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Endocrine Disorders > Adrenal > Flashcards

Flashcards in Adrenal Deck (9)
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1

Invx for Cushing

24hr urinary free coritisol
ACTH -?ACTH dependent
Can’t use DXM
MRI if found

2

Management in preg- Cushing

Control HTN and DM
Unilateral adrenalectomy 2nd trimester if indicated
Pituitary- 2nd trimester if indicated
If surgery- must replace cortisol with cortisone

3

Adrenal insuffienciency

Primary - high ACTH; addisons; adrenal origin
Secondary- from hypothalamus or pituitary, Low ACTH, usually post treatment with glucocorticoid

4

Acute adrenal crisis

Shock
Hypotension
Hypoglycemia
Hyponatraemia
Hyperkalamia

5

Phaeochromocytoma

90% arise in adrenal gland
3-36% metastatic
Some germline mutation

6

Phaeochrom features

HTN
Plasma metanephrines
Proteinuria

Usually hard to distinguish from PET

7

Conn’s syndrome

HTN
Hypokalamaeia

8

CAH

AR
Serum 17OH progesterone accumulates
Need cortisone replacement
More prevelant in Akanashi Jews

9

Clinical features of Addison’s disease

Weight loss
Poor wellbeing
Vomiting
Lethargy
Postural hypotension
Hyperpigmentation
Hyponatraemia
Hyperkalaemia
Hypoglycaemia