Flashcards in Adrenal Function Deck (10)
Wher are the adrenal glands located?
The adrenal glands are located abouve the kidneys, if either adrenal gland is removed, the other will double in size.
Name the two distinct parts of the adrenal gland
1) The outer cortex
2) The inner medulla
The cortex can be further subdivided into the....
Outer cortex - Zona glomerulosa cells are fund here
Inner cortex - Zona fasciculata and Zona Reticularis cells are found here
Describe the Zona Fasciculata
Zona Fasciculata consists of steroid hormone secreting cells that make steroid hormones.
Describe the Zona Reticularis
The Zona Reticularis cells are responsible for producing androgen hormones, such as DHEA and androstenedione.
Describe the cells found in the adrenal medulla - what hormones are found here?
The cells found in the adrenal medulla contain modified ganglion cells which are similar to modified nerve cells. They look completely different to the cells in the Zona Fasciculata that produce cortisol. Noradrenaline and adrenline are found here in vesicles to stimulate the sympathetic nervous system.
Describe the histology of the cells in the adrenal glands.
Youngest - Glomerulosa matures to form the Fasciculate matures to form the Reticularis which matures to form the modified ganglion cells in the inner medulla.
State the intermediates when forming steroid hormones. For each intermediate, state the number of carbon atoms in each intermediate
Cholesterol (C27) -----> Pregnane derivatives such as progesterone, and corticoid derivatives (C21) ----> Androgens such as DHEA and androstenedione(C19) ----> Oestrogen derivatives (C18)
Describe the role of Aldosterone (ADST). Mention the site of synthesis, classification of the hormone function and the MOA
Site of synthesis: Zona Glomerulosa
Classification of the hormone: Mineralocorticoid
Function: Controls the balance of electrolytes to maintain homeostasis
MOA: ADST targets renal tubules, more K+ excreted, more Na+ reabsorbed ----> more water reabsorbed --------------> Higher BP. ADST release regulated by RAAS.