Addiction Flashcards
1 unit of alcohol = how many ml?
10
guidelines for alcohol consumption
< 14 units per week spread over 3 days or more
what does carb deficient transferrin identify
men drinking 5 + units per day for at least 1 year
what happens to glutamate and GABA in alcohol withdrawal
excess glutamate
decreased GABA
what is glutamate toxic to
nerve cells
how does delirium tremens often present
insidious onset with night time confusion
delirium tremens > promo transfer to ?
GMW
management of alcohol withdrawal
diazepam
parenteral thiamine to prevent Wernicke’s encephalopathy
Wernicke’s encephalopathy triad
ophthalmoplegia (most commonly lateral nystagmus
ataxia
confusion
what does the prefrontal cortex do
makes sound decisions
puts ‘brakes’ on the reward pathway
addiction - increased or decreased D2 receptors
decreased
what part of the brain controls habit learning
striatum
do genetic factors play a role in addiction risk?
yes, 40-60% of risk is genetic factors!
what drug reduces ward from alcohol
drug class?
naltrexone
opiod antagonist
what drug produces acute sensitivity to alcohol
disulfiram
