Hypothalamic and Pituitary Hormones Flashcards Preview

PHARMACOLOGY 4.0 > Hypothalamic and Pituitary Hormones > Flashcards

Flashcards in Hypothalamic and Pituitary Hormones Deck (61):
1

Alternative to Gonadotropin treatment in Male infertility

Gonadorelins

1

Antagonist for Oxytocin receptor

Atosiban

2

What is a contraindication to GH therapy?

Patient with Malignancy

2

Treatment of Leiomyomata (Fibroids)

continouos GnRH agonists + supplemental iron

2

ADR that is characterized by Serum testosterone levels increase (first 7-10 days; falls about 2 weeks) precipitate pain in patients with bone metastases, and tumor growth and neurologic symptoms

Tumor flare

2

Contraindications to Oxytocin treatment

Fetal distress abnormal fetal presentation cephalopelvic disproportion uterine rupture Prematurity

3

a disease of GH receptor insensitivity

Laron syndrome

5

ERGOT DERIVATIVE Dopamine Agonist

Bromocriptine Cabergolide

6

role of continuous GnRH and GnRH analog in COH

prevent pemature LH surge and ovulation

7

Vasopressin Antagonists

Conivaptan Tolvaptan (more V2)

8

Treatment of Choice for central precocious Puberty

GnRH analogs: Leuprolide Nafarelin Histrelin

9

Growth Hormone Antagonists

o Somatostatin o Somatotropin-Release Inhibiting Factor o Dopamine

9

Measures the fetal heart rate response to a standardized oxytocin infusion; Provides information about Placental Circulatory Reserve

Oxytocin Challenge Test

10

Advantage of GnRH antagonists over GnRH analogs

Immediate antagonist effect effects reverse more quickly

11

acetate salt of synthetic human GnRH

Gonadorelin

12

Major source of IGF-1

liver

12

hCG is produced and excreted where?

produced: placenta excreted: urine

13

Patients with Turner's who are taking GH therapy are prone to development of

Otitis media

13

3 forms of purified FSH

Urofollitropin (2) recombinant forms: Follitropin alfa Follitropin beta

14

Alternative for Ovulation induction (ex: Clomiphene has no effect)

gonadotropins

15

Treatment of severe IGF-1 deficiency that is not responsive to GH (GH-resistance syndromes)

Mecasermin

16

Peripheral antagonism of GH: decreases IGF

Pegvisomant

17

GnRH receptor antagonists:

Ganirelix Cetrorelix Abarelix Degarelix

18

Treatment for Tumor flare?

Bicalutamide

19

Menotropin that is purified (removed LH function)

Urofollitropin

20

what does it mean when Administration of GnRH has No change in baseline serum LH

Hypogonadotropic Hypogonadism or Constitutional Delay

21

human menopausal gonadotropin extracted from urine of menopausal women

Menotropins

22

Treatment for endomtriosis

continouos GnRH agonists: Leuprolide Goserelin Nafarelin (nasal spray)

23

Side effects of Pegvisomant

o Reversible liver enzyme elevation o Lipodystrophy o Injection site pain

24

early sign of GH deficiency

Hypoglycemia

25

Contraindications of GnRH Therapy

Pregnancy Lactation

26

drug that is packaged and dosed at the basis of its weight rather than its activity

Choriogonadotropin alfa (rhCG)

26

Risks of Controlled Ovarian Hyperstimulation in ART

o Multiple pregnancies o Ovarian hyperstimulation syndrome (OHSS)

27

rarely reported adverse effect of GH therapy (may manifest as vision changes, headache, nausea, or vomiting)

Intracranial hypertension (Pseudotumor Cerebri)

29

used for stimulation of follicular development in infertile women with profound LH deficiency

Lutropin alfa

31

Recombinant form of GH

Somatropin

32

hCG is virtually identical to what 3 other hormones

TSH, LH, FSH

33

stimulates the release of prostaglandins and leukotrienes that augment uterine contraction

Oxytocin

34

Mecasermin is composed of?

o rhlGF-1 (recombinant human IGF) o rhlGFBP-3 (binding protein-3)

35

Treatment regimen for prostate cancer

continouos GnRH agonists + Androgen receptor antagonist (Flutamide)

37

Treatment for Male infertility and for ART

hCG

40

Ergot-derivative Dopamine agonist with longest duration

Cabergolide

41

Functions of FSH in males and females

females: stimulates granulosa cells to convert androgens to estrogens Males: stimulates sertoli cells to convert testosterone to estrogen

42

Synthetic analogs of GnRH

 Goserelin/LHRH  Histreln  Leuprolide  Nafarelin  Triptorelin

43

Principal Function is for ovarian follicle development

FSH

44

Gonadotropins are most commonly used for what condition?

Controlled Ovarian Hyperstimulation

46

Function of LH in males and females

females: stimulates theca cells for androgen production males: stimulates leydig cells for testosterone production

47

45x more potent in inhibiting GH release (compared to Somatostatin)

Octreotide

48

DOC for acromegaly

LANREOTIDE

50

Cornerstone of Assisted Reproductive Technology

Gonadotropins (FSH, LH, hCG)

51

Treatment of Choice for Female infertility

Clomiphene

52

Stimulates longitudinal bone growth until epiphyses close near the end of puberty

IGF-1

53

Toxicity of Dopamine Agonits

Erythromelalgia Peripheral digital vasospasm Psychiatric manifestations

54

Standard medical treatment for hyperprolactinemia

Dopamine agonists

55

NON-ERGOT DERIVATIVE Dopamine Agonist

Quinagolide Pramipexole Ropinirole

56

Biphasic response to continous gonadorelin treatment

Flare (first 7-10 days) Receptor-down regulation

57

Long-acting synthetic analog of vasopressin

Desmopressin acetate

58

Treatment for Tocolysis (preterm labor)

Atosiban

59

What is the most important adverse effect of Mecasermin?

Hypoglycemia

60

Most widely used somatostatin analog

Octreotide

61

2x more potent in reducing insulin secretion (compared to Somatostatin)

Octreotide