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Flashcards in Adrenal Gland Deck (33):
1

What are examples of endogenous glucocroticoids?

Cortisol
Cortisone

2

What is an example of an endogenously produced mineralocorticoid?

Aldosterone

3

Canine hyperadrenocorticism can be in three different forms:

Pituitary dependent
Adrenal dependent
Iatrogenic

4

What is the cause of pituitary dependent hyperadreoncorticism?

Autonomous secretion of ACTH from a pituitary tumor

5

What is the cause of adrenal dependent hyperadrenocorticism?

Autonomous secretion of cortisol from adrenal tumor

6

Which is more common: Pituitary dependent or adrenal dependet?

Pituitary dependent

7

What can cause iatrohenic hyperadrenocorticism?

Chronic steroid administration

8

What are some clinical signs you will see with hyperadrenocorticism?

PU/PD
Polyphagia and panting
Organomegaly
Pot belly
Generalized muscle atrophy

9

What are some lab abnormalaties associated with hyperadrenocorticism?

Increased ALP
Isosthenuria

10

What are screening tests for hyperadrenocorticism?

Baseline cortisol (POOR)
Urine cortisol:Creatinine ratio (GOOD)
ACTH Stimulation
Low dose deamethasone suppression test

11

T/F Baseline cortisol tests are very bad for diagnostics for HAC

TRUE

12

In an animal suffering from HAC, what would the UCCR be?

Elevated above reference interval

13

What response would you seen in a PD and AD-HAC dog with the ACTH stimulation test?

Post cortisol >22 ug/dL

14

What response would you see in an Iatrogenic HAC dog with the ACTH stimulation test?

No response/stimulation

15

What would the response be in an AD-HAC dog after the low dose dexamethasone test?

No suppression

16

What would be the response of a PD-HAC dog to low dose dexamethasone test?

No suppression OR partial suppression

17

What are some differentiating tests for HAC?

Endogenous ACTH
High dose dexamethasone suppression test
Imaging

18

What differences would you expect between PD-HAC and AD-HAC in the endogenous ACTH test?

AD-HAC: Decrease in ACTH

PD-HAC: WRI or increased ACTH

19

What differences would you expect between PD-HAC and AD-HAC in the HIGH dose dexmethasone suppression test?

AD-HAC: No suppression at 4 to 8 hours

PD-HAC: Suppression at 4 and possibly 8 hours

20

Pituitary pars intermedia dysfunction autonomously secretes what?

POMC

21

T/F Hirsutism alone positively predicts 90% of PPID cases

TRUE

22

What are some other clinical signs seen with PPID?

PU/PD, Muscle loss, increased adiposity, laminitis

23

What does PPID lead to the increase of?

ALpha/Beta MSH: winter effects
ACTH: Hyperadrenocorticism
Lipotropin:

24

When do you have to be careful performing diagnostic tests for PPID?

In the fall

25

What reaction would you see in a normal/stressed horse from a equine dexamethasone suppression test? PPID horse?

Normal: suppression; decrease in 19hr post cortisol

PPID: No suppression (Could also see this with a normal horse in the fall)

26

A horse with PPID tested endogenous ACTH would see what? Normal horse?

Endogenous ACTH WRI: Not PPID

Increase in ACTH: PPID or normal horse in the fall

27

What are the two forms of canine hypoadrenocorticism? Which is most common?

Decrease in glucocorticoids and mineralocorticoids due to adrenal cortical dysfunction

Primary: Autoimmune destruction of adrenal cortex

Secondary: Decrease in ACTH secretion due to pituitary lesion

28

Canine hypoadrenocorticism is also called what?

Addison's disease

29

What are some signs of hypoadrenocorticism?

It is the great pretender = incredibly vague signs

Lethargy, weight loss, dehydration, GI disease

30

What are some lab signs of hypoadrenocorticism?

Absence of stress leukogram
Na:K ratio

31

T/F 100% of hypoadrenocorticism dogs have baseline cortisol

TRUE

Perform the ACTH stim test next

32

Which test is the gold standard for diagnosing hypoadrenocorticism?

ACTH Stimulation test

33

What would you expect to see from an ACTH stimulation test in a normal dog? Hypoadrenocorticism dog?

Normal/Stressed: would get cortisol stimulation

Hypoadrenocorticism: No stimulation