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Coagulation > Acquired Coagulation Disorders > Flashcards

Acquired Coagulation Disorders Flashcards

1
Q

Specific Factor Inhibitors Causes

A

Therapy for factor deficiency
Postpartum
Medications

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2
Q

Specific Factor Inhibitors Clinical Presentation

A

Bleeding
No Response to Therapy - biggest clue to developing inhibitor

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3
Q

Specific Factor Inhibitors Laboratory Testing

A

Increases (prolonged) in associated screening tests
Inhibitor titer
Correction/Partial Correction with saline

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4
Q

Specific Factor Inhibitors Therapy

A

Overcome inhibitor
Non-human factor concentrate (bovine or porcine)
Plasmapheresis

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5
Q

Lupus Inhibitor Causes

A

Antibody directed against phospholipid
SLE
Medications
Immune disorders

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6
Q

Lupus Inhibitor Clinical Presentation

A

Usually thrombosis

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7
Q

Lupus Inhibitor Laboratory Testing

A

APTT - prolonged

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8
Q

Lupus Inhibitor Therapy

A

Steroids - first line of therapies

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9
Q

Vitamin K Deficiency Causes

A

No carboxylation of Vitamin K dependent factors
Dietary
Malabsorption
Coumadin therapy

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10
Q

Vitamin K Deficiency Clinical Presentation

A

Bleeding

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11
Q

Vitamin K Deficiency Laboratory Testing

A

PT - prolong
APTT - prolonged
BT - normal
TT - normal
Fibrinogen - normal

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12
Q

Vitamin K Deficiency Therapy

A

Vitamin K

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13
Q

Disseminated Intravascular Coagulation (DIC) Laboratory

A

PT - prolonged (factor consumption)
APTT - prolonged (factor consumption)
FSP/D-Dimer - fibrinolysis (positive)
TT - prolonged (factor consumption & increased FSP)
Fibrin monomer - positive
Abnormal ELT (Euglobulin Lysis Time) - fibrinolysis
Fragments on PBS (RBC frags on smear)

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14
Q

DIC Treatment

A

Underlying cause
Replace factors
Heparin
Anti-platelet drugs

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15
Q

Primary Fibrinolysis Cause

A

Increased fibrinolysis without increased clotting
Associated with extensive trauma
TPA released - breakdown of fibrinogen

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16
Q

Primary Fibrinolysis Clinical Presentation

A

Bleeding

17
Q

Primary Fibrinolysis Laboratory Testing

A

PT - prolonged
APTT - prolonged
TT - prolonged
FSP - increased
Platelet Count - Normal (important to distinguish btwn DIC)

18
Q

Primary Fibrinolysis THerapy

A

Treat underlying cause
Supportive

19
Q

Liver Disease Cause

A

Cause of liver disease (such as alcoholism)
Decreased Factor synthesis
Increased toxins - due to liver unable to keep up
Decreased liver clearance of FSP

20
Q

Liver Disease Clinical Presentation

A

Bleeding

21
Q

Liver Disease Laboratory Testing

A

PT - prolonged
APTT - prolonged
TT - prolonged
FSP - increased
Platelet Count - normal to abnormal

22
Q

Liver Disease Therapy

A

Treat underlying cause
Supportive

Coagulation (6 decks)

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