Acute Inflammatory Dermatoses - Westra Flashcards Preview

Skin and Musculoskeletal - Week 3 > Acute Inflammatory Dermatoses - Westra > Flashcards

Flashcards in Acute Inflammatory Dermatoses - Westra Deck (14):
1

How does Urticaria present?

Transient, raised erthematous wheals
IgE and histamine mediated
Pruritic (itchy)

Often has to do with medication or some other new type of exposure

2

How does angiodema present?

Swelling of the deep dermal and subcutaneous layers
Burns + Painful
Common on eye, lip, groin, palms/soles
Laryngeal invovlement = emergency!

3

What causes angiodema and urticaria?

I Immune
A. Type I IgE Mediated
B. Auto-immune
C. Infectious
II Non-Immune
A. Physical Urticarias
B. Direct mast-cell degranulation
C. Foods containing high levels of histamine

4

What can stimulate an immune urticaria or angioedema?

Foods (shellfish/peanuts/eggs/soy/wheat/etc
Latex
Insect stings
Meds
Aeroallergens (pollens, molds, etc)

5

What are some examples of non-immune physical urticarias?

solar
cholinergic (sweating)
cold
dermographism (write on yourself)
aquagenic
Vibration
pressure

6

What are examples of stimulation of Direct Mast Cell Degranulation (NON-IMMUNE)?

Narcotics
Aspirin
NSAIDS
Radiocontrast
Dextran
ACE inhibitor
Vanco!

7

What kinds of foods have a lot of histamine?
Would this create an immune or non-immune urticaria or angioedema reaction?

Strawberries
Tomatoes
Shrimp
Lobster
Cheese
Spinach
Eggplant

IT WOULD BE NON-IMMUNE!!!!!

8

What is the general therapy for these two problems?
Dont get too crazy here people!

-Avoid the problem allergen/stimulant
-Antihistamines, esp. non-sedating H1-blockers
-Most can also improve on their own

9

What are the distinguishing traits of erythema multiform?

erythematous iris-shaped papular and vesiculobullous lesions

Generally seen in extremeties

10

3 major causes of erythema multiforme?

Drugs (mainly sulfonamides)

Infection from herpes simplex or mycoplasma

Idiopathic (big fat question mark)

***Generally the minor form is caused by Herpes Simplex, while the major and more severe form is caused be drugs reactions and mycoplasma infection

11

When do we see erythema mutliforme turn into Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis?

In both, 2 or more different mucosal membranes must be affected

Over 10% epidermal detachment becomes Stevens-Johnson
About 30% epidermal detachment considered Toxic Epidermal Necrolysis

12

What is the key feature of a fixed drug eruption?

sharply demarcated erythematous patch (could itch or burn) that heals hyperpigmented

Caused by drug

13

What is panniculitis erthema nodosum?

Erythematous tender nodules typically on anterior shins

triggered by infection, meds, or autoimmune

14

What is panniculitis erthema Induratum?

Tender erythematous nodules often seen on posterior legs

Associated with TB