ADENOVIRIDAE

Question 1

Naked icosahedral capsid, linear double stranded DNA
• ~____ size
• First isolated from cultures of human ___ and __ in the __
• Stable and viable for about ___ at___ but inactivated at ___.

Answer 1

Adenoviridae
- 70-90nm
- adenoids and tonsils
-1950
- a week at 37°C
- 50°C

Question 2

Adenoviridae Resistant to ___ and __
• Tropism: ___

Answer 2

• ether and bile salts
• nucleus of epithelial cells

Question 3

Adenoviridae Genus:
1
2

Answer 3

• Mastadenovirus-causes human infection
• Aviadenovirus-infects birds

Question 4

__ of human adenovirus divided into ____
• Commonly causes ___ and ___ but is also associated with __, ___,___ for
immunocompromised patients
• MOT: __, __,___

Answer 4

• 85 serotypes
• seven species (A through G)
• respiratory and gastrointestinal disease
• conjunctivitis, keratitis and disseminated multi-organ disease
• respiratory droplets, fecal-oral route,
  fomites

Question 5

__ of human adenovirus divided into ____
• Commonly causes ___ and ___ but is also associated with __, ___,___ for
immunocompromised patients
• MOT: __, __,___

Answer 5

• 85 serotypes
• seven species (A through G)
• respiratory and gastrointestinal disease
• conjunctivitis, keratitis and disseminated multi-organ disease
• respiratory droplets, fecal-oral route,
  fomites

Question 6

Adenoviridae Incubation period:
___- Respiratory infection
___ - gastroenteritis

Answer 6

2-14 days
3-10 days

Question 7

Adenovirus Group A

Answer 7

Serotype 12, 18, 21

Question 8

Adenovirus Group B

Answer 8

Serotype 3,7,11,14, 16,21,34,35

Question 9

Adenovirus Group C

Answer 9

Serotype 1, 2, 5, 6

Question 10

Adenovirus Group D

Answer 10

Serotype 8-10, 13, 15, 17, 19,20, 22-30, 32, 33, 36-39, 42-47

Question 11

Adenovirus Group D

Answer 11

Serotype 8-10, 13, 15, 17, 19,20, 22-30, 32, 33, 36-39, 42-47

Question 12

Adenovirus Group E

Answer 12

Serotype 4

Question 13

Adenovirus Group E

Answer 13

Serotype 4

Question 14

Adenovirus Group F

Answer 14

Serotype 40, 41

Question 15

Acute febrile Pharyngitis
Epidemic
Endemic

Answer 15

Infants young children 3,4,7
Infants young children 1,2,5,6

Question 16

Pneumonia

Answer 16

Infants
1,2,3,7

Question 17

Acute Respiratory dse

Answer 17

Military recruits
4,7,14,21

Question 18

Pharyngoconjunctival fever

Answer 18

Older school age children
3,7

Question 19

Epidemic keratoconjunctivitis (ship yard eye)

Answer 19

Adults
8,19,37

Question 20

Follicular (swimming pool) conjunctivitis

Answer 20

Any age
3,4,11

Question 21

Diarrhea and vomiting

Answer 21

Infants, young children
40,41

Question 22

Intussusception

Answer 22

Infants
1,2,5

Question 23

Hemorrhagic cystitis

Answer 23

Infants, young children
11,21

Question 24

Disseminated infection

Answer 24

Immunocompromised e.g AIDS, renal, bone marrow and heart lung transplant recipients
5,11,34,35,43-47

Question 25

Respiratory Diseases

Answer 25

Pharyngitis Pneumonia Acute respiratory dse

Question 26

: the major cause of nonbacterial pharyngitis and tonsillitis, presenting as febrile common cold. • Types ___ are commonly responsible

Answer 26

Pharyngitis - 1-7

Question 27

___ and ___ are associated in adults resembling primary ____ • particularly types __,___, and __ are thought to be responsible for about 10–20% in childhood. • In infants and young children type ___ may lead to more serious and even fatal.

Answer 27

- Adenovirus types 3 and 7 - atypical pneumonia - 3, 7, and 21 -7

Question 28

the cause among military recruits. • Serotypes __, ___ and __ are the agents commonly isolated

Answer 28

Acute respiratory dse - 4, 7 and 21

Question 29

Eye infections

Answer 29

Pharyngoconjunctival fever Epidemic keratoconjunctivitis (EKC) Acute follicular conjunctivitis

Question 30

: tends to occur in outbreaks, such as at children’s summer camps (swimming pool conjunctivitis), and is associated with serotypes __,___,__

Answer 30

Pharyngoconjunctival fever - 3, 7 and 14

Question 31

a serious condition which may appear as an epidemics, usually caused by type __ and less often by types __ and __. • Occurs mainly in adults and is highly contagious

Answer 31

Epidemic keratoconjunctivitis EKC - 8 - 19 and 37

Question 32

: Types __ __ and ___ are commonly responsible. • Adenoviral and chlamydial conjunctivitis are clinically similar.

Answer 32

Acute follicular conjunctivitis - 3,4,11

Question 33

Gastrointestinal Disease : Some fastidious adenoviruses can cause this in children serotypes __ and __

Answer 33

Diarrhea 40 and 41

Question 34

Systemic Infection Adenovirus 1 2

Answer 34

1 Meningitis (serotype 3 and 7) 2 Adenovirus infection in immunocompromised patients ➢ SCID-pneumonia and hepatitis ➢ AIDS-latent kidney infections (urine), subgenus D seen in stool ➢ Bone marrow transplant recipients

Question 35

Treatment and Prevention of Adenovirus • No specific antiviral chemotherapy (supportive care only) • For swimming pool-associated conjunctivitis- ___ • Vaccine: ___

Answer 35

- adequate levels of chlorine in water - Non-attenuated live Adenovirus types 4, 7, and 21 packaged in enteric capsules (military only)

Question 36

• Members of Parvoviridae • Dependent with __ or ___ to provide missing functions

Answer 36

AAVs (Adenovirus Associated Viruses) - Adenoviruses or Herpes Simplex Virus