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Coagulation > Coagulation General Information > Flashcards

Coagulation General Information Flashcards

1
Q

Factor I Name

A

Fibrinogen

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2
Q

Factor I Inherited Frequency

A

Rare

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3
Q

Factor I Conversion

A

Fibrin by thrombin

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4
Q

Factor II Name

A

Prothrombin

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5
Q

Factor II Inherited Frequency

A

Rare

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6
Q

Factor II Comment

A

Precursor to thrombin

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7
Q

Factor III Name

A

Tissue Factor (TF)

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8
Q

Factor III Comment

A

Phospholipid released from injured vessel wall
Not normally found in blood

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9
Q

Factor IV Name

A

Calcium

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10
Q

Factor IV Comment

A

Bound by anticoagulant sodium citrate
Using citrated plasma, must be supplied by reagent

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11
Q

Factor V Name

A

Labile factor
Proaccelerin

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12
Q

Factor V Inherited

A

Rare

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13
Q

Factor V Comment

A

Deteriorates rapidly

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14
Q

Factor VII Name

A

Stable factor
Preconvertin

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15
Q

Factor VII Inherited

A

Rare

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16
Q

Factor VIII Name

A

Antihemophilic factor

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17
Q

Factor VIII Inherited

A

Common
Hemophilia A

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18
Q

Factor VIII Comment

A

Circulates in association with VWF

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19
Q

Factor VIII:C

A

Coagulation portion
Extremely labile

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20
Q

Factor IX Name

A

Christmas factor
Plasma thromboplastin component

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21
Q

Factor IX Inherited

A

Common
Hemophilia B

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22
Q

Factor X Name

A

Stuart factor

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23
Q

Factor X Inherited

A

Rare

24
Q

Factor XI Name

A

Plasma thromboplastin antecedent

25
Q

Factor XI Inherited

A

Rare
Hemophilia C
May or may not cause bleeding

26
Q

Factor XII Name

A

Hageman factor
Contact Factor

27
Q

Factor XII Inherited

A

No bleeding

28
Q

Factor XII Comment

A

Glass activation factor
Not part of invivo coagulation

29
Q

Factor XIII Name

A

Fibrin stabilizing factor

30
Q

Factor XIII Inherited

A

Rare
Poor Wound healing

31
Q

Factor XIII Comment

A

Stabilizes fibrin clot

32
Q

Factor HMWK Name

A

High Molecular Weight Kininogen
Fitzgerald Factor

33
Q

Factor HMWK Inherited

A

Rare
No Bleeding

34
Q

Factor HMWK Comment

A

Not part of in vivo coagulation

35
Q

Factor PK Name

A

Prekallikrein
Fletcher Factor

36
Q

Factor PK Inherited

A

No Bleeding

37
Q

Factor PK Comment

A

Not part of in vivo coagulation

38
Q

Substrate

A

Substance changed by an enzyme
Fibrinogen

39
Q

Cofactor

A

Protein that accelerates enzymatic reactions
No enzymatic activity of its own
V (cofactor for Xa)
VIII (cofactor for IXa)

40
Q

Enzyme

A

Protein that catalyzes a change in specific substrate
Secreted in inactive form (proenzyme, zymogen)
Must be activated to function

41
Q

Examples of Enzyme

A

Serine proteases
Thrombin (IIa)
VIIa
IXa
Xa
XIa
XIIa
Prekallikrein
Transglutaminase: XIIIa

42
Q

Contact group

A

Factors involved in initiation of intrinsic pathway
PK, HMWK, XII, XI

43
Q

Prothrombin Group

A

Vitamin K dependent factors
II, VII, IX, X

44
Q

Fibrinogen group

A

Factors acted on by thrombin
High molecular weight proteins
I, V, VIII, XIII
V, VIII, XIII - activated
I - converted to fibrin

45
Q

Factors in extrinsic pathway

A

TF, VII

46
Q

Factors in intrinsic pathway

A

PK, HMWK, XII, XI, IX, VIII

47
Q

Factors in common pathway

A

X, V, II, I

48
Q

Extrinsic tenase complex

A

VIIa, TF
Acts on X

49
Q

Intrinsic tenase complex

A

IXa, VIIIa
Acts on X

50
Q

Prothrombinase complex

A

Xa, Va
Acts on prothrombin

51
Q

Factor VIII complex

A

VIII:C & Von Willebrand factor (VWF)
VIII:C is the procoagulant
VWF is the carrier protein

52
Q

All produced in which organ?

A

Liver

53
Q

Factors Needed Vitamin K

A

II, VII, IX, X

54
Q

Affected by anticoagulant therapy

A

Coumadin, Warfarin
II, VII, IX, X

55
Q

Factors consumed during clotting

A

I, II, V, VIII, XIII
Not present in serum

56
Q

Labile Factors

A

V, VIII

Coagulation (6 decks)

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