Adrenoreceptor Blockers

Question 1

Class: non-selective alpha-blocker

MOA: irreversibly blocks alpha adrenergic receptors (a1 > a2)

Uses: pheochromocytoma (pre-surgical)

SE: orthostatic hypotension, reflex tachycardia, GI irritation, myocardial ischemia, vasodilation; LONG EFFECT (covalently binds with alpha receptor)

Answer 1

PHENOXYBENZAMINE

Question 2

Class: non-selective alpha-blocker

MOA: irreversibly blocks alpha adrenergic receptors (a1 > a2)

Uses: pheochromocytoma (pre-surgical), ANTIDOTE TO ALPHA-1 AGONIST OVERDOSE, rebound hypertension

SE: orthostatic hypotension, reflex tachycardia, GI irritation, vasodilation

Answer 2

PHENTOLAMINE, TOLAZOLINE

Question 3

Class: alpha-1-blocker

MOA: selectively blocks alpha-1 adrenergic receptors

Uses: BPH, HTN

SE: first dose orthostatic hypotension, reflex tachycardia (less common/severe)

Similar:
DOXAZOSIN
TERAZOSIN
TAMSULOSIN - most selective for prostatic smooth muscle
SILODOSIN
ALFUZOSIN

Answer 3

PRAZOSIN

Question 4

Class: non-selective beta-blocker

MOA: blocks beta adrenergic receptors, blocks sympathetic effects on heart and BP, reduces renin release

Uses: angina prophylaxis, HTN, arrhythmias, migraine, performance anxiety, hyperthyroidism

SE: bronchospasm, AV block, HF, CNS sedation, erectile dysfunction; masks symptoms of hypoglycemia in diabetics

Similar:
PINDOLOL - intrinsic sympathomimetic activity; partial agonist (less bronchospasm, may be used in asthmatics)
TIMOLOL - absent local anesthetic activity; safe for use in eye (glaucoma)
LABETALOL - combined alpha- and beta-blocker (used for pheochromocytoma)
CARVEDILOL - combined alpha- and beta-blocker (used for pheochromocytoma)
NADOLOL
LEVOBUNOLOL
METIPRANOLOL

Answer 4

PROPRANOLOL

Question 5

Class: beta-1-blocker

MOA: blocks beta-1 adrenergic receptors, blocks sympathetic effects on heart and BP

Uses: angina, HTN, HF

SE: bronchospasm (less), AV block, HF, CNS sedation, erectile dysfunction

Similar:
BETAXOLOL - absent local anesthetic activity; safe for use in eye (glaucoma)
ESMOLOL - for SVT (shortest half-life)
ACEBUTOLOL - intrinsic sympathomimetic activity; partial agonist (less bronchospasm, may be used in asthmatics)
METOPROLOL
ALPRENOLOL
NEBIVOLOL

Answer 5

ATENOLOL