Flashcards in Adrenal Gland Deck (33):
What are examples of endogenous glucocroticoids?
What is an example of an endogenously produced mineralocorticoid?
Canine hyperadrenocorticism can be in three different forms:
What is the cause of pituitary dependent hyperadreoncorticism?
Autonomous secretion of ACTH from a pituitary tumor
What is the cause of adrenal dependent hyperadrenocorticism?
Autonomous secretion of cortisol from adrenal tumor
Which is more common: Pituitary dependent or adrenal dependet?
What can cause iatrohenic hyperadrenocorticism?
Chronic steroid administration
What are some clinical signs you will see with hyperadrenocorticism?
Polyphagia and panting
Generalized muscle atrophy
What are some lab abnormalaties associated with hyperadrenocorticism?
What are screening tests for hyperadrenocorticism?
Baseline cortisol (POOR)
Urine cortisol:Creatinine ratio (GOOD)
Low dose deamethasone suppression test
T/F Baseline cortisol tests are very bad for diagnostics for HAC
In an animal suffering from HAC, what would the UCCR be?
Elevated above reference interval
What response would you seen in a PD and AD-HAC dog with the ACTH stimulation test?
Post cortisol >22 ug/dL
What response would you see in an Iatrogenic HAC dog with the ACTH stimulation test?
What would the response be in an AD-HAC dog after the low dose dexamethasone test?
What would be the response of a PD-HAC dog to low dose dexamethasone test?
No suppression OR partial suppression
What are some differentiating tests for HAC?
High dose dexamethasone suppression test
What differences would you expect between PD-HAC and AD-HAC in the endogenous ACTH test?
AD-HAC: Decrease in ACTH
PD-HAC: WRI or increased ACTH
What differences would you expect between PD-HAC and AD-HAC in the HIGH dose dexmethasone suppression test?
AD-HAC: No suppression at 4 to 8 hours
PD-HAC: Suppression at 4 and possibly 8 hours
Pituitary pars intermedia dysfunction autonomously secretes what?
T/F Hirsutism alone positively predicts 90% of PPID cases
What are some other clinical signs seen with PPID?
PU/PD, Muscle loss, increased adiposity, laminitis
What does PPID lead to the increase of?
ALpha/Beta MSH: winter effects
When do you have to be careful performing diagnostic tests for PPID?
In the fall
What reaction would you see in a normal/stressed horse from a equine dexamethasone suppression test? PPID horse?
Normal: suppression; decrease in 19hr post cortisol
PPID: No suppression (Could also see this with a normal horse in the fall)
A horse with PPID tested endogenous ACTH would see what? Normal horse?
Endogenous ACTH WRI: Not PPID
Increase in ACTH: PPID or normal horse in the fall
What are the two forms of canine hypoadrenocorticism? Which is most common?
Decrease in glucocorticoids and mineralocorticoids due to adrenal cortical dysfunction
Primary: Autoimmune destruction of adrenal cortex
Secondary: Decrease in ACTH secretion due to pituitary lesion
Canine hypoadrenocorticism is also called what?
What are some signs of hypoadrenocorticism?
It is the great pretender = incredibly vague signs
Lethargy, weight loss, dehydration, GI disease
What are some lab signs of hypoadrenocorticism?
Absence of stress leukogram
T/F 100% of hypoadrenocorticism dogs have baseline cortisol
Perform the ACTH stim test next
Which test is the gold standard for diagnosing hypoadrenocorticism?
ACTH Stimulation test