluble in water

A

Residual (back titration)

20
Q

Rate of reaction with acid is relatively slow

A

Residual or back titration

21
Q

When the substance under determination fails to give a sharp and distinctly visible end point with an indicator by direct titration

A

Residual or back titration

22
Q

In usual practice the residual titration is accomplished by allowing to dissolved the substance under estimation in an accurately measured quantity of a standard solution of known strength present in excess and subsequently titrating the excess of the latter with another previously standardized solution

A

Residual or back titration

23
Q

N1

A

Normality of acid added with analyte meq / L

24
Q

N2

A

Normality of base in the buret in meq / L

25
Q

V1

A

Volume of acid added with analyte in mL

26
Q

V2

A

Volume of base in the burette in mL

27
Q

Formula for direct titration method

A
28
Q

Formula for residual or back titration

A
29
Q

Formula for percentage purity of residual titration

A
30
Q

Acidic substances are usually determined quantitatively by methods similar to those use for the quantitative determinations of bases

A

Alkalimetry

31
Q

The quantitative measurement ( direct or residual ) of acidic substances using a basic standard solution

A

Alkalimetry

32
Q

What are the two methods of Alkalimetry

A

Direct and residual titration method

33
Q

Directly titrating an exact quantity of the acid, acid salt, acidic substances, with standard alkali solutions

A

Alkalimetry: Direct titration methods

34
Q

Addition of an excess of the standard alkali solution and subsequently determining the amount in excess by residual titration with standard acid solution

A

Alkalimetry: Residual titration methods

35
Q

Three principles in alkalimetry

A

Normality of the solution obtained by dissolving the acidic substance must be approximately the same as that of a titrant

The liquid acidic substance to be titrated must be brought to room temperature of (25°C ) before titration because many indicators offer different values at different temperatures

The quantity of acid to be taken should be calculated in such a manner that approximately 30 to 40 ml of the previously standardized base shall be utilized for the assay

36
Q

Indicators for inorganic acids

A

Methyl red and phenolphthaleim

37
Q

Indicators for organic acids

A

Phenolphthalene, bromothymol blue thymol blue and thymolphthalein

38
Q

This method is mostly applicable to official compounds belonging to the class of esters, acid anhydrides , aldehydes and acid chlorides

A

Residual titration method

39
Q

In practice this method applies to such substances that normally react to slowly without titrant because of their poor solubility precipitation method so as to convert the substance capable for reaction with the standard base

A

Residual titration method

Midterm Reviewer (4 decks)

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