Adrenergic / Cholinergic Flashcards Preview

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Flashcards in Adrenergic / Cholinergic Deck (37):
1

Tubocurarine

NMJ blocker by non-depolarization. Competitive antagonist of N AchR

2

Succinylcholine

NMJ blocker by depolarization. Agonist for N AchR. Fasciculations follow by phase 1 (depolarization), then phase 2 (desensitization). Resists Achase.

3

N AchR agonists? (2)

Acetylcholine and nicotine

4

Carbamoylcholine

N+M AchR agonist, resists AchE

5

Ganglionic blockers

N AchR antagonist

6

M AchR agonists? (3)

Muscarine, pilocarpine (salivary gland and glaucoma), and bethanechol (bladder).

7

Atropine and scopolamine

M AchR antagonists. Belladonna alkaloids.

8

Botulinum

Enters cholinergic nerve and prevents vesicle fusion.

9

Physostigmine and neostigmine

Reversible AchE blockers, physostigmine enters CNS to cure atropine poisoning

10

Parathion, malathion, sarin

Organophosphates that irreversibly inhibit AchE. Temporarily cured by atropine. Permanently cured by pralidoxime.

11

Epinephrine

Nonselective a and b agonist. At low binds b, at high binds a and b.

12

Norepinephrine

a agonist, b1 > b2.

13

Isoproterenol

b1 and b2 agonist.

14

Phenylephrine

a1 agonist. Raises blood pressure.

15

Albuterol

b2 agonist. Treats asthma.

16

Clonidine

a2 agonist. Treats hypertension.

17

MAO inhibitors

Increase norepinephrine in nerve terminals and potentiate tyramine.

18

a1 receptor

Activates Gq, PLC, DAG and IP3. Vasoconstriction and GI muscle relaxation.

19

b1 receptor

Activated Gs, cAMP increases. Increases heart contractility, rate, AV conduction, and renin release from kidneys.

20

b2 receptor

Activates Gs, cAMP decreases. Vasodilation.

21

Tyramine

Indirectly increases sympathetic by promoting norepinephrine vesicle fusion.

22

Ephedrine and Amphetamine

Indirectly activates sympathetic by increasing norepinephrine release.

23

Cocaine and tricyclic antidepressants

Inhibit norepinephrine uptake.

24

Phentolamine

a1 and a2 antagonist

25

Propranolol

b1 and b2 antagonist

26

Hydrochlorothiazide

Thiazide diuretic. Block NaCl symporter in distal tubule. Increased Na, K, Cl excretion. First drug given.

27

Furosemide

Block NKCC in TAL to increase Na, K, Cl excretion. Used for pulmonary edema and as secondary drug. Interacts with antibiotics and NSAIDS.

28

Potassium sparing diuretics

Can either act on Na channel or as aldosterone analogue antagonist.

29

Metroprolol

Blocks B1R in heart (decrease HR, contractility, and CO) and in kidney (decrease renin, A2, and TPR)

30

Alpha 2 agonists

CNS agonists to vasodilate. Very rare cases.

31

Prazosin

A1 antagonist leads to vasodilation which decreases TPR and MAP. Secondary drug.

32

Nifedipine

CCB in arterial smooth muscle. Blocks L VG Ca channel

33

Verapamil

CCB blocks calcium entry into myocytes

34

Hydralzaine

Vasodilator that activates K channels to hyperpolarize cell and prevent contraction

35

Lisinopril

ACE inhibitor and Kininase inhibitor (raises vasodilator bradykinin). All cleared by kidney and may lead to hyperkalemia. No prego, cough.

36

Losartan

At1 blocker, insurmountable competitive antagonist. Hyperkalemia. No prego.

37

Aliskiren

Direct renin competitive inhibitor. Low bioavailability. No prego. Reduces furosemide effect and increased plasma conc with glycoprotein inhibitors.