Acute Leukemias Flashcards

1
Q
  1. According to the WHO classification, except in leukemias
    with specific genetic anomalies, the minimal percentage of
    blasts necessary for a diagnosis of acute leukemia is:
    a. 10%
    b. 20%
    c. 30%
    d. 50%
A

b. 20%

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2
Q
  1. A 20-year-old patient has an elevated WBC count with 70%
    blasts, 4% neutrophils, 5% lymphocytes, and 21% monocytes in the peripheral blood. Eosinophils with dysplastic
    changes are seen in the bone marrow. AML with which of
    the following karyotypes would be most likely to be seen?
    a. AML with t(8;21)(q22;q22)
    b. AML with t(16;16)(p13;q22)
    c. AML with t(15;17)(q22;q12)
    d. AML with t(9;11)(p22;q23)
A

b. AML with t(16;16)(p13;q22)

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3
Q
  1. Which of the following would be considered a sign of
    potentially favorable prognosis in children with ALL?
    a. Hyperdiploidy
    b. Presence of CD 19 and 20
    c. Absence of trisomy 8
    d. Presence of BCR/ABL gene
A

a. Hyperdiploidy

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4
Q
  1. Signs and symptoms of cerebral infiltration with blasts are
    more commonly seen in:
    a. AML with recurrent cytogenetic abnormalities
    b. Therapy-related myeloid neoplasms
    c. AML with myelodysplasia-related changes
    d. ALL
A

d. ALL

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5
Q
  1. An oncology patient exhibiting signs of renal failure with
    seizures after initial chemotherapy may potentially develop:
    a. Hyperleukocytosis
    b. Tumor lysis syndrome
    c. Acute leukemia secondary to chemotherapy
    d. Myelodysplasia
A

b. Tumor lysis syndrome

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6
Q
  1. Disseminated intravascular coagulation is more often seen
    in association with leukemia characterized by which of the
    following mutations?
    a. t(12;21)(p13;q22)
    b. t(9;22)(q34;q11.2)
    c. inv(16)(p13;q22)
    d. t(15;17)(q22;q12)
A

d. t(15;17)(q22;q12)

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7
Q
  1. Which of the following leukemias affects primarily children,
    is characterized by an increase in monoblasts and monocytes,
    and often is associated with gingival and skin involvement?
    a. Pre-B lymphoblastic leukemia
    b. Pure erythroid leukemia
    c. AML with t(9;11)(p22;q23)
    d. AML with t(15;17)(q22;q12)
A

c. AML with t(9;11)(p22;q23)

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8
Q
  1. A 20-year-old patient presents with fatigue, pallor, easy
    bruising, and swollen gums. Bone marrow examination reveals 82% cells with delicate chromatin and prominent
    nucleoli that are CD141, CD41, CD11b1, and CD361.
    Which of the following acute leukemias is likely?
    a. Minimally differentiated leukemia
    b. Leukemia of ambiguous lineage
    c. Acute monoblastic/monocytic leukemia
    d. Acute megakaryoblastic leukemia
A

c. Acute monoblastic/monocytic leukemia

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9
Q
  1. Pure erythroid leukemia is a disorder involving:
    a. Pronormoblasts only
    b. Pronormoblasts and basophilic normoblasts
    c. All forms of developing RBC precursors
    d. Equal numbers of pronormoblasts and myeloblasts
A

b. Pronormoblasts and basophilic normoblasts

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10
Q
  1. A patient with normal chromosomes has a WBC count of
    3.0 3 109/L and dysplasia in all cell lines. There are 60%
    blasts of varying sizes. The blasts stain positive for CD61.
    The most likely type of leukemia is:
    a. Acute lymphoblastic
    b. Acute megakaryoblastic
    c. Acute monoblastic
    d. AML with t(15;17)
A

b. Acute megakaryoblastic

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11
Q
  1. SBB stains which of the following component of cells?
    a. Glycogen
    b. Lipids
    c. Structural proteins
    d. Enzymes
A

b. Lipids

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12
Q
  1. The cytochemical stain a-naphthyl butyrate is a nonspecific esterase stain that shows diffuse positivity in cells of
    which lineage?
    a. Erythroid
    b. Monocytic
    c. Granulocytic
    d. Lymphoid
A

b. Monocytic

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