acute inflamm 2 Flashcards
(11 cards)
How does removal of bacterium work?
Recognition and activation Opsinisation Phagocytosis Killing Degradation
Name 4 types of receptors that aid in recognition of microbes and mediators
1) 7 alpha helical transmembrane receptors which recognises peptides, chemokines and lipid mediators.
2) Toll like receptors. Connected to CD14, LPS and microbe
3) Cytokine receptor that binds cytokines such as IFN y
4) Phagocytic receptor
What are the cellular responses of the following receptors
1) 7 alpha helical receptors
2) Toll like receptor
3) cytokine receptor
4) phagocytic receptor
1) cytoskeletal changes, signal trasnduction
2) production of mediators
3) production of mediators and production of reactive oxygen species, lysosomal enzyme
4) production of ROS, lysosomal enzymes. Phagocytosis of microbe into phagosome
Functional outcomes of cellular response and name the receptor
1) Cytoskeletal changes, signal transduction
2) Mediators
3) ROS, Lysosomal enzyme
4) Phagocytosis
1) Increased integrin activity > adhesion to endothelium
chemotaxis > migration into tissues
2) amplification of the inflammatory reaction
3) and 4) Leukocyte activation > killing of microbes
LPS endotoxin is on what?
Outer membrane of GN bacteria
LPS is composed of what?
O anitgen
Core ogliosaccharide
Lipid A
Toll like receptors or infammasome recognises what?
Associated immunostimulant
TLR4 = LPS
Opsonisation is what
coating of micorbes with host proteins, opsins.
Phagocytic receptors such as mannose receptor, what is it?
A lectin that bind glycolipids and glycoproteins that are unique to microbial cell walls
What filament assembles to form phagosome?
Actin
The phagosome formed once the microbe has been ingested undergoes fusion with what and what does this expose it to?
Fusion with membrane of a lysosomal granule which then exposes the ingested particle to destructive process.
O2 superoxide present and O2 independent
