ACUTE CORONARY SYNDROME

Question 1

MOA: venous pooling and reduces preload, cardiac workload and oxygen consumption

Answer 1

Morphine

Question 2

MOA: causes thrombus clots to be lysed

Answer 2

Fibrinolytics

Question 3

Contraindicated to active internal bleeding

Answer 3

Alteplase

Question 4

Contraindicated to active internal bleeding

Patients with impaired renal function or renal function

Answer 4

Reneplase

Question 5

Same with alteplase and reteplase (+) use with caution in pregnant patients, elderly, and sever liver function

Answer 5

Tenecteplase

Question 6

Not clearly understood but appears to inhibit the late sodium recurrent, preventing calcium overload

Answer 6

Ranolazine

Question 7

Blunting the effects of ischemia by improving myocardial function

Answer 7

Ranolazine

Question 8

Blocks the prostag;andin synthesis, which prevents formation of thromboxane A2

Answer 8

Aspirin

Question 9

Inhibit P2Y12 receptor; inhibit platelet aggregation and activation

Answer 9

P2Y Receptor Antagonist

Question 10

P2Y Receptor Antagonist Drugs

Answer 10

• Cangrelor
• Clopidogrel
• Prasugrel
• Ticagrelor

Question 11

Blockade of the glycoprotein receptor prevents fibrinogen binding, thus, inhibiting platelet aggregation, the final pathway for platelet aggregation

Answer 11

Glycoprotein 2A/3B Antagonist

Question 12

Glycoprotein 2A/3B Antagonist Drugs

Answer 12

• Abciximab
• Eptifibatide
• Tirofiban

Question 13

MOA: platelet activation is blocked through the PAR-1 receptor, the major throbbing receptor on platelets

Answer 13

PAR-1 Antagonist (Vorapaxar)

Question 14

Similar moa to UFH but molecules are smaller and have a stronger affinity to factor 10

Answer 14

LMWH(Enoxaparin)

Question 15

Direct inhibition of factor 10

Answer 15

Fondaparinux

Question 16

Direct thrombin inhibitor

Answer 16

Bivalirudin