Adrenal Hormones Flashcards Preview

PHARMACOLOGY 4.0 > Adrenal Hormones > Flashcards

Flashcards in Adrenal Hormones Deck (45):
1

Adrenal suppression manifests after how long of corticosteroid therapy

> 2 weeks

1

Progestin in oral contraceptive; aldosterone antagonist

Drospirenone

2

Diagnostic test for Cushing's syndrome

Dexamethasone Suppression Test

3

1/3 of cortisol produced daily is excreted in the urine as

dihydroxyketone metabolites

4

enzyme that converts cortisol to cortisone

11-hydroxysteroid dehydrogenase

4

Potent steroid with both glucocorticoid and mineralocorticoid activity

Fludrocortisone

4

used diagnostically for detection of aldosteronism in hypokalemic patients with hypertension dosage of 400-500 mg/d for 4-8 days

Spironolactone

5

Approved for treatment of hypertension; spironolactone antagonist

Epleronone

6

Treatment for Aldosteronism

Fludrocortisone Deoxycorticosterone acetate

8

major limitation in the treatment use of glucocorticoids

Osteoporosis

8

Causes generalized glucocorticoid resistance

MIfepristone

9

What is present if 17-hydroxylation in the adrenals is defective?

Hypogonadism

9

Precursor of aldosterone, half life

Deoxycorticosterone, 70 mins

11

Half life of Cortisol

60-90 minutes

12

Excessive production of aldosterone by adrenal adenoma

Primary Aldosteronism

14

Treatment for Congenital Adrenal Hyperplasia

Oral Hydrocortisone

15

Glucocorticoid antagonists

MAKAMTM Metyrapone Aminogluthetimide Ketoconazole Abiraterone Mifepristone Trilostane Mitotane

16

a 3β-17 hydroxysteroid dehydrogenase inhibitor

Trilostane

17

Drug of choice for stimulation of lung maturation in fetus

IM Bethamethasone (mother)

18

Ketoconazole ADR

Hepatotoxic

19

Relative selective inhibitor of 11 hydroxylation, interfering with cortisol and corticosterone synthesis

Metyrapone

19

Reduces synthesis of corticosteroids in the gonads

Abiraterone

21

excreted cortisol in the urine is measured by

17-hydroxysteroids

21

Treatment of Hirsutism in women

Spironolactone (50-200mg/d)

22

Treatment for Addison's Disease

Large amount of parenteral hydrocortisone + correction of fluid and electrolyte abnormalities

22

Low suppressed levels of plasma renin activity & angiotensin II

Secondary Aldosteronism

23

what is the daily hydrocorticosteroid levels in Addison's Disease?

20-30 mg

23

Blocks 17ά-hydroxylase and 17,20-lyase

Abiraterone

26

Most commonly prescribed salt retaining hormone

Fludrocortisone

27

Used in conjunction with dexamethasone or hydrocortisone (eliminate estrogen production in breast CA)

Aminogluthetimide

28

Normal individual morning cortisol

< 3 mcg/dl

29

An orally active prodrug and has been studied in the treatment of refractory prostate cancer.

Abiraterone

30

Related to the DDT class of insecticides

Mitotane

31

Used in treatment of Primary Aldosteronism with dosage of 50-100mg/d

Spironolactone

33

large amounts of deoxycorticosterone is produced when this adrenocortical enzyme is deficient

11-hydroxylase

34

Treatment for Cushing's Syndrome

surgical removal of the tumor resection of the adrenals given with 300mg soluble hydrocortisone as continuous IV on the day of surgery

35

Block conversion of cholesterol to pregnenolone

Aminogluthetimide

36

half life of aldosterone

15 -20 minutes

38

Daily dose of 100 mg hydrocortisone or more , for > 2 weeks produces?

Iatrogenic Cushing's Syndrome

39

Potent and rather nonselective inhibitor of adrenal and gonadal steroid synthesis

Ketoconazole

40

what is the source of synthetic corticosteroids?

Cholic acid

41

Result of bilateral adrenal hyperplasia secondary to an ACTH –secreting pituitary adenoma

Cushing's syndrome

43

How to differentiate between Hypercortisolism due to anxiety and alcoholism

Dexamethasone for 2 days and then followedby CRH test

44

rare but serious acute adverse effects of high dose glucocorticoids

Acute pancreatitis

45

Mineralocorticoid antagonist

SPIRONOLACTONE