Adrenal Disorders Flashcards
What is addision disease
This is the failure of adrenal cortices to produce adrenocortical hormones
Autoimmunity against cortices occurs in
80% of Addison diseases
What are the causes of hypoadrenalism
Primary atrophy
Autoimmunity
Tuberculosis destruction of adrenal gland
What is the effect of hypoadrenalism on mineralocorticiod effect
Loss of sodium ions and ions—–reduced k+ ions secretion—–reduced ECF vol and plasma vol—reduced RBC conc— reduced CO —SHOCK AND DEATH
What was the duration of survival with hypoadrenalism
4days to 2 weeks
What are the features of Addison disease
Glucocorticoid , mineralocorticoid deficiency and hyperpigmention of thin skin and mucous layer
The inability to maintain normal blood glucose concentration between meals in addision deficiency is due to
Decreased gluconeogenis action of cortisol
What are the effects of glucocorticoids effect in Addison disease
Decreased gluconeogenisis
Metabolic activities depression due to decreased mobilization of fats and proteins from tissues
Muscle weakness due to low energy mobilization
Susceptibility to stress effect
The uneven deposition of melanin in Addison disease is found where
Thin mucous membrane like lip and nipple
Hyper pigmentation is due to
Depression of normal negative feedback to the hypothalamus and ant. Pituitary gland
Increased rate of ACTH as well as MSH
formation of melanin
Cushing syndrome is due to the hyper secretion of
Cortisol
Androgen
