Adrenergic Agonists

Question 1

what effect does a1 agonist have on heart?

how does this effect cardiac output?

Answer 1

constriction

dec. cardiac output

Question 2

what effect does B1 agonist have on heart?

how does this effect cardiac output?

Answer 2

dilation

inc. cardia output

Question 3

Dopamine:

at low dose it is an agonist at __ receptors and does what functions?

Answer 3

D1

increases renal vasodilation

Question 4

Dopamine:

at medium dose it is an agonist at __ receptors and does what functions?

Answer 4

B1

increases cardiac output and renin secretion

Question 5

Dopamine:

at highest dose it is an agonist at __ receptors and does what functions?

Answer 5

a1

increase BP via vasoconstriction

Question 6

Dobutamine is what drug class?

what does it do?

Answer 6

pseudo-B1 selective agonist

inc cardiac output w/o inc HR

Question 7

select all the contraindications of B2 selective agonists:

a. Pulmonary artery disease
b. diabetes
c. pregnancy
d. coronary artery disease
e. hypertension
f. parkinsons
g. hyperthyroidism
h. glaucoma

Answer 7

b,d,g,h

Question 8

terbutaline (brethine, brethaire) is what drug class?

Answer 8

SABA

Question 9

T/F Salmeterol is a partial agonist

Answer 9

true

Question 10

LABAs are always given in conjunction with?

Answer 10

steroids

Question 11

What is mirabegron used for?
what drug class is it?

Answer 11

overactive bladder

B3 selective agonist

Question 12

how do a1-selective agonists slow heart rate?
why might this be an issue?
why might this be beneficial?

Answer 12

they increase BP which activates the baroreflex to slow down HR
may cause hypertension
treat hypotension

Question 13

what drug class is midodrine?
what does it do?

Answer 13

a1 selective agonist

treats hypotension

Question 14

what drug class is phenylephrine?
what does it do?

Answer 14

a1 selective agonist

acts as a decongestant

Question 15

what do a1 sympathomimetics with a2 activity do?

whats an example drug?

Answer 15

cause vasoconstriction in nose and eyes

tetrahydrozoline

Question 16

do a1 selective agonists dilate or constrict blood vessels in the nose?

Answer 16

constrict

Question 17

how do a2-selective agonists/sympatholytics lower blood pressure?

Answer 17

inhibit NE release and block baroreflex

Question 18

Clonidine:
drug class:
use:

Answer 18

a2-selective agonist

anti-hypertensive, ADHD, opioid withdrawal

Question 19

Guanfacine
drug class:
use:

Answer 19

a2-selective agonist

ADHD, anti-anxiety, sedation

Question 20

Dexmedetomidine
drug class:
use:

Answer 20

a2-selective agonist

sedation

Question 21

Lofexidine
drug class:
use:

Answer 21

a2-selective agonist

opioid withdrawal

Question 22

Apraclonidine and Brimonidine
drug class:
use:

Answer 22

a2-selective agonist

glaucoma