Flashcards in Lyme Disease - Bakken Deck (12):
How long must a tick be attached in order to transfer the bacterial infection to the host?
36 hours (even then it's not even a sure thing)
Bacteria responsible for lyme disease?
Skin lesion indicative of lyme disease?
Erythema migrans (not all cases)
What types of symptoms do you see in early disseminated lyme disease?
Constitutional - EM lesions, lympadenopthy
Musculoskeletal - arthalgia, migratory arthritis
Neurologic - facial nerve palsy, radicular pain, poly neuritis
Cardiac - AV block
SYmptoms of late lyme disease?
Acrodermatitis chronicum atrophicans
Lab tests used most commonly for confirming diagnosis?
ELISA + EIA to check for antibodies
Problems with serologic testing?
-Often get false positives
-IgG and IgM antibodies persist for years after initial infection
-Tests poorly standardized
-Absolute titer of Ab doesnt correspond to severity of infection
What would you need to make a lyme disease diagnosis?
History of exposure to Ixodes endemic area
History of tick bite
Confirm using serology and PCR
What treatment do you use for early localized or systemic lyme disease?
What drug can be used to treat both B. Burgdorferi and A. phagocytophilum?
Doxycycline can be used to treat both
What drug should you use to treat joint CNS and Cardiac Lyme Disease?
Arthritis and CNS Lyme
-use Doxycycline or ceftriaxone