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IMMUNO SERO - review > ADAPTIVE IMMUNITY > Flashcards

ADAPTIVE IMMUNITY Flashcards

(75 cards)

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1
Q

Goal of adaptive immunity

A

Antibody production

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2
Q

antigen is introduced

A

Active immunity

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3
Q

antibody is introduced

A

Passive immunity

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4
Q

infection, natural exposure

A

Natural active

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5
Q

vaccination

A

Articial active

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6
Q

mother to fetus

A

natural passive

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7
Q

injection of artificial sera/antibody

A

artificial passive

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8
Q

yellowish milk from mother

A

Colostrum

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9
Q

2 types of adaptive immunity

A
  1. Humoral branch

2. Cellular branch

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10
Q

Cellular branch

A
  • T lymphocytes

- viral and fungal infections

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11
Q

Humoral branch

A
  • B lymphocytes

- primary defense against bacterial infection

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12
Q

lymphocyte not involved in adaptive immunity

A

NK Cells

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13
Q

not an end cell

A

lymphocyte

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14
Q

site of maturation of T cell

A

thymus

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15
Q

site of maturation of B cell

A

Bone marrow

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16
Q

site for antigen dependent lymphopoiesis

A

Secondary lymphoid organs

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17
Q

site of spleen that contains mainly of T cells only

A

PALS (Periarteriolar lymphoid sheaths

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18
Q

antigen independent lymphopoiesis

A

Bone marrow

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19
Q

thymocytes

A

immature T cells

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20
Q

site of lymph nodes that contains mainly of t cells

A

Paracortex

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21
Q

site of B cells in lymph nodes

A

Follicles & germinal centers

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22
Q

MALT

A

Mucocutaneous Associated Lymphoid Tissue

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23
Q

CALT

A

Cutaneous Associated Lymphoid Tissue

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24
Q

represents 60 to 80% of circulating lymphocytes in the peripheral blood

A

T Lymphocytes

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25
NORMAL Ratio of CD 4+: CD 8+ cells
2:1
26
in HIV, ratio of CD 4+ : CD 8+ cells
1:2 or 0.5:1
27
AIDS CD 4+ cell count
< 200 cells /uL
28
receptor for MHC Class II molecules
CD 4
29
receptor for MHC Class I
CD 8
30
Part of T cell antigen-receptor complex
CD 3
31
sheep red blood cell receptor , classical T cell surface marker
CD 2
32
Normal CD 4 count
500 to 1,300 cells/uL
33
Double negative thymocytes
Lack CD 4 and CD 8 markers
34
express both CD 4 & CD 8
Double positive thymocytes
35
stage of T lymphocyte capable of producing cytokines / lymphokines
Sensitized T cells
36
T cells with CD 25
Activated T cells
37
lacks CD 4, CD 8, & CD 3
triple negative thymocytes
38
lacks CD 4, CD 8, & CD 3 that are immature T cells
triple negative thymocytes
39
20- 35 % of lymphocytes in preipheral blood
B cells
40
functions of B cells
1. Ab production | 2. Ag presentation
41
rearrangement of genes on chromosome 14 w/c codes for the heavy chain part of the antibody molecule
Pro- B cells
42
chromosome 2 & 22
light chain
43
immature B cells Ab
IgM
44
mature B cells Ab
IgM | IgD
45
CARTWHEEL NUCLEUS
Plasma cells
46
formation of another blast
Blastogenesis
47
B cell markers
CD 19 & CD21
48
T cell markers
CD 3, CD3, CD4, CD8
49
marker for Pre-B CALLA (Common acute lymphoblastic leukemia)
CD10
50
receptor of EBV
CD21
51
+CD16, 56, 94
NK cells
52
most frequently used method for obtaining lymphocytes is density gradient centrifugation with _____
Ficoll-Hypaque
53
cell flow cytometry uses
optical light scatter
54
forward light angle
cell size
55
side/ orthogonal scatter
cell granularity
56
forward high LS
REFRACTIVE INDEX OF CELLULAR COMPONENTS
57
forward low LS
size or volume
58
Rosette technique is for
T cells
59
substances that stimulate cell division
Mitogens
60
kind of mitogen that stimulates both T cell & B cells
pokeweed
61
5-10% of total lymphocyte population
3rd population/ Natural Killer cell
62
once NK cells are activated by IL-2 they are now called
LGL (Large Granular Lymphocytes)
63
refers to substance that reacts with Ab or sensitized T cells but may not be evoke an immune response in the 1st place
Antigens
64
refers to substance that is capable of inducing immune response
Immunogens
65
MW of immunogen
10,000 Daltons
66
most immunogenic composition
Protein
67
key portion of immunogen or determinant site
Epitope
68
part of antibody that binds to the epitope
paratope or Fab
69
not immnogenic alone but if added with carrier becomes immunogenic
Haptens
70
common examples of haptens
Drugs and therapeutic hormones
71
enhance immune response
Adjuvants
72
MHC found on short arm of chromosome
6
73
MHC definition
proteins found on surface of cells
74
MHC class III examples
1. complement proteins such as C4a, C4b, and C2 | 2. Cytokines such as TNF-alpha
75
chain structure of MHC Class I
Alpha chain & | B2 microglobulin

IMMUNO SERO - review (4 decks)

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