Adrenergic I

Question 0

The effect of alpha 2 adrenergic receptors on blood vessels is:

Answer 0

Constrict

Question 1

The effect of alpha 1 adrenergic receptors on blood vessels, uterus, and bronchi is:

Answer 1

Constriction/contraction

Question 2

The effect of beta 1 adrenergic receptor activation is:

Answer 2

Increase HR,Contractility, and conduction velocity

Question 3

the effect of Beta 2 adrenergic receptors on blood vessels and the uterus is:

Answer 3

Dilation/relaxation

Question 4

Phenylephrine
Brand name:
Class:
Action:
Indications (3):

Answer 4

Brand name: Neosynephrine
Class: Alpha adrenergic receptor agonist (mostly a1, some a2)
Actions: Vaso/Venoconstriction by contracting smooth muscle.
Indications:
1. Nasal Decongestant
2. Mydriatic (dilates pupils for eye exam)
3. Increase BP in vasodilated state

Question 5

Isoproterenol
Brand name:
Class:
Actions:
May cause:

Answer 5

Brand: Isuprel
Class: Synthetic B1 and B2 adrenergic receptor agonist
Action/indication: Potent B1/B2 stimulation -> Increase contractility, Increase HR, increase conduction. Will also cause vasodilation!

May cause tachyarrhythmias

Question 6

Albuterol
Brand name:
Class:
Action: 
Indications (2):
Side effects:

Answer 6

Brand: Ventolin
Class: Synthetic selective B2 receptor agonist (little B1 stimulation at low doses)
Actions: Potent B2 agonist for smooth muscle in airways
Indications: asthma, COPD,

Question 7

Mirabegron
Brand:
Actions:
Indications:

Answer 7

Brand name Myrbetriq
Class: Synthetic selecctive B3 adrenergic receptor agonist
Action: Stimulate B3 receptors of smooth muscle of bladder, reducing DETRUSOR muscle tone
Indications: Overactive bladder, urinary urgency, increases bladder capacity, does not have sx associated with anticholinergics.

Question 8

Epinephrine
Class:
PD:
PK:
Tox:
Interactions:
consider:
indication/dose:
monitor:

Answer 8

Class: direct acting adrenergic agonist (a1 a2 B1 B2), vassopressor, cardiac stimulant, bronchodilator, tx for anaphylaxis, adjunct to local anesthesia.

PD: Major action = stimulate peripheral a1 adrenoreceptors producing vaso and venoconstriction; stimulates B1 -> tachycardia + contractility; stimulates B2 -> bronchodilation.

PK: IV is immediate, IM varies, SC 5-15 min, inhale 1-5 min. Opthalmic topical; metabolized by COMT and RENAL EXCRETION.

Tox: excessive vasocontriction, HTN, Hemoraggic stroke, angina, arrythmias.

Interactions: risk of HTN in pts on PROPRANALOL

Considerations: Used severe anaphylaxis.

Dose: 0.1-0.5 mg SC or IM; for cardiac arrest push 1-5 mg IV. for infusion 1-4mcg/min.

Monitor: BP HR rythm, infusion site, extravasation

Question 9

What 2 compounds metabolize Norepinephrine?

Answer 9

MAO and COMT
monoamine oxidase
Catecholamine o-methyltransferase

Question 10

Dopamine
Brand:
Class:
Action:
Indications:

Answer 10

Brand name: Intropin
Class: agonist at DA, B1, a1 receptors
Action: is a DA agonist at low doses, a B1 agonist at medium doses, and a1 agonist at high doses.
Indications: SHOCK in ICU; can produce increased contractility (B1) vasoconstriction (a1) and improved mesenteric/renal erfusion (DA).

Question 11

Ephedrine:
Action:
Indication:

Answer 11

Action - indirectly acts to release NE from adrenergic nerve endings. Has some direcct agonism at receptors.

Inidcations: Used in OR to fix mild hypotension; nasal congestion