Immunology Cytokines Flashcards Preview

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Flashcards in Immunology Cytokines Deck (26):
1

TLR 1, 2, 6

Bacterial lipopeptides

2

TLR 4

Lipopolysaccharide

3

TLR 5

Bacterial flagellin

4

TLR 3, 7, 8

Viral RNA

5

TLR 9

CpG DNA

6

Bacterial TLR?

NFkB TFs TNF and IL-1, adhesion molecules, costimulators

7

Viral TLR?

Interferon regulatory factors produce T1 IFN.

8

Inflammasome

NLRP3 sensor, adaptor, Caspase 1. Active Caspase 1 cleaves inactive IL-1b, activating and secreting.

9

M1 Macrophages

Activated by microbes and IFNy. Produces ROS and NO for killing. Produces IL-1, IL-12, IL-23 for inflammation.

10

M2 Macrophages

Activated by IL-13 and IL-4. Produces IL-10 and TGFb for anti inflammation. Produces GFs and TGFb for fibrosis.

11

Tumor Necrosis Factor

Produced by Macrophages and T cells. Inflammation, fever, weight loss, neutrophil activation.

12

IL-1

Produced by Macrophages. Similar to TNF.

13

IL-6

Produced by Macrophages. Creates fever.

14

IL-8

Many cells produce, chemokine and activator for leukocytes.

15

IL-12

Produced by dendritic cells and Macrophages. Tells NK cells to produce IFNy and become cytotoxic. Causes differentiation to Th1

16

IFNy

Produced by NK cells and Th1 cells. Activates Macrophages and increases Ab response. Activates Th1 cells.

17

Type 1 IFN

Produced by Macrophages and fibroblasts. Increases antiviral state and activates NK cells.

18

IL-10

Produced by Macrophages, NK cells, and Th2 cells. Suppresses immune system (M1 Macrophage).

19

IL-2

T cell growth factor

20

IL-4

Th2 growth factor. Targets B cells for IgE secretion. Increases gut secretion and peristalsis. Inhibits M2 macrophage

21

IL-5

Eosinophil activator produces by Th2 cells.

22

IL-13

Gut secretion and peristalsis produced by Th2 cells. M2 macrophage

23

IL-17

Produced by Th17 cell. Activates leukocytes (neutrophils) and causes release of IL-1, IL-6, and TNF. Causes psoriasis.

24

IL-23 and TGFb

Th17 growth factor

25

IL-22

Produced by Th17 cells to decrease barrier permeability.

26

Mycobacterium

Inhibits phagolysosome fusion.