Acute and Critical Care Flashcards

(171 cards)

1
Q

What is the threshold for immediate treatment of hyperkalaemia (with and without ECG changes)?

A

Serum potassium
- Greater than 6mmol/L with ECG changes
Greater than 6.5mmol/L without ECG changes

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2
Q

Cardiogenic causes of pulmonary oedema

A
Heart failure
Myocarditis
Tamponade
Pulmonary embolism
Valve disease
NSAIDs, ACEi
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3
Q

Non-Cardiogenic causes of pulmonary oedema

A
AKI
Renal artery stenosis
Sepsis
Altitude
Liver failure
Acute respiratory distress syndrome
Head Injury
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4
Q

Symptoms of acute pulmonary oedema

A
SOB ± orthopnoea
S3 sound
Gallop rhythm
Wheeze
Pink frothy sputum
Fine crackles
Sweaty
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5
Q

Common infective organisms in COPD exacerbations

A
H. influenzae
Strep pneumoniae
Staph aureus
Rhinovirus
Influenzae
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6
Q

ECG findings in PE

A
Right Axis Deviation
RBBB
Tachycardia
S1Q3T3
- Large S Wave in Lead 1
- Q wave in Lead 3
- Inverted T wave in Lead 3
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7
Q

PE Management (normal)

A

LMW Heparin or Fondaparinux
Aim for INR >2
Continue warfarin or NOAC for 3 months

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8
Q

Thrombolysis in PE

A

10mg IV Alteplase then 90mg infusion over 2 hours

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9
Q

PE Management in renal impairment

A

Unfractionated heparin

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10
Q

What score on the Two-Level Well’s Score suggests a PE is likely?

A

4 or more

less than 4 is PE unlikely

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11
Q

Management if PE likely on Two-Level Well’s Score

A

Offer CTPA, or immediate AC if CTPA not available immediately

V/Q SPECT scan if CTPA not suitable/ allergy to contrast media

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12
Q

Management if PE unlikely on Two-Level Well’s Score

A

Offer a D-Dimer

If positive, investigate as PE likely

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13
Q

Antibiotic management of mild Community acquired pneumonia

A

Amoxicillin

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14
Q

Antibiotic management of moderate CAP

A

Amoxicillin + Clarithromycin

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15
Q

Antibiotic management of severe CAP

A

Co-Amoxiclav/ Cephalosporin + Clarithromycin

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16
Q

Antibiotic management of HAP

A

Aminoglycoside IV + Antipseudomonal penicillin/ cephalosporin

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17
Q

Common CAP organisms

A

Strep pneumoniae
Haemophilus influenzae
Mycoplasma pneumoniae
Staph aureus

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18
Q

Common organisms in HAP

A
Gram negative enterobacteria
S. aureus
Pseudomonas aureginosa
Klebsiella
Clostridium
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19
Q

Symptoms of a silent MI

A
Syncope
Pulmonary oedema/ SOB
Epigastric pain
Vomiting
Acute confusion
Feeling of impending doom
Common in Elderly and diabetics
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20
Q

ECG changes in NSTEMI

A

ST depression
T wave inversion
No changes

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21
Q

Hyperacute changes in a STEMI

A

Tall T waves

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22
Q

Changes seen in a STEMI after hours (and the criteria for pPCI)?

A
ST elevation in 2 consanguineous leads
- 2mm in chest leads
- 1mm in limb leads
New LBBB
No evidence of a pathological Q wave
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23
Q

Latent ECG changes in a STEMI

A

T wave inversion

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24
Q

Contraindications to fibrinolysis

A
Previous intracranial haemorrhage
Ischaemic stroke in last 6 months
Cerebral malignancy
Recent trauma or surgery in 3 weeks
GI bleed in previous month
Bleeding disorder
Aortic dissection
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25
Classification of Aortic Dissection
Type A- Affects the ascending aorta | Type B- affects other portion of aorta
26
Signs and symptoms of aortic dissection
Central retrosternal chest pain - 'Ripping' - Radiates to back - Worst at onset then gradually improves Hemiplegia/ diplegia if carotid involvement Limb ischaemia Angina Pulse deficit
27
Best imaging type for Aortic dissection
MRI
28
Management of aortic dissection
BP aim for 100-120 mmHg Cross match 10 units of blood Surgical (stents, grafts, arch replacement) TEVAR for type B
29
Irregular features/ unstable in tachycardia warranting 3x DC shock followed by Amiodarone?
``` Hypotension/ shock Syncope HR >200BPM MI Heart failure Impaired consciousness ```
30
Examples of focal Narrow complex tachycardias
Sinus Tachycardia (underlying cause) Atrial tachycardia Junctional tachycardia Multifocal atrial tachycardia
31
Condition in which Multifocal atrial tachycardias are common?
COPD
32
Examples of Re-entrant Narrow Complex Tachycardias
Atrial Flutter Atrial Fibrillation AV Node re-entry tachycardia Atrio-Ventricular Re-entrant tachycardia
33
Management of Narrow complex tachycardia with IRREGULAR Rhythm
(Treat as Atrial Fibrillation) Rate control with beta blocker or Diltiazem ± Digoxin or amiodarone if heart failure LMW Heparin until full assessment of emboli risk ahs been made
34
Management of Narrow complex tachycardia with REGULAR rhythm
Vagal manoeuvres e.g. Valsalva, Carotid sinus massage Adenosine 6mg rapid IV bolus Followed by 2x12mg IV boluses if unsuccessful
35
Types of Broad complex tachycardia
``` Monomorphic (most common) Fascicular tachycardia RV outflow tract tachycardia Polymorphic tachycardia Torsade de pointes tachycardia ```
36
Management of Broad complex tachycardia with REGULAR rhythm
Amiodarone 300mg IV then 900mg/24h infusion
37
Management of Broad complex tachycardia with IRREGULAR rhythm
Depends on cause | - Torsade de pointes --> MgSO4 infusion 2g over 10 mins
38
Causes of bradyarrythmia/ complete heart block
Drugs (CCBs, Beta blockers, Digoxin) Lenegre's/ Lev's disease Severe hyperkalaemia
39
Management of bradyarrythmia with adverse features
Atropine 500mcg infusion every 3-5 minutes up to a maximum of 3mg Percutaneous pacing/ pacemaker more definitive
40
Causes of VF
``` MI Cardiomyopathy aortic stenosis/ dissection myocarditis tamponade trauma Brudaga syndrome Tension pneumothorax PE Primary pulmonary hypertension QT Prolonging drugs Seizures Stroke Hyperkalaemia Sepsis Drowning Electrical shocks ```
41
Management of Ventricular Fibrillation
NON-Synchronised DC shock
42
Infective causes of pericarditis
Viral (Coxsackie virus, Echovirus, EBV, influenza, HIV) | Bacterial (staph, H. influenzae, TB, meningococcus, Rheumatic fever)
43
Other causes of pericarditis
``` Sarcoidosis SLE RA Vasculitis Myxoedema Uraemia Dressler's syndrome Radiotherapy ```
44
ECG findings of pericarditis
``` ST elevation (saddle-shaped) T wave inversion ```
45
Management of pericarditis
Ibuprofen or Naproxen 250mg QDS Colchicine if symptoms persist for 14 days Treat underlying cause ± steroids
46
AAA criteria for diagnosis
Dilation of the aorta of over 50% (usually 3cm original size)
47
Risk factors for AAA
``` Male (3x) Over 65 Smoking Hypertension COPD Alcohol Infective (Brucellosis, Salmonellosis, TB, HIV) Behcet's Disease Takayasu's Disease Marfan's Syndrome Ehlers-Danlos Syndrome ```
48
Criteria for surgical repair of AAA
Over 5.5cm in size May be an open repair or endovascular (EVAR)
49
What percentage of appendicitis have perforated at presentation?
30%
50
What is Rovsing's Sign in Appendicitis?
Pain is greater in the RIF when pressing the LIF
51
What is the Cope Sign in appendicitis?
Indicates a low appendix Pain on flexion and internal rotation of the right hip
52
What indicates a retroperitoneal appendix?
Tenderness on the right on PR RUQ and flank pain
53
Choice of antibiotics for Appendicitis?
Cefuroxime and Metronidazole pre-operatively
54
Biliary Colic presentation
RUQ pain radiating interscapularly Nausea and vomiting Intermittent jaundice Lasts 15 mins to 24 hours
55
Biliary colic investigations
USS scan Bloods unremarkable ERCP/ CT/ MRI scans
56
Acute Cholecystitis presentation
``` RUQ pain radiating interscapularly Fever Local Peritonism (Murphy's Sign- pain when pressing right costal margin) ``` Nausea and vomiting Intermittent jaundice
57
Acute cholecystitis investigation findings
USS scan Bloods- mildly deranged LFTs, raised WCC/CRP ERCP/ CT/ MRI scans
58
Cholangitis presentation
CHARCOT'S TRIAD RUQ pain radiating interscapularly Fever Jaundice Local Peritonism (Murphy's Sign- pain when pressing right costal margin)
59
Cholangitis investigations findings
USS scan Bloods- Raised WCC, CRP, ALP, GGT, Bilirubin ERCP/ CT/ MRI scans
60
Risk factors for paralytic ileus
``` Surgery Pancreatitis Spinal injury Hypokalaemia Hyponatraemia Uraemia Peritoneal sepsis Drugs (TCAs) ```
61
AXR findings in small bowel obstruction
Distended loops of small bowel Valvukae conniventes completely cross the lumen
62
AXR findings in large bowel obstruction
Haustra do not cross the bowel lumen Coffee bean sign in sigmoid volvulus
63
Most common location of a diverticulum in adults
Sigmoid colon
64
Presentation of diverticulitis
LLQ colicky pain relieved on defaecation Tenderness and peritonism Fever Sudden painless bleeding
65
Cullen's sign in pancreatitis
Periumbilical bruising
66
Grey-Turner's Sign in pancreatitis
Flank bruising
67
Serum enzyme measurements in pancreatitis
Amylase (usually increases 3x/ 1000u/mL; but may be normal even in severe disease) Lipase (more sensitive and specific)
68
GET SMASHED acronym for causes of Pancreatitis
Gallstones ETOH Trauma ``` Steroids Mumps Auto-immune Scorpion Venom Hyperlipidaemia, Hypothermia, hypocalcaemia ERCP and emboli Drugs ``` And pregnancy or cancer!
69
Glasgow Prognostic Score for pancreatitis
A score of 3 or more (1 point for each) would prompt immediate ITU/ HDU referral ``` PaO2: <8KPa Age 55+ Neutrophilia (WCC >15x10^9/L) Calcium (<2mmol/L) Renal function (Urea 16mmol/L +) Enzymes (raised AST, LDH) Albumin ( <32g/L) Sugar (BM 10+) ```
70
Where are most peptic ulcers located?
Duodenal (80%)
71
ALARMS symptoms in dyspepsia- indications for an Upper GI endoscopy
Over 55 and new dyspepsia fro 4-6 weeks, with: - Anaemia - Loss of weight - Anorexia - Recent onset/ progressive symptoms - Melaena/ haematemesis - Swallowing difficulties
72
Use of the Rockall score in Upper GI bleeding
Aims to identify patients at risk of adverse events following acute upper GI bleeding. Should be interpreted with a NEWS score Under 3: Good prognosis 8+: High risk of mortality
73
Domains of the Rockall score
``` Age Shock Co-Morbidities Diagnosis Stigmata of haemorrhage on endoscopy ```
74
Presentations of Renal colic
Typical: Loin to groin spasms and inability to lie still; nausea and vomiting Upper obstruction- pain between rib 12 and lateral lumbar muscles Mid Ureteric obstruction- mimics appendicitis/ diverticulitis Lower ureteric obstruction- bladder irritability, genital pain
75
Treatment of an uncomplicated lower UTI
Nitrofurantoin 50mg/6h PO or Trimethoprim 200mg/12h PO 3 day course for women 7 day course for men
76
Treatment of Pyelonephritis
- Oral Ciprofloxacin 7-10 days IV followed by oral switch | - Cefalexin, Co-Amoxiclav are alternatives
77
Indications for inpatient treatment for Pyelonephritis
Dehydrated/ unable to tolerate oral fluids Pregnant High risk of complication development e.g. patients with structural renal disease Diabetes or immunosuppression
78
Indications for early brain imaging in stroke
``` Indications for thrombolysis/ early anticoagulation Patient on anticoagulation treatment Known bleeding tendency Reduced GCS (<13) Unexplained progressive or fluctuating symptoms Papilloedema Neck stiffness Fever Severe headache at stroke onset ```
79
Contra-Indications for Thrombolysis in stroke
``` U18 recent stroke/trauma/surgery/MI/GI bleed INR>1.7 on Warfarin Pregnancy Diabetes liver disease cancer ```
80
Bamford stroke classification of a LACS
One of: Pure sensory stroke Pure motor stroke Senori-motor stroke Ataxic hemiparesis
81
Bamford stroke classification of a POCS
Cranial nerve palsy and a contralateral motor/sensory deficit Bilateral motor/sensory deficit Conjugate eye movement disorder (e.g. horizontal gaze palsy) Cerebellar dysfunction (e.g. vertigo, nystagmus, ataxia) Isolated homonymous hemianopia
82
Bamford Stroke classification of a TACS/ PACS
``` Unilateral weakness (and/or sensory deficit) of the face, arm and leg Homonymous hemianopia Higher cerebral dysfunction (dysphasia, visuospatial disorder) ``` All 3 for TACS 2/3 for PACS
83
Blood sugar control target in acute stroke
4-11mmol/L
84
What percentage of strokes are preceded by TIAs?
15%
85
Management of a TIA with an ABCD2 score of 4+
Immediate Aspirin 300mg OD ± Clopidogrel or Dipyridamole 24 Hour referral for TIA clinic (MRI, Carotid USS) Don't drive for 1 month
86
Management of a TIA with an ABCD2 score of less than 3
Immediate Aspirin 300mg OD Specialist referral within 1 week
87
Symptoms that may precede a Vasovagal Syncope
Nausea Pallor Sweating Closing of visual fields
88
Rule of 15s for Syncope
``` Pulmonary Embolism Aortic Dissection ACS Ectopic Pregnancy Subarachnoid Haemorrhage Ruptured AAA ```
89
Prevention of syncope
Lying down/ squatting if warning symptoms Tilt training Isometric counterpressure manoeuvres (leg crossing or arm tensing) Cardiac pacing Avoid alcohol and stop drugs Increase oral fluid intake
90
Empirical antibiotic treatment of meningitis in 3 months - 50 years
IV Cefotaxime/ Ceftriaxone
91
Empirical antibiotic treatment of meningitis in 50+ years
IV Cefotaxime/ Ceftriaxone + Amoxicillin
92
Whipple's Triad of Hypoglycaemia
1. Plasma Hypoglycaemia (< 3 mmol/L; or 4mmol/L in hospital patients) 2. Symptoms attributable to low blood sugar 3. Resolution of symptoms with correction of hypoglycaemia
93
Most common site of an intracranial venous thrombosis
Sagittal sinus (50% cases)
94
Blood glucose level in DKA
11mmol/L +
95
Ketonaemia in DKA
3mmol/L in blood Ketones 2++ in urine Ketonuria does not always = ketoacidosis
96
Acidosis in DKA
Venous pH <7.3 OR Venous Bicarbonate < 15mmol/L
97
Insulin infusion rate in DKA
0.1 units/kg/hour (1 unit/mL) Initially 50ml made up of Insulin Actrapid
98
Initial Fluid in DKA if BP >90
1L Saline
99
When is glucose added to IV fluids in DKA
10% Glucose at 125ml/hr is added when BM is < 14 mmol/L
100
How to estimate serum osmolality
2Na + Glucose + Urea
101
Investigations if DVT Wells Score 2+
Proximal Leg Vein USS within 4 hours If negative, D-Dimer
102
Investigations if DVT Wells Score 1 or less
D-Dimer test If positive, Proximal Leg Vein USS
103
Duration of warfarin treatment after a DVT
3-6 months, particularly if unprovoked
104
6P's of Acute Limb Ischaemia
``` Pale Pulseless Pain Paraesthesia Paralysis Perishingly cold ```
105
What ABPI indicates critical limb ischaemia
Less than 0.5
106
Which metabolite of paracetamol is Hepatotoxic
NAPQI (5%)
107
Which enzyme normally converts the toxic metabolite of Paracetamol to a conjugate excretable in urine?
Glutathione Body has an 8 hour supply of Glutathione
108
How is N-Acetylcysteine administered as a treatment for Paracetamol OD?
Infused over 1 hour in 5% glucose. Must be commenced within 8 hours
109
SEs of N-Acetylcysteine
Erythema, urticaria, angioedema, bronchospasm
110
Alternative to N-Acetylcysteine
Methionine
111
Anticholinergic SEs of TCA (or Atropine) OD
Dry mouth, urinary retention, dilated pupils, agitation
112
Overdose with which drug may require treatment of arrhythmias with Sodium Bicarbonate
TCAs
113
Most common cause of Cellulitis (organism)
Strep pyogenes
114
What may suggest a diagnosis of septic arthritis from blood tests?
Polymorphonuclear cells >75%
115
Antibiotics for tonsillitis
``` Penicillin V (Phenoxymethylbenicillin) 10 days or clarithromcyin ``` Centor 3+
116
Most common position of leg in hip fracture
External rotation Adduction Shortening of leg
117
Common XR finding in hip fracture
Loss of shenton's Line (arc around femur and pubic tubercle)
118
Ligaments affected in medial ankle sprain
Deltoid Ligament
119
Ligaments affected in lateral ankle sprain
Calcaneofibular ligament Anterior talofibular ligament Anterior/ Posterior Inferior talofibular ligaments
120
Ligaments affected in syndesmotic ankle sprain
Interosseus and lower tibiofibular ligaments
121
Grading of ankle sprains
- Grade 1- Stretched ligament with microscopic tearing - Grade 2- Ligament stretched with partial tearing - Grade 3- Ligament is completely ruptured, severe swelling
122
Colle's versus Smith's Fractures
Colle's: Distal radius fragment displaced dorsally Smith's: Distal radius fragment displaced ventrally
123
XR Findings in anterior shoulder dislocation
Humeral head under coracoid process (AP) | Head anterior to glenoid process
124
XR Findings in posterior shoulder dislocation
Lightbulb sign | Humeral head posterior to glenoid process
125
Drugs which may cause acute urinary retention
``` Anticholinergics Opioids Benzodiazepines NSAIDs CCBs Detrusor relaxants Alcohol Antihistamines ```
126
Reversible causes of VF (4H's, 4T's)
Hypoxia Hyper/hypokalaemia Hypovolaemia Hypothermia Tamponade Tension Pneumothorax Thromboembolism Toxin
127
Reasons to consider admission for acute AF
Pulse above 150 BP <90 Chest pain/ LOC/ acute SOB Stroke/ TIA/ Acute HF
128
How often is Adrenaline given in cardiac arrest
After 3 shocks Then every 3-5 minutes
129
How often is Amiodarone given in cardiac arrest/ ALS
After 3 shocks Another after 5
130
How many posterior ribs on a CXR can indicate hyperinflation?
7
131
What is the San Francisco Syncope Rule?
Predicts adverse outcomes for patients presenting with syncope at 7 days. Any of the following classes the patient as high risk: - Congestive Heart Failure History - Haematocrit <30% - ECG Abnormalities - SOB - Systolic BP <90 at triage
132
Serious causes of ventilation compromise in trauma
``` Airway Obstruction Tension Pneumothorax Open Pneumothorax Massive Haemothorax Flail Chest Cardiac Tamponade ```
133
On the floor and four more
Visible blood loss, plus: - Chest - Abdomen - Pelvic cavity - Long Bones
134
Most common type of shock in trauma
Haemorrhagic
135
Cushing response to raised ICP
Bradycardia Hypertension Irregular respiration
136
Brainstem testing in DBD
``` Absent pupillary light reflexes Absent corneal light reflex No cranial/ limb response to pain Absent vestibulo-cochlear reflexes Absent gag/ cough reflex Apnoea test ```
137
Criteria of diagnosis for ARDS
Clinical symptoms - Acute onset - Pulmonary oedema- bilateral infiltrates on CXR - PCWP < 19mmHg (demonstrates non-cardiogenic) - Refactory hypoxaemia (pO2:FiO2 <200mmHg)
138
Key settings of control on a mechanical ventilator
``` Tidal volume/ RR Inspiratory flow I:E ratio FiO2 PEEP ```
139
Ventilating below what FiO2 reduces risk of oxygen toxicity
0.5
140
Key indications for Non-Invasive Ventilation
COPD with respiratory acidosis pH 7.25-7.35* type II respiratory failure secondary to chest wall deformity, neuromuscular disease or obstructive sleep apnoea cardiogenic pulmonary oedema unresponsive to CPAP weaning from tracheal intubation
141
Minimal daily requirements: H20
25-30 ml/kg/day
142
Minimal daily requirements: Sodium
1-2 mmol/kg/day
143
Minimal daily requirements: Potassium
0.5-1 mmol/kg/day
144
Minimal daily requirements: Glucose
50-100 g to prevent starvation ketosis | - does not cover nutritional requirements
145
What volume of blood loss produces a fall in Hb of approximately 10g/dL
500ml Significant when below 70g/dL; may be higher in elderly/ co-morbidity
146
What is in a Massive Transfusion protocol
1:1:1 Packed RBCs, FFP, Platelets Up to 10 units
147
Important drugs in renal failure
``` NSAIDs ACEi and ARBs Diuretics Contrast Medium Penicillins Metformin Statins Gentamicin ```
148
Key indications for RRT
``` Severe fluid excess e.g. Oedema Stage 3 AKI Hyperkalaemia Clearance of nephrotoxics Rising creatinine or urea ```
149
Appropriate Mannitol dose for raised ICP and SEs
Mannitol 20% solution 0.5g/kg over 20 minutes The effects only last 2-6 hours so may get a reboound rise in ICP
150
Why are patients hyperventilated in Head Injury
Reduces PaCO2: this causes cerebral vasoconstriction and reduces ICP almost immediately
151
GCS criteria warranting a 1 hour CT Head following a head injury:
GCS <13 on Initial Assessment | GCS < 15 2 hours after injury
152
1 hour CT head criteria
``` GCS <13 on Initial Assessment GCS < 15 2 hours after injury Suspected open/ depressed skull fracture Sign of basal skull fracture Post traumatic seizure Focal neurological deficit 2+ episodes of vomiting ```
153
8 hour CT head criteria
Aged 65+ Clotting/ bleeding disorder Dangerous mechanism of injury Retrograde amnesia lasting 30+ minutes
154
Signs of basal skull fracture
Haematotypanium Panda Eyes CSF leakage from ear or nose Battle Sign
155
Minimum monitoring standards for Anaesthesia
``` Cardiac (ECG) NIBP SpO2 FiO2 EtCO2 Airway Pressure (Peak Inspiratory Pressure) ```
156
When is temperature monitored in anaesthesia
For procedures lasting longer than 30 mins
157
When is a Peripheral nerve stimulator used to monitor in anaesthesia
When Akinesis (NM blockade) is performed
158
Normal level of Epidural anaesthesia
L3-L4 Can be anywhere between L1 and sacrococcygeal hiatus
159
Normal level of Spinal anaesthesia
L2-S2 Less change of cord damage with a lower level
160
Which type of Regional anaesthesia has a quicker onset of action
Spinal
161
Which vasoactive drug is avoided in obstetric anaesthesia, to reduce the risk of foetal acidosis?
Ephedrine
162
Why should an FiO2 above 0.3 be avoided in neonates
Causes proliferative retinopathy
163
Which local anaesthetics have a slow onset and duration, but a long duration of action?
Bupivicaine and Levobupivicaine
164
Types of LA and their hydrostatic properties
Esters -> Hydrophobic | Amides -> Hydrophilic
165
When can extubation occur
- When muscle paralysis has worn off - Troughs in EtCO2 monitoring - Return of cough reflex - Nerve stimulator e.g. TOF with no fade
166
How is the size of a nasopharyngeal airway assessed
Against size of patient little finger
167
Criteria to confirm correct ET tube placement
Misting of ET tube EtCO2 observed on monitor EQUAL chest expansion Auscultation of chest (confirm to air entry into stomach)
168
Cormack- Lehane Score above which you would want to use a bougie or stylet for laryngoscopy
Grade 2B+
169
Cormack- Lehane Score above which you would want to use additional devices
Grade 4
170
Angina Chest Pain: NICE definitions
1. constricting discomfort in the front of the chest, or in the neck, shoulders, jaw or arms 2. precipitated by physical exertion 3. relieved by rest or GTN in about 5 minutes All 3 features: typical angina 2 of the above features: atypical angina 0-1: Non-anginal chest pain
171
Eron Classification of Cellulitis
1: No systemic symptoms, no co-morbidities 2: Co-morbidity that may complicate treatment e.g. peripheral arterial disease, obesity 3: Significant systemic symptoms e.g. acute confusion, tachycardia, tachypnoea, hypotension, OR unstable co-morbidities, OR limb threatening infection 4: Sepsis/ necrotising fasciitis