Acute Phase Reactants

Question 1

C-reactive Protein

Answer 1

Increase during inflammation, produced by liver, induced by IL-6

• unregulated
• Opsonin, fixes complement and facilitates phagocytosis
• Measured clinically as a sign of inflammation

Question 2

Ferritin

Answer 2

Upregulated during inflammation, produced by liver, induced by IL-6
-Binds and sequesters iron to inhibit microbial iron scavenging

Question 3

Fibrinogen

Answer 3

Unregulated during inflammation, produced by liver, induced by IL-6

• Coagulation factor
• Promotes endothelial repair
• Correlates with ESR

Question 4

Hepcidin

Answer 4

Upregulated during inflammation, produced by liver, induced by IL-6
-Decreases iron absorption (by degrading ferroportin) and decreasing iron release (from MP) –> anemia of chronic disease

Question 5

Serum amyloid A

Answer 5

Upregulated during inflammation, produced by liver, induced by IL-6
-Prolonged elevation can lead to Amyloidosis

Question 6

Albumin

Answer 6

Downregulated during inflammation, produced by liver, induced by IL-6
-Reduction conserved amino acids for upregulated (positive) reactants

Question 7

Transferrin

Answer 7

Downregulated during inflammation, produced by liver, induced by IL-6
-internalized by MP to sequester iron