Acute dermatology Flashcards
What drugs can cause skin reactions?
Penicillin
NSAIDs
Anti-epileptics
What can cause photo-toxic drug rash?
Quinine
Bendroflumethiazide
What can cause psoriasiform drug rash?
Lithium
Beta blockers
What can cause utricaria?
ACEi, penicillin
What is Steven Johnson syndrome?
Drug reaction presenting with vague upper respiratory symptoms 2-3 weeks after starting a drug, then painful red macules. Takes up 10% of body area.
Can be severe mucosal ulceration
What can cause SJ syndrome?
Sulphonamides
Penicillin
Anti-epileptics
NSAIDs
What is toxic epidermal necrolysis?
Like SJ, but takes up 30% of body area with widespread erythema and epidermal necrosis which can be severe in mucosa.
What can cause TEN?
Sulphonamides Penicillin Anti-epileptics NSAIDs \+ Allopurinol
How is TEN managed?
Stop causative drug
May need fluid replacement, analgesia, infection control.
What is erythema multiforme?
A hypersensitivity reaction, usually induced by HSV. Shows target lesions.
Does not progress to SJ or TEN
What is bullous pemphigoid?
Immunobullous disorder caused by IgG antibodies against the basement membrane. Seen in older people.
How does bullous pemphigoid present?
1-3cm blisters on inflamed or normal skin, can be eye involvement.
Skin biopsy shows positive immunofluoresence.
What is pemphigus?
Immunobullous disorders caused by IgG antibodies against desmosomes which leads to acantholysis. Seen in younger people.
How does pemphigus present?
Superficial blisters which burst and lead to widespread erosions.
Skin biopsy shows positive immunofluoresence.
How are immunobullous disorders treated?
Prednisolone
Azathioprine
